Successful Use of Cidofovir in an Immunocompetent Child With Severe Adenoviral Sepsis

Alcamo, Alicia M.; Wolf, Michael S.; Alessi, Lauren; Chong, Hey; Green, Michael; Williams, John V.; Simon, Dennis

doi:10.1542/peds.2019-1632

Cited by 26 publications

(18 citation statements)

References 44 publications

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“…There is the lack of current guidance for indication, dosing and duration of antiviral agents used in patients with adenovirus requiring ECMO support. Nevertheless, the previous patient cases shown in Table 2 and our case series demonstrate that cidofovir may be utilized in patients supported by ECMO 12‐17 . The unique pharmacokinetic properties of cidofovir, such as its low volume of distribution, low protein binding and low lipophilicity, prevent cidofovir from being sequestered by the ECMO circuit 3,7‐10 .…”

Section: What Is New and Conclusionmentioning

confidence: 70%

Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus‐associated acute respiratory distress syndrome in paediatric patients— a case series

Brown

Namtu

et al. 2020

J Clin Pharm Ther

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What is known and objective Reports of cidofovir dosing with extracorporeal membrane oxygenation (ECMO) support are limited. This case series describes our clinical experience and provides a literature review regarding cidofovir dosing in paediatric patients requiring ECMO support. Case summary Three patients with adenovirus‐associated acute respiratory distress syndrome (ARDS) were treated with cidofovir while requiring ECMO support. A 27‐month‐old patient was treated with cidofovir 1 mg/kg/dose three times weekly, and a 19‐month‐old patient and an 18‐year‐old patient were treated with cidofovir 5 mg/kg/dose weekly. What is new and conclusion This case series describes the dosing and positive clinical response of cidofovir in paediatric patients with adenovirus‐associated ARDS requiring ECMO support.

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Section: What Is New and Conclusionmentioning

confidence: 70%

Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus‐associated acute respiratory distress syndrome in paediatric patients— a case series

Brown

Namtu

et al. 2020

J Clin Pharm Ther

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“…In conventional medicine, interaction between pharmaceuticals is occasionally used for benefit. Examples include the use of ritonavir to “boost” other protease inhibitors via CYP 3A4 inhibition [ 49 ] and the use of probenecid to prevent cidofovir-related renal toxicity through inhibition of renal anion transporters [ 50 ]. That piperine in black pepper inhibits the p-glycoprotein transporter should not automatically be judged in a negative light; it may enhance bioavailability/effectiveness of chemotherapeutic agents and other botanical constituents via inhibition of p-glycoprotein [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Herb–Drug Interactions: Worlds Intersect with the Patient at the Center

Babos

Heinan²,

Redmond

et al. 2021

Medicines

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This review examines three bodies of literature related to herb–drug interactions: case reports, clinical studies, evaluations found in six drug interaction checking resources. The aim of the study is to examine the congruity of resources and to assess the degree to which case reports signal for further study. A qualitative review of case reports seeks to determine needs and perspectives of case report authors. Methods: Systematic search of Medline identified clinical studies and case reports of interacting herb–drug combinations. Interacting herb–drug pairs were searched in six drug interaction resources. Case reports were analyzed qualitatively for completeness and to identify underlying themes. Results: Ninety-nine case-report documents detailed 107 cases. Sixty-five clinical studies evaluated 93 mechanisms of interaction relevant to herbs reported in case studies, involving 30 different herbal products; 52.7% of these investigations offered evidence supporting reported reactions. Cohen’s kappa found no agreement between any interaction checker and case report corpus. Case reports often lacked full information. Need for further information, attitudes about herbs and herb use, and strategies to reduce risk from interaction were three primary themes in the case report corpus. Conclusions: Reliable herb–drug information is needed, including open and respectful discussion with patients.

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“…Cidofovir (CDV) is a nucleotide analog with broad antiviral activity against DNA viruses including AdVs [ 168 , 169 , 170 ]. Some case reports have demonstrated success in using CDV to treat disseminated AdV in immunocompromised patients, including hematopoietic stem cell transplant patients [ 171 ] and treatment of extra-gastrointestinal infection in immunocompetent patients [ 172 ], making CDV the drug of choice for severe AdV infections [ 173 , 174 ]. Due to low bioavailability of CDV and its nephrotoxicity, attempts to develop derivatives with better pharmacokinetics profiles were done.…”

Section: Antiviral Targets and Known Antiviralsmentioning

confidence: 99%

Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections

et al. 2021

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Acute gastroenteritis caused by virus has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The main culprits are rotaviruses, noroviruses, sapoviruses, astroviruses, and enteric adenoviruses. Currently, there are no antiviral drugs available for the prevention or treatment of viral gastroenteritis. Here, we describe the antivirals that were identified as having in vitro and/or in vivo activity against these viruses, originating from in silico design or library screening, natural sources or being repurposed drugs. We also highlight recent advances in model systems available for this (hard to cultivate) group of viruses, such as organoid technologies, and that will facilitate antiviral studies as well as fill some of current knowledge gaps that hamper the development of highly efficient therapies against gastroenteric viruses.

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Successful Use of Cidofovir in an Immunocompetent Child With Severe Adenoviral Sepsis

Cited by 26 publications

References 44 publications

Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus‐associated acute respiratory distress syndrome in paediatric patients— a case series

Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus‐associated acute respiratory distress syndrome in paediatric patients— a case series

Herb–Drug Interactions: Worlds Intersect with the Patient at the Center

Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections

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