Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections

Santos-Ferreira, Nânci; Dycke, Jana Van; Neyts, Johan; Rocha‐Pereira, Joana

doi:10.3390/microorganisms9081599

Cited by 14 publications

(12 citation statements)

References 184 publications

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“…The inclusion of post-exposure antiviral treatment against norovirus infections effectively protects against diarrhea and reduces viral excretion in the feces in mouse mortality mode [ 90 ]. Notably, 2CMC has been tested in every available model and considered a reference compound for NoV [ 91 ]. Ribavirin is an analogue of guanosine and the first drug that inhibits MNV and HuNoV replication [ 92 ].…”

Section: Resultsmentioning

confidence: 99%

A Bibliometric Analysis of the Literature on Norovirus Disease from 1991–2021

Ogunsakin

Ebenezer

Ginindza

2022

IJERPH

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Norovirus (NoV) is one of the oldest recognized diseases and the leading causal pathogen for acute gastroenteritis (AGE) worldwide. Though numerous studies have been reported on NoV disease, limited research has explored the publication trends in this area. As a result, the objective of this work was to fill the void by conducting a bibliometric study in publication trends on NoV studies as well as discovering the hotspots. The Web of Science central assemblage database was hunted for publications from 1991 to 2021 with “norovirus” in the heading. Microsoft Excel 2016, VOSviewer, R Bibliometrix, and Biblioshiny packages were deployed for the statistical analysis of published research articles. A total of 6021 published documents were identified in the Web of Science database for this thirty-year study period (1991–2021). The analyses disclosed that the Journal of Medical Virology was the leading journal in publications on norovirus studies with a total of 215 published articles, the Journal of Virology was the most cited document with 11,185 total citations. The United States of America (USA) has the most significant productivity in norovirus publications and is the leading country with the highest international collaboration. Analysis of top germane authors discovered that X. Jiang (135) and J. Vinje (119) were the two top relevant authors of norovirus publications. The commonly recognized funders were US and EU-based, with the US emerging as a top funder. This study reveals trends in scientific findings and academic collaborations and serves as a leading-edge model to reveal trends in global research in the field of norovirus research. This study points out the progress status and trends on NoV research. It can help researchers in the medical profession obtain a comprehensive understanding of the state of the art of NoV. It also has reference values for the research and application of the NoV visualization methods. Further, the research map on AGE obtained by our analysis is expected to help researchers efficiently and effectively explore the NoV field.

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Section: Resultsmentioning

confidence: 99%

A Bibliometric Analysis of the Literature on Norovirus Disease from 1991–2021

Ogunsakin

Ebenezer

Ginindza

2022

IJERPH

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“…These compounds are still in pre-clinical stages. For a comprehensive review in this topic, read [131].…”

Section: Antivirals: Not There Yetmentioning

confidence: 99%

Norovirus: Facts and Reflections from Past, Present, and Future

Lucero

Matson²,

Ashkenazi

et al. 2021

Viruses

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Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the “Norwalk virus” by Kapikian and colleagues, the scientific and medical community continue to generate new knowledge on the full biological and disease spectrum of Norovirus infection. Nevertheless, several areas remain incompletely understood due to the serious constraints to effectively replicate and propagate the virus. Here, we present a narrated historic perspective and summarize our current knowledge, including insights and reflections on current points of interest for a broad medical community, including clinical and molecular epidemiology, viral–host–microbiota interactions, antivirals, and vaccine prototypes. We also include a reflection on the present and future impacts of the COVID-19 pandemic on Norovirus infection and disease.

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“…Intravenous cytosine nucleotide analogue (CDV) that inhibits DNA polymerase has the highest in vitro activity against adenovirus, and is the preferred therapeutic agent. Elevation in lymphocyte counts (specifically CD4) were correlated with the clearance of AdV infection and improvement in survival [ 56 , 57 ].…”

Section: Causative Agents Of Agementioning

confidence: 99%

Acute Infectious Gastroenteritis: The Causative Agents, Omics-Based Detection of Antigens and Novel Biomarkers

et al. 2021

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Acute infectious gastroenteritis (AGE) is among the leading causes of mortality in children less than 5 years of age worldwide. There are many causative agents that lead to this infection, with rotavirus being the commonest pathogen in the past decade. However, this trend is now being progressively replaced by another agent, which is the norovirus. Apart from the viruses, bacteria such as Salmonella and Escherichia coli and parasites such as Entamoeba histolytica also contribute to AGE. These agents can be recognised by their respective biological markers, which are mainly the specific antigens or genes to determine the causative pathogen. In conjunction to that, omics technologies are currently providing crucial insights into the diagnosis of acute infectious gastroenteritis at the molecular level. Recent advancement in omics technologies could be an important tool to further elucidate the potential causative agents for AGE. This review will explore the current available biomarkers and antigens available for the diagnosis and management of the different causative agents of AGE. Despite the high-priced multi-omics approaches, the idea for utilization of these technologies is to allow more robust discovery of novel antigens and biomarkers related to management AGE, which eventually can be developed using easier and cheaper detection methods for future clinical setting. Thus, prediction of prognosis, virulence and drug susceptibility for active infections can be obtained. Case management, risk prediction for hospital-acquired infections, outbreak detection, and antimicrobial accountability are aimed for further improvement by integrating these capabilities into a new clinical workflow.

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Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections

Cited by 14 publications

References 184 publications

A Bibliometric Analysis of the Literature on Norovirus Disease from 1991–2021

A Bibliometric Analysis of the Literature on Norovirus Disease from 1991–2021

Norovirus: Facts and Reflections from Past, Present, and Future

Acute Infectious Gastroenteritis: The Causative Agents, Omics-Based Detection of Antigens and Novel Biomarkers

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