Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus‐associated acute respiratory distress syndrome in paediatric patients— a case series

Le, Thao; Brown, Brian K.; Namtu, Katie; Berman, David M.; Kiskaddon, Amy

doi:10.1111/jcpt.13244

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…Cidofovir (CDV) is a cytosine nucleotide analog that inhibits DNA polymerase; it has the highest in vitro activity against HAdV among the currently available antiviral agents and it is the currently preferred therapeutic agent [ 131 , 142 , 143 , 144 ], though it is only available intravenously [ 144 ]. Regimens (dose, frequency and period) are variable.…”

Section: Treatmentmentioning

confidence: 99%

“…Its use is recommended in immunosuppressed patients with solid organ transplantation and hematopoietic stem cell transplantation, who have been infected with HAdV. In immunocompetent patients who require critical care units, particularly mechanical ventilation and extracorporeal membrane oxygenation (ECMO) could be used [ 131 , 143 , 144 ].…”

Section: Treatmentmentioning

confidence: 99%

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An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat?

Saint-Pierre

Conei

Lizama

et al. 2023

Viruses

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Human adenoviruses (HAdV) are one of the most important pathogens detected in acute respiratory diseases in pediatrics and immunocompromised patients. In 1953, Wallace Rowe described it for the first time in oropharyngeal lymphatic tissue. To date, more than 110 types of HAdV have been described, with different cellular tropisms. They can cause respiratory and gastrointestinal symptoms, even urinary tract inflammation, although most infections are asymptomatic. However, there is a population at risk that can develop serious and even lethal conditions. These viruses have a double-stranded DNA genome, 25–48 kbp, 90 nm in diameter, without a mantle, are stable in the environment, and resistant to fat-soluble detergents. Currently the diagnosis is made with lateral flow immunochromatography or molecular biology through a polymerase chain reaction. This review aimed to highlight the HAdV variability and the pandemic potential that a HAdV3 and 7 recombinant could have considering the aggressive outbreaks produced in health facilities. Herein, we described the characteristics of HAdV, from the infection to treatment, vaccine development, and the evaluation of the social determinants of health associated with HAdV, suggesting the necessary measures for future sanitary control to prevent disasters such as the SARS-CoV-2 pandemic, with an emphasis on the use of recombinant AdV vaccines to control other potential pandemics.

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Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat?

Saint-Pierre

Conei

Lizama

et al. 2023

Viruses

View full text Add to dashboard Cite

show abstract

“…Cidofovir, a viral DNA polymerase inhibitor, is used to treat adenovirus infections in certain patients. 92,93 However, it is not recommended as treatment in immunocompetent patients due to its limited antiviral activity and nephrotoxicity. 84,94 Patients with RSV pneumonia and influenza B virus pneumonia have similar epidemiology, clinical characteristics, and severity.…”

Section: Severe Lvri Due To Non-influenza Virusesmentioning

confidence: 99%

Severe Infections Due to Respiratory Viruses

Cillóniz

Pericàs

Rojas

2022

Semin Respir Crit Care Med

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Severe viral infections may result in severe illnesses capable of causing acute respiratory failure that could progress rapidly to acute respiratory distress syndrome (ARDS), related to worse outcomes, especially in individuals with a higher risk of infection, including the elderly and those with comorbidities such as asthma, diabetes mellitus and chronic respiratory or cardiovascular disease. In addition, in cases of severe viral pneumonia, co-infection with bacteria such as Streptococcus pneumoniae and Staphylococcus aureus is related to worse outcomes. Respiratory viruses like influenza, rhinovirus, parainfluenza, adenovirus, metapneumovirus, respiratory syncytial virus, and coronavirus have increasingly been detected. This trend has become more prevalent, especially in critically ill patients, due to the availability and implementation of molecular assays in clinical practice. Respiratory viruses have been diagnosed as a frequent cause of severe pneumonia, including cases of community-acquired pneumonia, hospital-acquired pneumonia, and ventilator-associated pneumonia. In this review, we will discuss the epidemiology, diagnosis, clinical characteristics, management, and prognosis of patients with severe infections due to respiratory viruses, with a focus on influenza viruses, non-influenza viruses, and coronaviruses.

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“…Its use is recommended in immunosuppressed patients with solid organ transplantation and hematopoietic stem cell transplantation, who have infected with HAdV. In immunocompetent patients who require critical care units, particularly mechanical ventilation and extracorporeal membrane oxygenation (ECMO) could be used (134,147,148,149).…”

Section: Treatmentmentioning

confidence: 99%

An Old Acquaintance. Could Adenovirus be our Next Pandemic Threat?

Saint-Pierre¹,

Conei²,

Lizama³

et al. 2022

Preprint

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Human adenoviruses are one of the most important pathogens detected in acute respiratory diseases in pediatrics and immunocompromised patients. In 1953, Wallace Rowe described it for the first time in oropharyngeal lymphatic tissue. To date, more than 85 types of HAdV have been described, with different cellular tropisms. They can cause respiratory and gastrointestinal symptoms, even urinary tract inflammation, although most infections are asymptomatic. However, there is a population at risk that can develop serious and even lethal conditions. These viruses have a double-stranded DNA genome, 25-48 kbp, 90 nm in diameter, without a mantle, stable in the environment, and resistant to fat-soluble detergents. Currently the diagnosis is made with lateral flow immunochromatography or molecular biology through a polymerase chain reaction. The objective of this review is to recognize the variability of HAdV, the pandemic potential that a recombinant could present between HAdV-3 and 7 viral types, known to produce aggressive outbreaks in health facilities. The review determined the characteristics of HAdV, from the infection to treatment, vaccine development and the evaluation of the social determinants of health associated with HAdV, guiding the necessary measures for future sanitary control, and preventing disasters such as the SARS-CoV-2 pandemic.

show abstract

Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus‐associated acute respiratory distress syndrome in paediatric patients— a case series

Cited by 4 publications

References 16 publications

An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat?

An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat?

Severe Infections Due to Respiratory Viruses

An Old Acquaintance. Could Adenovirus be our Next Pandemic Threat?

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