Successful treatment with multiple intra‐articular injections of infliximab in a patient with psoriatic arthritis

Abstract

This case report presents the clinical and radiographic course of temporomandibular joint (TMJ) involvement in a patient with severe TMJ symptoms from psoriatic arthritis (PsA) resistant to both systemic infliximab and intra-articular glucocorticoid and who therefore received multiple intra-articular infliximab injections for 36 weeks. TMJ symptoms improved after the first bilateral intra-articular infliximab injections but even more so after the second injections. The considerable improvement remained for the 36 weeks studied. Bilateral computerized tomography showed no progression in radiographic changes during the treatment. No adverse reaction was observed from the intra-articular injections.

Juvenile Idiopathic Arthritis Overview and Involvement of the Temporomandibular Joint

“…Similar to juvenile arthritis, various forms of adult arthritis, such as adult RA, osteoarthritis, psoriatic arthritis, and ankylosing spondylitis, also may have TMJ involvement. [44][45][46] The significant changes that occur in the TMJ during the pediatric years and the lack of randomized, double-blind, placebocontrolled trials for TMJ arthritis point to the need for early recognition, thorough evaluation by the oral and maxillofacial surgeon and rheumatologist for etiology, then determination of optimal therapeutic options, such as physical therapy, splints, medications, or surgical intervention. In the past decade, there have been significant advances in the care of patients with inflammatory arthritis.…”

Role of scintigraphy with 99mTc-infliximab in predicting the response of intraarticular infliximab treatment in patients with refractory monoarthritis

“…In the last few years, some experience with intraarticular (IA) treatment with TNF antagonists in patients with refractory monoarthritis has been reported. The majority of these patients have been treated with infliximab, and only a few studies have evaluated the efficacy of etanercept and adalimumab IA treatment [4][5][6][7][8][9][10][11][12][13][14][15].…”

Establishment of temporomandibular joint puncture technique in rats usingin vivomicro-computed tomography (R_mCT®)

“…[8][9][10] Many cytokines are involved in TMJ disorders, 11 and a variety of anti-arthritic drugs will be developed in the future. In the field of drug discovery, animal experiments are performed to develop therapeutic agents and evaluate efficacy.…”