Successful Treatment of Vitiligo With Puva‐pigmented Autologous Epidermal Grafting

Suga, Yasushi; Butt, Khalid Iqbal; Takimoto, Reiko; Fujioka, Noriko; Yamada, Hiromichi; Ogawa, Hideoki

doi:10.1111/j.1365-4362.1996.tb01673.x

Cited by 44 publications

(42 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In case of the full-thickness grafts, punch biopsies are taken at a distance of 1–5 mm from each other under local anaesthesia [1, 14]. For the blister technique, bullae can be induced manually with liquid nitrogen (3–6 freeze-thaw cycles for 3–5 s [13]) or with appropriately sized cups of sterilized disposable syringes at a sustained suction pressure of approximately 300 mm Hg for 30 min to 3 h [15]. The bullae can also be harvested using a specifically designed machine to generate suction blisters.…”

Section: Procedures For Harvesting Donor Skinmentioning

confidence: 99%

Surgical Techniques for Vitiligo: A Review

Geel

Ongenae

Naeyaert³

2001

Dermatology

View full text Add to dashboard Cite

Although the treatment of vitiligo has improved during the last decade, therapy is still not satisfying for many patients. This is probably due to the fact that the aetiopathogenesis is unknown. Several treatment modalities, such as PUVA, UVB and local corticosteroids are currently used in the treatment of active vitiligo. However, these treatments usually induce incomplete repigmentation. Surgical methods intended to repigment leucoderma are an interesting therapeutic option if patients have stable disease. Two types of surgical techniques are available: tissue grafts and cellular grafts, with in between autologous cultured epithelial grafts. Tissue grafts are full-thickness punch grafts, split-thickness grafts and suction blister grafts. With tissue grafts, only a limited surface area can be treated but with good results in the majority of cases. Cellular grafts include non-cultured keratinocytes/melanocytes and cultured melanocytes. The exact success rate of repigmentation with cellular grafts is still unknown, since only a small number of studies have been published. Starting from autologous cellular suspensions, epithelial grafts of various compositions can be cultured in vitro. They can be used for larger areas. The purpose of this review is to describe the applications of different surgical techniques used to treat recalcitrant vitiligo.

show abstract

Section: Procedures For Harvesting Donor Skinmentioning

confidence: 99%

Surgical Techniques for Vitiligo: A Review

Geel

Ongenae

Naeyaert³

2001

Dermatology

View full text Add to dashboard Cite

show abstract

“…(29)(30)(31) The repigmentation rate in these studies according to the review by Njoo et al was 87%, whereas Ozdemi et al reported rates between 25% -65%. (29)(30)(31)(32)(33)(34)(35)(36) In the study by Maleki et al, ten patients with refractory vitiligo who were treated by suction blister graft and subsequent PUVA therapy reported over 90% repigmentation in seven patients. In studies of blister grafting followed without phototherapy, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…(39) Scar formation, keloid, cobblestoning, sinking pits, thick margins and milia formation was much less compared to split thickness grafting or punch grafting. (33) …”

Section: Advantagesmentioning

confidence: 99%

Suction Blister Grafting- Still a Useful Modality for Treatment of Resistant and Stable Vitiligo

S¹,

Chittoory²

2017

jemds

View full text Add to dashboard Cite

BACKGROUNDVitiligo is a common depigmentation disorder due to absence of functional melanocytes in the affected area. Depending on the type, extent and duration of vitiligo, conventional medical therapies and phototherapy are used. Medical treatment is effective in only 60% -70% of the patients. This has led to the evolution of various surgical modalities to treat recalcitrant stable lesions. The aim of this study was to determine the efficacy of suction blister grafts for treatment of recalcitrant and stable vitiligo. MATERIALS AND METHODSThis study was conducted on 20 patients with stable vitiligo. They included lip vitiligo (6 cases), segmental vitiligo (6 cases) and focal vitiligo (8) that were resistant to conventional medical treatments. Manual suction with 20 cc disposable syringes for blisters at donor site and dermabrasion at recipient site was done. The blister was separated, fixed at recipient site and dressing was done followed by NBUVB thrice a week for 3 months. Repigmentation of lesions was evaluated monthly for 6 months after treatment. Repigmentation rates > 90%, 71% -90%, 51% -70% and < 50% were graded as complete, good, moderate and poor respectively. RESULTSThis study includes 20 patients (10 female and 10 male) with stable vitiligo were evaluated for response following suction blister grafting with thrice weekly post-graft phototherapy. Reponses to treatment after a 6-month followup were 'complete,' 'good' and 'moderate' in 12 (60%), 6 (30%) and 2 (10%) patients respectively and one patient was lost for followup. CONCLUSIONThe grafting procedures in vitiligo are performed for cosmetic purposes. Proper selection of the patient is the most important factor for achieving a good cosmetic result. Stability of the disease process is the most important parameter to achieve a successful outcome. Suction blister grafting gives excellent cosmetic results with minimal chances of scarring at the donor or recipient sites.

show abstract

“…Unfortunately failures are still anticipated in many cases. For better results, phototherapy or photochemotherapy of donor and recipient sites can also be performed before and after grafting [11,14,27]. The purpose of this work is to evaluate how effective suction blister grafts with concomitant phototherapy are in treatment of resistant vitiligo cases that had failed to respond to classic phototherapy.…”

Section: Introductionmentioning

confidence: 99%

“…Because of these disappointing outcomes, several surgical methods were introduced in the hope of achieving a more encouraging response. Surgical techniques are reserved for patients with stable vitiligo that is unresponsive to conventional therapies [11][12][13][14]. A number of dermatosurgery techniques are available to promote repigmentation of vitiligo: mini-or punch grafts, split-thickness skin grafts, cultured epidermal sheets, cultured melanocyte suspensions, follicular grafts and suction blister epidermal grafts [15][16][17][18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of suction blister epidermal grafting with concomitant phototherapy in vitiligo treatment

Iwanowski

Szlązak

Rustowska

et al. 2018

pdia

View full text Add to dashboard Cite

A b s t r a c tIntroduction: There are many surgical methods for vitiligo treatment that have been used for over 30 years. Suction blister epidermal grafting (SBEG) is considered one of the simplest and most effective of them. Aim: To determine how effective suction blister grafts with concomitant phototherapy are in vitiligo treatment. Material and methods: The study was conducted on 10 patients with vitiligo that was resistant to previous treatment including phototherapy in monotherapy. Involvement of affected sites was different for every patient. We used cryotherapy for blistering at the recipient site and an automatic suction device for blistering at the donor site. The blister was separated from the donor site and fixed with dressing to the recipient site. After removing the final dressing (about 7 days after SBEG) patients started phototherapy (6 patients had UVB 311 nm and 4 had PUVA). All patients treated with UVB 311 nm were qualified for treatment in our clinic and the method was chosen according to expert recommendations from the European Dermatology Forum (EDF) Guidelines for Vitiligo where narrowband (NB) UVB is the phototherapy of choice. Three patients who had PUVA therapy were treated with this method in other clinical centers and sent to us only to undergo SBEG. One patient had previously received UVB 311 nm for 3 months, which showed no effects. Repigmentation of lesions was evaluated at 3 and 6 months after the surgical procedure. Results: Ten patients (9 females with a mean age of 36.88 years and 1 man aged 39 years) were enrolled in the study. Nine patients showed progressive repigmentation at 3 and 6 months follow-up with a rate varying from 13 to 76% (mean: 44.5%) and 35 to 100% (mean: 67.5%). One patient showed 5% depigmentation at a visit after 6 months in comparison to the follow-up visit 3 months after SBEG. Conclusions: With this technique, patients who did not respond to the usual treatments showed very good repigmentation over a 6-month follow-up. There were no side effects such as scarring.

show abstract

Successful Treatment of Vitiligo With Puva‐pigmented Autologous Epidermal Grafting

Abstract: This novel procedure is an excellent tool by which to treat segmental and localized vitiligo lesions that have failed to respond to other therapies.

Cited by 44 publications

References 25 publications

Surgical Techniques for Vitiligo: A Review

Surgical Techniques for Vitiligo: A Review

Suction Blister Grafting- Still a Useful Modality for Treatment of Resistant and Stable Vitiligo

Efficacy of suction blister epidermal grafting with concomitant phototherapy in vitiligo treatment

Contact Info

Product

Resources

About