2017
DOI: 10.14260/jemds/2017/1229
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Suction Blister Grafting- Still a Useful Modality for Treatment of Resistant and Stable Vitiligo

Abstract: BACKGROUNDVitiligo is a common depigmentation disorder due to absence of functional melanocytes in the affected area. Depending on the type, extent and duration of vitiligo, conventional medical therapies and phototherapy are used. Medical treatment is effective in only 60% -70% of the patients. This has led to the evolution of various surgical modalities to treat recalcitrant stable lesions. The aim of this study was to determine the efficacy of suction blister grafts for treatment of recalcitrant and stable … Show more

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“…We analyzed a total of 117 unique studies with 8776 unique patients (eTable 1 in the Supplement), including 19 studies with 1631 patients in the punch grafting group, 10 studies with 718 patients in the thin skin grafting group, 29 studies with 2652 patients in the suction blister grafting group, 45 studies with 2209 patients in the noncultured epidermal cell suspension (NCES) group, 9 studies with 185 patients in the noncultured follicular cell suspension (NCFS) group, and 17 studies with 1381 patients in the cultured epidermal cell suspension (CES) group; 11 studies included more than 1 procedure type. The median follow-up duration was 7 (range, 2-108) months.…”
Section: Resultsmentioning
confidence: 99%
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“…We analyzed a total of 117 unique studies with 8776 unique patients (eTable 1 in the Supplement), including 19 studies with 1631 patients in the punch grafting group, 10 studies with 718 patients in the thin skin grafting group, 29 studies with 2652 patients in the suction blister grafting group, 45 studies with 2209 patients in the noncultured epidermal cell suspension (NCES) group, 9 studies with 185 patients in the noncultured follicular cell suspension (NCFS) group, and 17 studies with 1381 patients in the cultured epidermal cell suspension (CES) group; 11 studies included more than 1 procedure type. The median follow-up duration was 7 (range, 2-108) months.…”
Section: Resultsmentioning
confidence: 99%
“…Overall, the rate of repigmentation achieved by patients after 1 session of any surgical intervention included greater than 90% in 52.69% (95% CI, 46.87%-58.50%) in 106 studies with 6586 patients ( I 2 = 97.2%) (eFigure 2 in the Supplement); greater than 75% in 64.72% (95% CI, 59.52%-69.92%) in 100 studies with 3400 patients ( I 2 = 95.7%); and greater than 50% in 81.01% (95% CI, 78.18%-83.84%) in 92 studies with 5462 patients ( I 2 = 90.7%). According to the surgical intervention type, greater than 90% repigmentation was achieved in 72.08% (95% CI, 54.26%-89.89%) of patients undergoing thin skin grafting (670 patients in 8 studies), 61.68% (95% CI, 47.44%-75.92%) of patients undergoing suction blister grafting (2349 patients in 21 studies), 56.82% (95% CI, 48.93%-64.71%) of patients undergoing CES (1138 patients in 14 studies), 47.51% (95% CI, 37.00%-58.03%) of patients undergoing NCES (907 patients in 29 studies), 45.76% (95% CI, 30.67%-60.85%) of patients undergoing punch grafting (1354 patients in 11 studies), and 36.24% (95% CI, 18.92%-53.57%) of patients undergoing NCFS (160 patients in 8 studies) after 1 session of each surgery (eFigure 2 in the Supplement and Table 1). In our meta-regression analysis, for greater than 90% repigmentation, the estimate of the slopes for mean age of patients was −1.1418 ( P = .02); for the proportion of segmental vitiligo, 0.3047 ( P = .01); and for the proportion of treated lesions on the acral and joint areas, −0.4050 ( P = .002) (Figure 2).…”
Section: Resultsmentioning
confidence: 99%