Successful Treatment of Vitiligo by Needling with Topical 5 Fluorouracil

Vedamurthy, Maya; Moorthy, Aarthi; Samuel, Soumya

doi:10.4172/2376-0427.1000242

Cited by 10 publications

(11 citation statements)

References 14 publications

(14 reference statements)

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“…Vedamurthy et al conducted a trial on 3 cases of vitiligo using needling and 5‐FU, and the cases showed >75% repigmentation, but we cannot compare with his study as it included only 3 cases.…”

Section: Discussionmentioning

confidence: 91%

Evaluation of the additional effect of topical 5‐fluorouracil to needling in the treatment of localized vitiligo

Attwa

Khashaba

Ezzat

2019

J of Cosmetic Dermatology

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Background:Microneedling is a valuable tool that can be used in transdermal drug delivery in vitiligo patients to improve drug permeability and efficacy with minor side effects. Aims:The aim of this study is to assess the effectiveness of using microneedling prior to application of topical 5-FU in treatment of localized vitiligo and to compare its results with microneedling alone. Methods:Twenty-seven patients with localized stable vitiligo are chosen. Two patches are determined in every patient: patch A treated with needling alone and patch B treated with needling followed by topical application of 5-fluorouracil once every 2 weeks for three months. Repigmentation was accessed by grades ranging from G0; no response to G4; >75% repigmentation. Side effects were reported in every visit. Results:Microneedling followed by topical application of 5-fluorouracil showed better response than needling alone with minimal side effects. Conclusion:Combining microneedling with topical drug application yields better results in treating localized vitiligo. K E Y W O R D S 5-fluorouracil, needling, vitiligoHow to cite this article: Attwa EM, Khashaba SA, Ezzat NA.Evaluation of the additional effect of topical 5-fluorouracil to needling in the treatment of localized vitiligo. J Cosmet

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Section: Discussionmentioning

confidence: 91%

Evaluation of the additional effect of topical 5‐fluorouracil to needling in the treatment of localized vitiligo

Attwa

Khashaba

Ezzat

2019

J of Cosmetic Dermatology

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“…The efficacy of dermabrasion combined with topical 5‐FU cream reached 56.67% in 4 months and 73.33% in 6‐month follow‐up . In a case report, 75% improvement was reported in three patients after multiple superficial punctures of vitiligo patches combined application of 5‐FU cream . The efficacy of topical 5‐FU combined with micro‐needling was superior to micro‐needling alone in 6 months after therapy (60.34% vs 22.22%, respectively) and another report of more than 75% repigmentation in 49% of the vitiligo patches after topical 5‐FU combined with micro‐needling .…”

Section: Discussionmentioning

confidence: 99%

Intradermal injection of Fluorouracil versus triamcinolone in localized vitiligo treatment

Zohdy

Hussein

2018

J of Cosmetic Dermatology

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Summary Background Vitiligo is an autoimmune disease with a prevalence of 1.22% in Egypt. Intralesional steroids use in localized vitiligo treatment still a matter of debate. Fluorouracil was tried in vitiligo treatment after lesion dermabrasion, ablative laser, or micro‐needling. The study aimed to compare the efficacy of intradermal fluorouracil and triamcinolone acetonide without any adjuvant therapy in localized vitiligo treatment. Patients and methods Sixty patients with localized non‐segmental stable vitiligo were assigned randomly and equally into groups. Patients subjected to intradermal injection of either fluorouracil (50 mg/mL), triamcinolone acetonide (3 mg/mL) or an equal mixture of both drugs. All patients had four treatment sessions every 2 weeks were followed up for 6 months. Results Intradermal fluorouracil showed the best overall improvement (median 52.27, IQR 36.25‐68.18) when compared with triamcinolone (median 13.86, IQR 3.83‐33.32) and the drug mixture (median 17.15, IQR 7.48‐41.67). During follow‐up, the vitiliginous patches continued to repigment for 6 months in fluorouracil and the drug mixture groups. The improvement stopped 1 month after the last session in the triamcinolone group. Conclusion The intradermal fluorouracil injection is an effective treatment of localized vitiligo. The intradermal steroid has a short‐acting therapeutic effect, but the mixture of drugs added no therapeutic effect.

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“…In contrast our studied group A, showed good to excellent response in 66.7% of cases and 33.3% poor response only 3 cases [10%] showed no response. Also, Vedamurthy et al [10] reported on three patients of resistant vitiligo. They were subjected to needling with topical 5% 5-fluorouracil application every two weeks for three months, along with their ongoing therapy.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo

Razek

Obaid

Elshahat

2021

International Journal of Medical Arts

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Background: Latanoprost [LT], a prostaglandin F2-alpha [PGF2α] analogue used in the treatment of glaucoma. It induces skin pigmentation in guinea pigs. The rationale of trying 5-fluorouracil [5-FU] in vitiligo treatment may come from the first report of hyperpigmentation induced by 5-FU as a side effect in the skin tumors and psoriasis treatment The Aim of the work: Comparison between the efficacy of topical latanoprost versus topical 5-fluorouracil after skin dermabrasion in induction of skin repigmentation in stable non-segmental vitiligo. Patients and Methods: This study included thirty Egyptian patients, 18-60 years old, with stable non-segmental vitiligo. They were divided into: group [A] patients subjected to 5 fluorouracil after dermabrasion and group [B] patientssubjected to latanoprost after dermabrasion then followed up every two weeks for three months.Result: There was no statistically significant difference between both groups regarding total response to treatment and degree of repigmentation. However, there was higher response to treatment in group A than group B. In both groups patients were satisfied with the degree of improvement. As regard complication there were minimal complications only one case of koebnerization and two cases of post inflammatory hyperpigmentation Conclusion: 5-fluorouracil 5% was associated with better improvement than latanoprost. However, the difference did not reach statistical significance. Patients reported high satisfaction with the two treatment modalities.

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Successful Treatment of Vitiligo by Needling with Topical 5 Fluorouracil

Cited by 10 publications

References 14 publications

Evaluation of the additional effect of topical 5‐fluorouracil to needling in the treatment of localized vitiligo

Evaluation of the additional effect of topical 5‐fluorouracil to needling in the treatment of localized vitiligo

Intradermal injection of Fluorouracil versus triamcinolone in localized vitiligo treatment

Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo

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