Intradermal injection of Fluorouracil versus triamcinolone in localized vitiligo treatment

Zohdy, Hatem Abo‐El‐Wafa; Hussein, Mohamed Saber

doi:10.1111/jocd.12820

Cited by 11 publications

(13 citation statements)

References 25 publications

(25 reference statements)

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“…26,27 It has a worldwide prevalence of 1%, it occurs mostly before the age of 20 and affects both sexes equally. 4,[28][29][30][31] The loss of melanocytes caused by vitiligo can be treated with microneedling. The latter can potentially stimulate melanocytes and skin pigmentation by creating microinjuries, which leads to the release of growth factors.…”

Section: Discussionmentioning

confidence: 99%

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Microneedling in vitiligo: A systematic review

Salloum

Bazzi

Maalouf

et al. 2020

Dermatologic Therapy

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Microneedling was initially introduced for skin rejuvenation; however, this minimally invasive procedure is now being used for the treatment of multiple dermatological conditions. Recent reports have shown its efficacy in the treatment of vitiligo. This review analyzes the current literature on microneedling techniques, efficacy, and safety for vitiligo treatment. An extensive PubMed was done to identify the literature on microneedling treatment for vitiligo. Case reports, case series, and clinical trials were included in this review. All 14 articles evaluated showed improvement of vitiligo lesions after microneedling treatment. The combination of microneedling and topical tacrolimus, 5-fluorouracil, topical calcipotriol and betamethasone, narrowband ultraviolet B with or without photodynamic therapy, and triamcinolone acetonide solution yielded more efficacy than microneedling monotherapy. Microneedling is a safe and efficient technique in the treatment of vitiligo. Thus, it can be an alternative treatment for vitiligo especially when the latter is resistant to conventional therapies.

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Section: Discussionmentioning

confidence: 99%

“…These patches occur mostly on extremities and are known to be resistant to conventional therapies, hence the importance of finding an effective treatment modality for these difficult‐to‐treat areas 26,27 . It has a worldwide prevalence of 1%, it occurs mostly before the age of 20 and affects both sexes equally 4,28‐31 …”

Section: Discussionmentioning

confidence: 99%

Microneedling in vitiligo: A systematic review

Salloum

Bazzi

Maalouf

et al. 2020

Dermatologic Therapy

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“…Since then, several studies have shown the efficacy of 5-FU in the treatment of vitiligo using different methods of application, such as after skin ablation by laser combined with phototherapy [232], after dermabrasion [233] and by combining it with microneedling [234,235]. A more recent trial demonstrated that in localized NSV, intradermal 5-FU showed better overall improvement compared with intradermal triamcinolone [236]. Its effects were maintained for 6 months, whereas that of triamcinolone stopped at 1 month after the last injection.…”

Section: Alternative Treatment Optionsmentioning

confidence: 99%

Vitiligo: A Review

2020

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Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5-2% of the population worldwide. The disease is characterized by the selective loss of melanocytes which results in typical nonscaly, chalky-white macules. In recent years, considerable progress has been made in our understanding of the pathogenesis of vitiligo which is now clearly classified as an autoimmune disease. Vitiligo is often dismissed as a cosmetic problem, although its effects can be psychologically devastating, often with a considerable burden on daily life. In 2011, an international consensus classified segmental vitiligo separately from all other forms of vitiligo, and the term vitiligo was defined to designate all forms of nonsegmental vitiligo. This review summarizes the current knowledge on vitiligo and attempts to give an overview of the future in vitiligo treatment.

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“…The chosen patches were subjected to intralesional injection of 5-fluorouracil 5% solution (50 mg/mL). At each point, 0.05-0.1 ml was injected with 1 cm apart using insulin syringe [8]. The procedure was repeated every 2 weeks for each patient until improvement reached or for 3 months maximum.…”

Section: Steps Of the Proceduresmentioning

confidence: 99%

Evaluation of Intralesional Injection of 5-fluorouracil in Treatment of Vitiligo

Anber

Ali

El‐Tatawy

et al. 2021

JAMMR

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Background: Vitiligo is a chronic cutaneous disease characterized by depigmented patches that leave psychological impact on the patients. New treatment modalities have been developed to improve the results vitiligo with less side effects. Objective: To evaluate intralesional injection of 5-fluorouracil in treatment of vitiligo. Patients and Methods: The study included 20 localized stable vitiligo patients. Each patient was treated with intralesional injection of 5-fluorouracil every 2 weeks for 3 sessions followed by narrow band sessions twice weekly for 3 months. Results: There was statistically significant repigmentation after treatment with intralesional 5-FU (mean of 50.30 ± 34.60, P value =0.001 Wilcoxon signed ranks test between before and after). 55% of patients showed >50% repigmentation. after 3 months therapy. Side effects were minimal and transient. Conclusion: Intralesional injection of 5-FU is safe and effective in the treatment of vitiligo.

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Intradermal injection of Fluorouracil versus triamcinolone in localized vitiligo treatment

Cited by 11 publications

References 25 publications

Microneedling in vitiligo: A systematic review

Microneedling in vitiligo: A systematic review

Vitiligo: A Review

Evaluation of Intralesional Injection of 5-fluorouracil in Treatment of Vitiligo

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