Successful treatment of pain in two patients with cutaneous leiomyomata with the oral alpha-1 adrenoceptor antagonist, doxazosin

Batchelor, R. J.; Lyon, Corey; Highet, A.S.

doi:10.1111/j.0007-0963.2004.05880.x

Cited by 31 publications

(19 citation statements)

References 7 publications

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“…Leiomyoma associated pain can be managed medically with drugs known to affect smooth muscle contraction, such as nitroglycerine, nifedipine, phenoxybenzamine, and doxazosin; recent reports also suggest the use of calcium channel blockers, botulinum toxin type A injections, antidepressants, and triamcinolone acetonide injections [18,19]. For temperature-induced tenderness, gabapentin and topical analgesics, such as lidocaine or capsaicin, may be used [20,21].…”

Section: Discussionmentioning

confidence: 99%

Pilar Leiomyoma Located on the Back: A Case Report

Elgendy¹,

Alshawadfy²,

Ali³

2015

J Clin Exp Dermatol Res

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Leiomyoma is a benign tumour commonly encountered in the genitourinary and gastrointestinal organs in adults. Cutaneous leiomyomas are rare benign tumors arising from the arrector pili muscle of hair follicles. Cutaneous leiomyomas are more likely to occur in adults than in children. We describe a case of a 30-year-old male who presented with skin-coloured masses on the back. A punch biopsy was performed. Under high-power examination, spindle cells with an eosinophilic cytoplasm were observed and immunohistochemical studies were performed; the cells stained strongly positive for smooth muscle actin (SMA). The patient was subsequently diagnosed with pilar leiomyoma and referred to a plastic surgeon for surgical treatment. A careful clinical assessment led to the correct diagnosis and therapy in the present case.

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Section: Discussionmentioning

confidence: 99%

Pilar Leiomyoma Located on the Back: A Case Report

Elgendy¹,

Alshawadfy²,

Ali³

2015

J Clin Exp Dermatol Res

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“…However, in the presence of numerous scattered lesions or large confluent areas of involvement, as in our clinical case, surgery and CO 2 laser treatment should not be considered. Rather, various pharmacological options have been reported [6,7,8,9,10]. Nifedipine, phenoxybenzamine, nitroglycerine, phenoxybenzamine, doxazosin, gabapentin, tramadol, pregabalin, duloxetine, analgesic-antipyretic, and botulinum toxin type A treatment, alone or in combination, have been administered with low and variable success.…”

Section: Discussionmentioning

confidence: 99%

“…These treatments included the administration of nifedipine along with hyoscine butylbromide, nitroglycerine, phenoxybenzamine, doxazosin, gabapentin alone or in combination with tramadol, an analgesic-antipyretic, a combination of pregabalin and duloxetine, and botulinum toxin type A, as reported in the literature [6,7,8,9,10]. A visual analogue scale was used to measure changes in the patient's level of pain.…”

Section: Case Reportmentioning

confidence: 99%

Treatment of a Patient with Multiple Cutaneous Piloleiomyoma-Related Pain with a Local Injection of Triamcinolone Acetonide

Liu¹,

Tang²,

Hong³

et al. 2013

Dermatology

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Background: Multiple cutaneous piloleiomyomas are rare, frequently painful and difficult-to-treat benign tumours originating in the arrectores pilorum muscles of the hair follicles. Objective: The aim of this study was to determine the efficacy of a local injection of triamcinolone acetonide in relieving cutaneous piloleiomyoma-related pain. Methods: A patient with multiple painful piloleiomyomas was treated with weekly local injections of triamcinolone acetonide into the nodules and papules for 3 weeks. Results: The patient's nodules and papules became smaller, and the pain disappeared. At 1-year follow-up, there were no side effects, pain recurrence or significant enlargement of any of the injected lesions. Conclusion: Our study demonstrates that local injection of triamcinolone acetonide may be a promising new treatment option for multiple painful cutaneous piloleiomyomas.

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“…Ancak, çok lezyonu olan hastalarda eksizyon sonrası nüks riskinin yüksek olması da dikkate alındığında genel yaklaşım, hastayı semptomatik olarak rahatlatmak olmalıdır. Bu amaçla parasetamol grubu analjezikler, amitiriptilin, alfa adrenerjik reseptör blokerleri, kalsiyum kanal blokeri nifedipin, gabapentin, sempatikolizis ya da iyontoferezis kullanılabilir (3,(9)(10)(11)(12). Hastamızın şiddetli ağrılarına yönelik olarak, amitriptilin, parasetamol, gabapentin, tramadol hidroklorür kombinasyonu başlandı.…”

Section: Discussionunclassified

Leiomyomatosis Cutis

Ürkmez¹,

Ertam²,

Karaarslan³

et al. 2011

Turk J Dermatol

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IV. Ege Dermatoloji Günleri'nde poster sunumu yapılmıştır. ÖzetLeiyomyomatozis kutis, düz kas hücrelerinden kaynaklanan, genellikle alt ekstremitede yerleşen, oval şekilli, kırmızı-kahverenkli, papülonodüler lezyonlarla karakterize nadir görülen bir hastalıktır. Elli üç yaşındaki kadın hasta vücutta çok sayıda ağrılı kabarıklık yakınmasıyla polikliniğimize başvurdu. Özgeçmişinde iskemik atak, uterin leiyomyom nedeni ile total histerektomi, sağ ooferektomi operasyonu, nefrolitiazis ve renal kist hikayesi mevcuttu. Dermatolojik bakısında sırtta sol skapular alanda, bilateral gluteal ve alt ekstremitelerde ağrılı, kırmızı-kahverenkli, gruplar halinde dağılım gösteren çok sayıda papülonodüler lezyonlar izlendi. Lezyondan alınan biyopsinin histopatolojik incelemesi ile leiyomyom tanısı kondu. Ağrıya yönelik olarak başlanan gabapentin, parasetamol, tramadol hidroklorür ve amitriptilin tedavisi ile üç hafta sonunda semptomlarda kısmi düzelme sağlandı. Hastamız ülkemizden bildirilen ilk leiyomyomatozis kutis olgu bildirisi olma özelliğindedir. ( AbstractLeiomyomatosis cutis is a rare disease characterized by oval shaped, red-brown follicular groups of papulonodular lesions especially located on the lower limbs, in which the lesions originate from smooth muscle cells. A fifty-three-year-old female patient was admitted to our clinic with multiple painful nodules on the body. An ischemic stroke, total hysterectomy for leiomyoma, oopherectomy, nephrolitiasis and renal cysts were present in her past medical history. Dermatologic examination revealed multiple, painful, red-brown nodules forming clusters on the left scapular area, bilateral gluteal area and lower limbs. Histopathological examination of the lesional biopsy diagnosed as leiomyoma. Treatment started with gabapentin, paracetamol, tramadol hydrochloride and, amitriptyline, which produced relief of the pain at the end of three weeks. To the best of our knowledge, this is the first case report in our country. (Turk J Dermatol 2011; 5: 101-3)

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Successful treatment of pain in two patients with cutaneous leiomyomata with the oral alpha-1 adrenoceptor antagonist, doxazosin

Cited by 31 publications

References 7 publications

Pilar Leiomyoma Located on the Back: A Case Report

Pilar Leiomyoma Located on the Back: A Case Report

Treatment of a Patient with Multiple Cutaneous Piloleiomyoma-Related Pain with a Local Injection of Triamcinolone Acetonide

Leiomyomatosis Cutis

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