Background: Despite advances in acne therapy, treatment failure is still common. Isotretinoin is the only drug that affects almost all factors in acne pathogenesis, however side-effects are common at the doses reported in published studies in the literature. Sun exposure is known to be beneficial for acne. Lasers/light-based devices may offer an alternative to conventional acne modalities in selected patients, such as non-responder or noncompliant patients or in antibiotic resistant patients. The aim of the study was to compare the efficacy of blue light and low dose isotretinoin in patients with mild to moderate acne.
Pseudoxanthoma elasticum (PXE) is a hereditary disorder that mainly involves the skin, eyes, and cardiovascular system.We reported a case of pseudoxanthoma elasticum with involvement of neck, axillae, abdomen and thighs, together with angioid streaking of fundi. Skin biopsy specimen was taken and was stained with hematoxylin and eosin (H and E) that revealed fragmentation of the elastic fibers. These features were suggestive of histopathological diagnosis of PXE.We have reviewed other published reports to obtain a better understanding of the genetics, histopathology, vascular and ophthalmological manifestations of pseudoxanthoma elasticum.
Pathogenetic mechanisms of CVD in psoriasis patients appear to be of a complex nature and remain unclear. The development of atherosclerosis and its increased prevalence may be partially explained by the presence of atherosclerotic risk factors, e.g., diabetes, hypertension, obesity, and hyperlipidemia as well as by the chronic inflammatory processes that are commonly observed in psoriasis (Figure 1) [11] Both of these pathological conditions involve genetic, immunological, and environmental factors, which may modify the clinical expression of psoriasis and atherosclerosis substantially [10,12]
Leiomyoma is a benign tumour commonly encountered in the genitourinary and gastrointestinal organs in adults. Cutaneous leiomyomas are rare benign tumors arising from the arrector pili muscle of hair follicles. Cutaneous leiomyomas are more likely to occur in adults than in children. We describe a case of a 30-year-old male who presented with skin-coloured masses on the back. A punch biopsy was performed. Under high-power examination, spindle cells with an eosinophilic cytoplasm were observed and immunohistochemical studies were performed; the cells stained strongly positive for smooth muscle actin (SMA). The patient was subsequently diagnosed with pilar leiomyoma and referred to a plastic surgeon for surgical treatment. A careful clinical assessment led to the correct diagnosis and therapy in the present case.
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