“…Destructive methods such as electrodessication, cryotherapy, or carbon-dioxide laser may be employed for small lesions, but there is little known benefit over excision, and unwanted scarring may occur [16,17]. Leiomyoma associated pain can be managed medically with drugs known to affect smooth muscle contraction, such as nitroglycerine, nifedipine, phenoxybenzamine, and doxazosin; recent reports also suggest the use of calcium channel blockers, botulinum toxin type A injections, antidepressants, and triamcinolone acetonide injections [18,19]. For temperature-induced tenderness, gabapentin and topical analgesics, such as lidocaine or capsaicin, may be used [20,21].…”