“…However, in the presence of numerous scattered lesions or large confluent areas of involvement, as in our clinical case, surgery and CO 2 laser treatment should not be considered. Rather, various pharmacological options have been reported [6,7,8,9,10]. Nifedipine, phenoxybenzamine, nitroglycerine, phenoxybenzamine, doxazosin, gabapentin, tramadol, pregabalin, duloxetine, analgesic-antipyretic, and botulinum toxin type A treatment, alone or in combination, have been administered with low and variable success.…”