Successful Lung Transplantation in a Patient with Chronic Granulomatous Disease

Stenotrophomonas maltophilia: An Emerging Pathogen in Chronic Granulomatous Disease

“…Infections due to S. maltophilia are not commonly reported in patients with IEI, probably due to the frequent use of cotrimoxazole prophylaxis in these patients. In the literature search, we identified only 8 cases of IEI who developed S. maltophilia infection and 5 of them had CGD [3][4][5][6][7] (see 4 One patient with CGD had bronchial colonization with S. maltophilia secondary to bronchiectasis and he subsequently required lung transplantation. 6 We have isolated S. maltophilia in 3 patients (1-blood-stream and 2-pulmonary) with CGD in the last 1 year.…”

“…In the literature search, we identified only 8 cases of IEI who developed S. maltophilia infection and 5 of them had CGD [3][4][5][6][7] (see 4 One patient with CGD had bronchial colonization with S. maltophilia secondary to bronchiectasis and he subsequently required lung transplantation. 6 We have isolated S. maltophilia in 3 patients (1-blood-stream and 2-pulmonary) with CGD in the last 1 year. Among the pulmonary infections, 1 child (patient 2) had a chronic lung disease and the other (patient 3) had concomitant disseminated tuberculosis and succumbed to the illness.…”

“…maltophilia are not commonly reported in patients with IEI, probably due to the frequent use of cotrimoxazole prophylaxis in these patients. In the literature search, we identified only 8 cases of IEI who developed S. maltophilia infection and 5 of them had CGD 3–7 (see Table, Supplemental Digital Content 4, http://links.lww.com/INF/F10). A large cohort of 93 patients with CGD from Mexico has identified only 2 patients with S. maltophilia infection; however, clinical details and susceptibility patterns were not available.…”

“…of S. maltophilia infections in patients with CGD, however; overall only 5 patients have been reported so far. [4][5][6][7] We have isolated S. maltophilia recently in 3 of our patients with CGD. Surprisingly, we have not isolated this organism in other primary immunodeficiency groups in our cohort.…”

“…There are isolated reports of S. maltophilia infections in patients with CGD, however; overall only 5 patients have been reported so far. 4–7…”