Stenotrophomonas maltophilia: An Emerging Pathogen in Chronic Granulomatous Disease

Aggarwal, Ridhima; Mondal, Sanjib; Angrup, Archana; Vignesh, Pandiarajan; Rawat, Amit

doi:10.1097/inf.0000000000003927

Cited by 1 publication

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S. maltophilia is not common in IEI, and the susceptibility pattern is unclear. A recent study suggested that the S. maltophilia infection rate in CGD patients was higher than in other types of immunodeficiency [42] . However, no CGD patients had S. maltophilia infection in our study.…”

Section: Discussionmentioning

confidence: 93%

The spectrum of bacterial infectionin a large cohort of Chinese pediatric patients with inborn errors of immunity: a nine-year, retrospective, single-center study

Zhu,

Fu,

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

Inborn errors of immunity (IEI) patients with different immune component deficiencies are susceptible to different bacteria. This study aimed to investigate the spectrum of bacterial infection in different classifications of IEI in children. Pediatric patients diagnosed with IEI and detected positive for bacteria considered to be pathogenic were included in this retrospective study. In this study, 1818 medical charts of IEI inpatients were reviewed, and 291 hospitalizations were enrolled, including 244 IEI patients. A total of 363 strains were detected, of which, 84 (23.14%) were gram-positive bacteria, and 279 (76.86%) were gram-negative bacteria. The main bacteria isolated from different IEI classifications were different. Klebsiella pneumoniae (12.68%) and Pseudomonas aeruginosa (12.68%) were most isolated from combined immunodeficiencies. Haemophilus influenzae (31.86%) and Moraxella catarrhalis (14.16%) were most isolated from predominant antibody deficiencies. K. pneumoniae (15.68%) and Escherichia coli (11.89%) were most isolated from congenital defects of phagocytes. Specific bacteria had susceptible classifications of IEI. H. influenzae was often isolated in predominant antibody deficiencies (7.83%), Salmonella was often isolated in defects in intrinsic and innate immunity (4.28%), and Staphylococcus aureus was often isolated in combined immunodeficiencies with syndromic features (5.77%). The ratios of methicillin-resistant S. aureus, carbapenem-resistant E. coli, K. pneumoniae, P. aeruginosa, and Acinetobacter baumannii in IEI patients were 55.17%, 38.10%, 25.71%, 25.81%, and 70.59%, respectively, which were higher than those in non-IEI patients. The IEI in children defines a unique and specific spectrum of bacterial infections. Isolated bacteria from children with IEI have high antimicrobial resistance.

show abstract

Section: Discussionmentioning

confidence: 93%