Subthalamic gamma activity in patients with Parkinson's disease

Trottenberg, Thomas; Fogelson, Noa; Kühn, Andrea A.; Kivi, Anatol; Kupsch, Andreas; Schneider, Gerd‐Helge; Brown, Peter

doi:10.1016/j.expneurol.2006.01.012

Cited by 89 publications

(51 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This frequency range (14 -35 Hz) extends a little higher than in previous publications, but the extension of the band is further justified by two studies that include the extent of spectral peaks in individual nuclei. In these, STN LFP spectra in 5 of 16 (Kühn et al, 2004) and 13 of 26 (Trottenberg et al, 2006). The definition of a broad "sub-␤ band" (3-13 Hz) that includes and ␣ bands was motivated by the need to preserve statistical power.…”

Section: Methodsmentioning

confidence: 99%

Patterns of Bidirectional Communication between Cortex and Basal Ganglia during Movement in Patients with Parkinson Disease

Lalo

Thobois²,

Sharott³

et al. 2008

J. Neurosci.

221

174

View full text Add to dashboard Cite

Cortico-basal ganglia networks are considered to comprise several parallel and mostly segregated loops, where segregation is achieved in space through topographic connectivity. Recently, it has been suggested that functional segregation may also be achieved in the frequency domain, by selective coupling of related activities at different frequencies. So far, however, any coupling across frequency in the human has only been modeled in terms of unidirectional influences, a misplaced assumption given the looped architecture of the basal ganglia, and has been considered in static terms. Here, we investigate the pattern of bidirectional coupling between mesial and lateral cortical areas and the subthalamic nucleus (

show abstract

Section: Methodsmentioning

confidence: 99%

Patterns of Bidirectional Communication between Cortex and Basal Ganglia during Movement in Patients with Parkinson Disease

Lalo

Thobois²,

Sharott³

et al. 2008

J. Neurosci.

221

174

View full text Add to dashboard Cite

show abstract

“…Gamma-band activity also was described in the basal ganglia (Trottenberg et al 2006), cerebellum (Lang et al 2006), and hippocampus (Charpak et al 1995;Chrobak and Buzsáki 1998). Coherent gamma frequencies occur between the thalamus and cortex (Pedroarena and Llinas 2001), cortex and cerebellum (Soteropoulos and Baker 2006), cerebellum and thalamus (Timofeev and Steriade 1997), and hippocampus and cortex (Buzsáki 2006).…”

mentioning

confidence: 99%

Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder

D’Onofrio

Kezunovic

Hyde

et al. 2015

Journal of Neurophysiology

View full text Add to dashboard Cite

D'Onofrio S, Kezunovic N, Hyde JR, Luster B, Messias E, Urbano FJ, Garcia-Rill E. Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder. J Neurophysiol 113: 709 -719, 2015. First published November 5, 2014 doi:10.1152/jn.00828.2014.-Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1. We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with overexpression, decrease gammaband activity. We found that PPN neurons in rat brain slices manifested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1. Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.

show abstract

“…Recientemente se ha demostrado que el parkinsonismo está relacionado a una hiperactividad del NST con hipersincronización de las oscilaciones de baja frecuencia entre el NST y el Globo Pálido (GP), lo que de alguna forma interfi ere con la capacidad de iniciar o detener programas motores en la corteza [14][15][16][17][18][19] . También se ha sugerido que el parkinsonismo puede relacionarse a cambios neuroplásticos de la vía directa como consecuencia de la denervación dopaminérgica, sobre todo a nivel del estriado y en los núcleos de salida de los GB (SNpr/GPi).…”

Section: A Enfermedad De Parkinson Idiopática (Epi) Esunclassified

El núcleo subtalámico en la fisiopatología de la enfermedad de Parkinson y su rol como diana quirúrgica

Méndez-Herrera

2011

Rev. chil. neuro-psiquiatr.

View full text Add to dashboard Cite

Subthalamic gamma activity in patients with Parkinson's disease

Cited by 89 publications

References 31 publications

Patterns of Bidirectional Communication between Cortex and Basal Ganglia during Movement in Patients with Parkinson Disease

Patterns of Bidirectional Communication between Cortex and Basal Ganglia during Movement in Patients with Parkinson Disease

Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder

El núcleo subtalámico en la fisiopatología de la enfermedad de Parkinson y su rol como diana quirúrgica

Contact Info

Product

Resources

About