Patterns of Bidirectional Communication between Cortex and Basal Ganglia during Movement in Patients with Parkinson Disease

Lalo, Elodie; Thobois, Stéphane; Sharott, Andrew; Polo, Gustavo; Mertens, Patrick; Pogosyan, Alek; Brown, Peter

doi:10.1523/jneurosci.5295-07.2008

Cited by 227 publications

(207 citation statements)

References 44 publications

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“…The frontocentral topography of the beta-gamma component observed in the present study for positive feedbacks is compatible with the ventromedial prefrontal activations reported in studies on reward and punishment processing (Kim, Shimojo, & O'Doherty, 2006;Knutson, Fong, Bennett, Adams, & Hommer, 2003;Nieuwenhuis, Slagter, von Geusau, Heslenfeld, & Holroyd, 2005;Tom, Fox, Trepel, & Poldrack, 2007). A follow-up study has also suggested the possible dopaminergic origin of the beta-gamma activity (Marco-Pallarès et al, 2009), in convergence with recent studies showing that changes in dopamine levels are associated with the reestablishment of gamma band oscillations and a change from low-to high-oscillatory activity (Brown et al, 2001;Lalo et al, 2008).…”

Section: Discussionsupporting

confidence: 92%

Brain oscillatory activity associated with task switching and feedback processing

Cunillera

Fuentemilla

Periáñez

et al. 2011

Cogn Affect Behav Neurosci

102

100

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In this study, we sought to dissociate eventrelated potentials (ERPs) and the oscillatory activity associated with signals indicating feedback about performance (outcome-based behavioral adjustment) and the signals indicating the need to change or maintain a task set (rule-based behavioral adjustment). With this purpose in mind, we noninvasively recorded electroencephalographic signals, using a modified version of the Wisconsin card sorting task, in which feedback processing and task switching could be studied separately. A similar late positive component was observed for the switch and correct feedback signals on the first trials of a series, but feedbackrelated negativity was observed only for incorrect feedback. Moreover, whereas theta power showed a significant increase after a switch cue and after the first positive feedback of a new series, a selective frontal beta-gamma increase was observed exclusively in the first positive feedback (i.e., after the selection of the new rule). Importantly, for the switch cue, beta-alpha activity was suppressed rather than increased. This clear dissociation between the cue and feedback stimuli in task switching emphasizes the need to accurately study brain oscillatory activity to disentangle the role of different cognitive control processes.

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Section: Discussionsupporting

confidence: 92%

Brain oscillatory activity associated with task switching and feedback processing

Cunillera

Fuentemilla

Periáñez

et al. 2011

Cogn Affect Behav Neurosci

102

100

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“…Last, given the dense connections between the CMA and the BG [particularly the anterior putamen (McFarland and Haber, 2000;Takada et al, 2001)] and given the detrimental effect of dopamine depletion on corticostriatal connectivity (Lalo et al, 2008), we directly tested whether effective connectivity between these structures would change as a function of disease severity. Switch-related effective connectivity between the CMA and the most affected BG significantly decreased as a function of lateralized disease severity (left GP, r ϭ Ϫ0.71, p ϭ 0.039 corrected, local maximum at [Ϫ20 4 2]; left putamen, r ϭ Ϫ0.80, p ϭ 0.007 Figure 3.…”

Section: Relationship Between Cerebral Effects and Disease Severitymentioning

confidence: 99%

Increased Dependence of Action Selection on Recent Motor History in Parkinson's Disease

Helmich

Aarts²,

Lange³

et al. 2009

J. Neurosci.

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It is well known that the basal ganglia are involved in switching between movement sequences. Here we test the hypothesis that this contribution is an instance of a more general role of the basal ganglia in selecting actions that deviate from the context defined by the recent motor history, even when there is no sequential structure to learn or implement. We investigated the effect of striatal dopamine depletion [in Parkinson's disease (PD)] on the ability to switch between independent action plans. PD patients with markedly lateralized signs performed a hand laterality judgment task that involved action selection of their most and least affected hand. Trials where patients selected the same (repeat) or the alternative (switch) hand as in a previous trial were compared, and this was done separately for the most and least affected hand. Behaviorally, PD patients showed switch-costs that were specific to the most affected hand and that increased with disease severity. Functional magnetic resonance imaging (fMRI) showed that this behavioral effect was related to the state of the frontostriatal system: as disease severity increased, contributions of the basal ganglia to the selection process and their effective connectivity with the medial frontal cortex (MFC) decreased, whereas involvement of the MFC increased. We conclude that the basal ganglia are important for rapidly switching toward novel motor plans even when there is no sequential structure to learn or implement. The enhanced MFC activity may result either from reduced focusing abilities of the basal ganglia or from compensatory processes.

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“…Coherent gamma frequencies occur between the thalamus and cortex (Pedroarena and Llinas 2001), cortex and cerebellum (Soteropoulos and Baker 2006), cerebellum and thalamus (Timofeev and Steriade 1997), and hippocampus and cortex (Buzsáki 2006). Gamma activity in the motor cortex lags behind coherent activity in subcortical structures (Lalo et al 2008;Litvak et al 2012), suggesting that gamma synchronization reflects an arousal-related event for enabling initiation of movement (Brucke et al 2012;Cheyne and Ferrari 2013;Jenkinson et al 2013). In addition, we showed that every cell in the reticular activating system (RAS), especially the pedunculopontine nucleus (PPN), plateaus at gamma frequencies (Kezunovic et al 2011;Simon et al 2010;Urbano et al 2012).…”

mentioning

confidence: 99%

Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder

D’Onofrio

Kezunovic

Hyde

et al. 2015

Journal of Neurophysiology

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D'Onofrio S, Kezunovic N, Hyde JR, Luster B, Messias E, Urbano FJ, Garcia-Rill E. Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder. J Neurophysiol 113: 709 -719, 2015. First published November 5, 2014 doi:10.1152/jn.00828.2014.-Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1. We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with overexpression, decrease gammaband activity. We found that PPN neurons in rat brain slices manifested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1. Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.

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Patterns of Bidirectional Communication between Cortex and Basal Ganglia during Movement in Patients with Parkinson Disease

Cited by 227 publications

References 44 publications

Brain oscillatory activity associated with task switching and feedback processing

Brain oscillatory activity associated with task switching and feedback processing

Increased Dependence of Action Selection on Recent Motor History in Parkinson's Disease

Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder

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