El núcleo subtalámico en la fisiopatología de la enfermedad de Parkinson y su rol como diana quirúrgica

The preventive and therapeutic role of physical exercise in Parkinson's disease (PD) has been the target of study of many scientific groups, and the research often is done in experimental models, especially rodents. Thus, the aim of this review was to analyze a database, elucidating the main benefits that the systematized practice of physical activity/ exercises can contribute to PD in animal models. Method: Based on this question, a search on PubMed and Medline database containing the terms: "Parkinson's disease" AND "animal model" AND "physical exercise" was performed. The most pertinent studies were selected by the criteria year of publication (2009-2018) and the original article. It was used papers involving animal models and physical exercises, as well as other studies, which allowed an introductory explanation in PD, covering its pathophysiology, and the neurochemical responses of physical exercise in rodents. Results: The results showed that there was a decrease in the levels of nigrostriatal neurodegeneration and an increase in the neuroprotective effect related to the training program. Conclusion: It was concluded that physical exercise has been pointed as an important neuroprotective strategy in animal models of Parkinson's disease, especially those applied at moderate intensities, which were effective in reducing the inflammatory profile, elevating the expression of genes and proteins related to neuronal restoration, mitochondrial biogenesis, repair of the dopaminergic system, besides other events also capable of reflecting improvements in motor and cognitive behavior of animals.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

El núcleo subtalámico en la fisiopatología de la enfermedad de Parkinson y su rol como diana quirúrgica

Cited by 2 publications

References 44 publications

Tratamiento fisioterapéutico de las alteraciones posturales en la enfermedad de Parkinson. Revisión sistemática

Tratamiento fisioterapéutico de las alteraciones posturales en la enfermedad de Parkinson. Revisión sistemática

Benefits of physical exercise on Parkinson’s disease disorders induced in animal models

Contact Info

Product

Resources

About