Substrate Independent Liquid Phase Epitaxy of HKUST‐1 as Anticoagulant and Antimicrobial Coating

Abstract

The effective deposition of metal–organic frameworks on kinds of biomaterials is still challenging and highly desirable. Using polydopamine as the effective nucleation center, HKUST‐1 is successfully prepared on three kinds of inert biomaterials, i.e., titanium oxide film (Ti–O), 316L stainless steel (316L SS), and poly(vinyl chloride) (PVC). Characterization of the surfaces by powder X‐ray diffraction confirm the oriented crystal growth of HKUST‐1 on the polydopamine coated substrates. There are no significant difference in catalytical NO generation and surface copper content of the three samples with HKUST‐1 deposition. All keep a NO release speed of ≈2.5 × 10−10 mol cm−2 min−1, thus platelet activation on the HKUST‐1 modified surfaces are inhibited compared to that of the unmodified ones. Ex vivo test shows thrombi formation is dramatically reduced. The HKUST‐1 coated surfaces elicit 95% reduction in the bacterial attachment of both Staphylococcus aureus and Escherichia coli. The endothelial cells and macrophages culture results support good biocompatibility of the modified surfaces. It provides a promising, facile, and effective approach for surface modification of blood contact biomaterials.

Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix

“…Such a system reduced the Cu(II) toxicity and enhanced the wound healing process for diabetic mice by promoting a plethora of processes such as cell migration, angiogenesis and collagen deposition [ 74 ]. This compound, embedded in PVC, reduced the bacterial attachment of both S. aureus and E. coli strains [ 75 ].…”

“…The bacc [Cu 3 (btc) 2 ] ( 17 ), embedded in titanium oxide film and 316L stainless steel as materials with a good biocompatibility with both endothelial and macrophages cells, inhibited the bacterial adhesion of both S. aureus and E. coli strains [ 75 ]. The same species immobilized on titanium foils exhibited ideal NO release and a synergistic role of NO and Cu(II) in inhibiting platelet activation, suppressing macrophages adhesion and proliferation in order to reduce hyperplasia.…”

“…healing in diabetic mice Biofilm of S. aureus, E. coli inhibition Cell migration, angiogenesis and collagen deposition[74,75] …”

Facile fabrication of copper-incorporating poly(ε-caprolactone)/keratin mats for tissue-engineered vascular grafts with the potential of catalytic nitric oxide generation

“…13 Zhang et al assembled HKUST-1 on polydopamine coated substrates, which not only notably improved the anticoagulant properties by the catalytic generation of antithrombotic NO but also endowed the materials with excellent antibacterial activity. 14 Recently, Zhang et al prepared poly(ε-caprolactone) (PCL)/copper-MOF composite vascular grafts for sustained NO generation and long-term vascular patency. 15 Li et al prepared a polyphenol-Cu( ii ) ion coating to catalyze the continuous generation of NO by RSNOs, thereby improving the inhibition of microorganisms and pro-vascularization activities.…”

Laser‐Triggered Interfacial Generation of ROS Promotes a Rapid Fabrication of Polydopamine Coating

“…It is usually prepared in an alkaline aqueous environment at room temperature, [6] and can deposit on versatile surfaces. [7][8][9] Through Michael addition/Schiff base reaction or chelation DOI: 10.1002/mame.202100987 interactions, the residual catechol and amine groups of PDA coatings serve as anchoring points for multiple species, including peptides, [10] growth factor, [11] heparin, [12] initiators, [13] silver nanoparticles, [14] or titanium dioxide. [15] The facile preparation and post-modification ability make it an ideal choice for fabricating functional coatings on various matrices.…”