Laser‐Triggered Interfacial Generation of ROS Promotes a Rapid Fabrication of Polydopamine Coating

Abstract

Mussel-inspired polydopamine (PDA) coating has been proved to be a universal surface modification strategy with remarkable versatility and active post-modification ability. However, the traditional preparation of PDA coating shows low polymerization efficiency and alkaline environment dependency. Herein, a robust method to accelerate the in situ generation of PDA coating based on a photosensitizer entrapped substrate is reported. It is demonstrated that the chlorin e6 (Ce6)-incorporated substrates induce sustained reactive oxygen species (ROS) production via laser irradiation at 660 nm, which dramatically promotes the preparation of PDA coating even in acidic conditions. The thickness of the PDA coating reaches over 4 nm with only 10 min irradiation (pH 6). Patterned PDA coatings can also be achieved by using a photomask. The functionality of this interfacial ROS-induced PDA coating including photothermal ability and secondary modification ability is also verified. The obtained PDA coating realizes the reduction of Ag + to Ag NPs, which shows excellent antibacterial ability. This interfacial ROS generation strategy offers a facile and efficient way to construct the PDA coating and expands the potential applications in the biomedical field.