Facile fabrication of copper-incorporating poly(ε-caprolactone)/keratin mats for tissue-engineered vascular grafts with the potential of catalytic nitric oxide generation

Abstract

Tissue-engineered vascular graft (TEVG) provides a new alternative for vascular construction. Nitric oxide (NO) is capable of promoting vascular tissue regeneration and reducing restenosis caused by vascular implantation. Therefore, in...

Bilayer vascular grafts with on-demand NO and H2S release capabilities

“…Zhang et al incorporated copper-MOFs for sustained nitric oxide generation and long-term vascular patency [ 19 ]. Miao et al fabricated copper-incorporated poly (ε-caprolactone)/keratin mats for tissue-engineered vascular grafts with the potential of catalytic nitric oxide generation [ 20 ]. More importantly, the release rate of NO can be regulated by adjusting the Cu(II) ion content, achieving controlled NO release.…”

Endothelium-Mimicking Bilayer Vascular Grafts with Dual-Releasing of NO/H2S for Anti-Inflammation and Anticalcification

“…9−11 In previous works, we have prepared a series of small-caliber vascular tissue engineering grafts based on the excellent biological properties of keratin to achieve long-term patency and rapid endothelialization in vivo implantation. 12,13 Hydrogen sulfide (H 2 S) and nitric oxide (NO) are significant gasotransmitters with intrinsic biochemical properties, which exert various physiological effects under both normal and pathological conditions. 14,15 Endogenous H 2 S is involved in anti-inflammatory, cardioprotection, neuromodulation, metabolic inhibition, antioxidant response, vasodilatation and antihypertensive effects, pro-angiogenic effects, and cytoprotection.…”

“…Chen et al constructed vascular grafts loaded with enzymes (Apyrase and 5′-nucleotide enzyme) using hyaluronic acid as the substrate to improve antiplatelet ability and endothelialization . Keratin contains cell-binding motifs of RGD and LDV, which beneficial to the adhesion and migration of cells. , The structure of keratin extracted by reduction contains thiols, carboxyl, and amino acids, which facilitate the combination of keratin with functional chemical small molecules. − In previous works, we have prepared a series of small-caliber vascular tissue engineering grafts based on the excellent biological properties of keratin to achieve long-term patency and rapid endothelialization in vivo implantation. , …”