Substituted 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones as urease inhibitors

Тарун, Е. И.; Zheldakova, T. A.; Metelitza, D. I.

doi:10.1134/s1990750809010107

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Tarun et al 66 reported several substituted 1,5,6,7‐tetrahydro‐4 H ‐benzimidazol‐4‐ones as potential urease inhibitors. Most of the tested compounds showed promising results.…”

Section: Classes Of Urease Inhibitorsmentioning

confidence: 99%

Structurally Diversified Heterocycles and Related Privileged Scaffolds as Potential Urease Inhibitors: A Brief Overview

Ibrar

Khan

Abbas

2013

Archiv der Pharmazie

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Ureases have emerged as significant virulence factors implicated in the pathogenesis of many clinical conditions such as pyelonephritis, hepatic coma, peptic ulceration, and the formation of injection-induced urinary stones and stomach cancer. They have also been identified as important targets in research both for human and animal health, as well as in agriculture. Strategies based on urease inhibition are the main treatment of diseases caused by urease-producing bacteria. So, in the present context, a diverse library of chemical structures is known to possess remarkable inhibitory activities against urease enzymes. The current review article summarizes and discusses endeavours towards the developments in the burgeoning field of urease inhibition in medicinal chemistry, with an emphasis on the insights that have been gleaned into the structural features that contribute to high and promising levels of anti-urease activity.

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“…Tarun et al 66 reported several substituted 1,5,6,7‐tetrahydro‐4 H ‐benzimidazol‐4‐ones as potential urease inhibitors. Most of the tested compounds showed promising results.…”

Section: Classes Of Urease Inhibitorsmentioning

confidence: 99%

Structurally Diversified Heterocycles and Related Privileged Scaffolds as Potential Urease Inhibitors: A Brief Overview

Ibrar

Khan

Abbas

2013

Archiv der Pharmazie

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“…Ингибиторы уреазы, как добавки к удобрениям, блокируют деятельность фермента уреазы, выделяемый уреабактериями и корнями растений, в зоне контакта удобрения с почвенным раствором [5]. Фермент уреаза превращает молекулу мочевины в гидрокарбонат аммония -соединение весьма нестабильное, распадающееся с образованием свободного аммиака, который теряется в атмосферу.…”

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Effectiveness of Urea With Urease Inhibitor – Utec to the Potato

Сычёв¹,

Akanova²,

Визирская³

2019

Ovoŝi Rossii

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In the he article are presented the research result on effectiveness of application new form of urea on potato. New urea form is urea with urease inhibitors. This fertilities type allow to reduce losses of nitrogen in ammonium form. Field experiment was carried out in 2017 on solonetc light chestnut soils with heavy granulometric compound in the conditions of the Volgograd region in the experimental polygon of the lower Volga agricultural research Institute – branch of Federal state budgetary scientific institution "Federal scientific center for agro-ecology, integrated land reclamation and protective afforestation wounds". As an object of research used potatoes mid-early table varieties Nevsky. The advantage of a new fertilizer form is the yield increase and improvement of tubers quality. Urea UTEC application leads to formation bigger and uniform tuber size. The use of urea UTEC provide the potato yield of 56.4 t/ha, with marketable tubers fraction up to 54.82 t/ha, the total yield increase to the control – 35.6%, in monetary terms this amounted to 245887.0 RUB/ha additional profit. Under these conditions, was obtained lowest amount of non-marketable yield – 0.16 t/ha, which is 2.65 times less than in the control variant. The advantage of urea UTEC application in comparison with ammonium nitrate was the increase in the yield of marketable potatoes by 5.1 t/ha and an additional profit up to 76.8 thousand rubles/ha. The Assessment of the potato quality showed that the best treatment was also the treatment with UTEC urea, the starch content in tubers was 9.22%. Note that almost the same value of the indicator in the variant with the use of urea (option 2), and the lowest starch content was noted when using ammonium nitrate – 9.05%.

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Substituted 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones as urease inhibitors

Cited by 2 publications

References 9 publications

Structurally Diversified Heterocycles and Related Privileged Scaffolds as Potential Urease Inhibitors: A Brief Overview

Structurally Diversified Heterocycles and Related Privileged Scaffolds as Potential Urease Inhibitors: A Brief Overview

Effectiveness of Urea With Urease Inhibitor – Utec to the Potato

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