Submaxillary and Retrolingual Gland Hypertrophy by Different Incisor Amputations in the Rat

Cj, Perec; Ab, Houssay; Aa, Peronace; Jf, Deharfin

doi:10.1177/00220345650440041401

Cited by 19 publications

(6 citation statements)

References 8 publications

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“…Atnputation of the erupted portion of the lower ineisor teeth of rats results in a tnarked increase in weight of the subrnandibular and sublingual salivary glands (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). The enlargement of the salivary glatids depends upon the continued stimulus of repeated amputation (4).…”

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confidence: 99%

Enlargement of rat submandibular salivary gland induced by single amputation of lower incisor teeth

Takeda

Enomoto²

1986

J Oral Pathology Medicine

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Takeda Y. Flirose H. Enomoto S. Enlargement of rat submandibular salivary gland indtrced by single amputation of lower incisor teeth, J Oral Pathol 1986: 15: 327-333.Histological. histomctrie and ultrastructural studies of rat subtnandibular salivary glands (SMG) lollowitig single amputation of lower incisor teeth were made. The SMG enlargement oeeurred after the tooth amputation, and its maximal increase of weight was reached 7 days later. The results of histological and histomctric observations showed that the enlargement of SMG was due to both hypertrophy and hyperplasia of the aeinar eells. and hypertrophie acinar cells were ultrastrueturally eharaeterized by well-developed organelles sueh as rough-surfaced endoplasmie reticulum and Golgi apparatus whieh filled the eittire cytoplasm. Hydropically swollen ner've endings with disappearanee of vesicles were frequently found. In later stages, degenerative or neerotic cells were seattered in the aeini. and the size and the struetur'e of the remaining aeinar cells beeame gradually similar to those of non-treated glands. The morphological changes seen in the enlarged SMG induced by single amputation of the lower ineisor teeth in rat were similar in many ways to those of sialadenosis indueed experimentally by aetive sympathomitnetic drugs.

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Enlargement of rat submandibular salivary gland induced by single amputation of lower incisor teeth

Takeda

Enomoto²

1986

J Oral Pathology Medicine

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“…The significant increase when the submandibular gland weight was expressed in relation to body weight was more profound, and it was even more prominent at the later stages. This was mainly due to the fall in body weight in the rats wearing the orthodontic apparatus in contrast to the sublingual glands enlarged by this orthodontic apparatus or by an incisal bite plane , or due to periodic amputation of the lower incisor teeth (Abe et al, 1979;Wells et al, 1959;Perec et al, 1965).…”

Section: Discussionmentioning

confidence: 99%

“…Bar = 10 yiln. periodic amputation of the lower incisor teeth (Abe et aLt 1979;Abe et al, 1983;Wells et aL, 1959;Perec et a, 1965), regardless of the different experimental methods. In addition, this orthodontic appliance caused the submandibular glands to secrete additional proteins similar to those reported in the glands enlarged by chronic administration of isoproterenol (Menaker et at, 1974), in the glands enlarged by periodic amputation of the lower incisor teeth (Abe et at, 1979), and in the glands enlarged by an incisal bite plane applied to the lower incisor teeth .…”

Section: Discussionmentioning

confidence: 99%

The Effects of Upper Incisor Separation on the Submandibular and Sublingual Glands of Rats

et al. 1988

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The effects of upper incisor separation on the submandibular and sublingual glands of rats were examined biochemically, immunohistologically, and radio-immunologically during 28 days of treatment. Lateral separation of the upper incisors by application of force from an orthodontic appliance caused significant enlargement of the sublingual and submandibular glands of rats by three and seven days, respectively, after the beginning of the orthodontic treatment. This enlargement was followed by a significant increase of both RNA and DNA content, with some evidence of hyperplasia and hypertrophy. The enlargement was also associated with a significant increase of substance P at early stages after treatment, suggesting the involvement of the sensory nerves. These changes were largely inhibited by phenoxybenzamine, an alpha-adrenergic blocker, but not by atropine or morphine. Wet weights and RNA contents of the sublingual glands were markedly reduced by atropine. In comparison with control animals, the enlarged submandibular glands of rats subjected to orthodontic treatment secreted additional proteins identical with those secreted by glands enlarged by chronic administration of isoproterenol. In addition, chemical sympathectomy with 6-hydroxydopamine and phenoxybenzamine stimulated the synthesis of these abnormal proteins, but atropine and morphine did not. In contrast, protease activities in the convoluted granular tubule cells in the submandibular glands were increasingly reduced after treatment, as seen in rats subjected to chronic treatment with isoproterenol. However, the submandibular and sublingual glands completely recovered after removal of the orthodontic appliance.

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“…However, the effect of the latter was eventually more pronounced, and these results confirm those of previous studies. 17,19,30 We have assumed that the response to the IBP was mediated via increased stress to the periodontal ligaments of the incisor teeth during chewing. However, the experimental design used in this study does not rule out the possibility that the glandular responses were due to decreased stress to the periodontium of the molar teeth.…”

Section: Discussionmentioning

confidence: 99%

The Effects of an Incisal Bite Plane on Rat Sublingual Glands

Hioki¹,

Niwa²,

Kishimoto³

et al. 1983

J Dent Res

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Submaxillary and Retrolingual Gland Hypertrophy by Different Incisor Amputations in the Rat

Cited by 19 publications

References 8 publications

Enlargement of rat submandibular salivary gland induced by single amputation of lower incisor teeth

Enlargement of rat submandibular salivary gland induced by single amputation of lower incisor teeth

The Effects of Upper Incisor Separation on the Submandibular and Sublingual Glands of Rats

The Effects of an Incisal Bite Plane on Rat Sublingual Glands

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