The Effects of an Incisal Bite Plane on Rat Sublingual Glands

Hioki, S; Niwa, Katsumi; Kishimoto, Takumi; Kawazoe, Tomoya; Yokota, Yutaka; Abe, Kimio

doi:10.1177/00220345830620060501

Cited by 1 publication

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“…Chemical sympathectomy by 6-hydroxydopamine (100 mg/kg) was also performed on other groups of rats by the method of Karoum and Costa (1974), except that 6-hydroxydopamine was injected intravenously into a femoral vein on one occasion. This dose was also used in our previous reports Hioki et aL, 1983). After three days, an orthodontic device was placed in these experimental rats for seven days.…”

Section: Methodsmentioning

confidence: 99%

The Effects of Upper Incisor Separation on the Submandibular and Sublingual Glands of Rats

et al. 1988

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The effects of upper incisor separation on the submandibular and sublingual glands of rats were examined biochemically, immunohistologically, and radio-immunologically during 28 days of treatment. Lateral separation of the upper incisors by application of force from an orthodontic appliance caused significant enlargement of the sublingual and submandibular glands of rats by three and seven days, respectively, after the beginning of the orthodontic treatment. This enlargement was followed by a significant increase of both RNA and DNA content, with some evidence of hyperplasia and hypertrophy. The enlargement was also associated with a significant increase of substance P at early stages after treatment, suggesting the involvement of the sensory nerves. These changes were largely inhibited by phenoxybenzamine, an alpha-adrenergic blocker, but not by atropine or morphine. Wet weights and RNA contents of the sublingual glands were markedly reduced by atropine. In comparison with control animals, the enlarged submandibular glands of rats subjected to orthodontic treatment secreted additional proteins identical with those secreted by glands enlarged by chronic administration of isoproterenol. In addition, chemical sympathectomy with 6-hydroxydopamine and phenoxybenzamine stimulated the synthesis of these abnormal proteins, but atropine and morphine did not. In contrast, protease activities in the convoluted granular tubule cells in the submandibular glands were increasingly reduced after treatment, as seen in rats subjected to chronic treatment with isoproterenol. However, the submandibular and sublingual glands completely recovered after removal of the orthodontic appliance.

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Section: Methodsmentioning

confidence: 99%