Sublethal toxicity of quinalphos on oxidative stress and antioxidant responses in a freshwater fish <i>Cyprinus carpio</i>

Hemalatha, Devan; Amala, Antony; Rangasamy, Basuvannan; Nataraj, Bojan; Ramesh, Mathan

doi:10.1002/tox.22145

Cited by 25 publications

(3 citation statements)

References 68 publications

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“…We did not measure the neurotoxins in our study. It was considered that AChE activity had increased due to increased exposure of contaminants, which can influence the nervous system as passing through urban areas, industrial areas and sewage disposal plants [62,[71][72][73].…”

Section: Detection Of Physiological Activities Based On Acetylcholinementioning

confidence: 99%

Ecological Risk Assessment of Urban Streams Using Fish Biomarkers of DNA Damage and Physiological Responses

Bae¹,

Atique²,

Yoon³

et al. 2020

Pol. J. Environ. Stud.

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Ecological risk assessment was carried out in two urban streams, viz. Gap Stream (GS) and Miho Stream (MS), in the Geum River Watershed during July 2013-October 2014. The techniques used in this study included multi-level fish biomarkers of DNA damage based on single-cell gel electrophoresis (SCGE) coupled with the study of physiological responses based on 7-ethoxyresorufin-O-deethylase (EROD) and acetylcholinesterase (AChE) activities in fish species. Biomarker values of tail DNA (tDNA), tail length (T L), and tail extent moment (TEM) in impacted zone (I z) were 2.0-3.6-fold greater than in controls (C z). Nucleus image analysis showed that the nucleus had circular particle forms in the C z as compared with a longitudinal oval form with broken particles from the nucleus in the I z. Physiological response analysis of EROD and AchE activities indicated that their levels were higher in the I z than in the C z. Such DNA damages and greater physiological responses in the I z were attributed to chemical contaminants discharged from the wastewater disposal plants and industrial complex. This combination of DNA damage and physiological responses approach can be used as a key tool for early-warning detection of chemical contaminants and concomitant risks to the ecological health of urban streams.

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Section: Detection Of Physiological Activities Based On Acetylcholinementioning

confidence: 99%

Ecological Risk Assessment of Urban Streams Using Fish Biomarkers of DNA Damage and Physiological Responses

Bae¹,

Atique²,

Yoon³

et al. 2020

Pol. J. Environ. Stud.

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“…Our results also support the findings of extensively studied quinalphos exposed to different biological systems. For example, sub-lethal concentration of quinalphos promoted the concentration of malondialdehyde and the antioxidative systems in the liver and kidney of Cyprinus carpio (Hemalatha et al, 2016 ; Padmanabha et al, 2015 ), alteration of the pro-oxidant/ antioxidant balance in sub-cellular fractions of Mozambique tilapia gill (Ramya et al, 2015 ). Further, Ateeq et al ( 2002 ) elaborated the sequence of cellular degradation under the impact of toxicants and suggested that toxicants could cause hypoxic conditions which result in depression of ATP, leading to abnormal shape of erythrocytes.…”

Section: Resultsmentioning

confidence: 99%

Chronic exposure to quinalphos shows biochemical changes and genotoxicty in erythrocytes of silver barb, Barbonymus gonionotus

Sadiqul

Kabir

Ferdous

et al. 2017

Interdisciplinary Toxicology

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An in vivo study was carried out on the freshwater fish Barbonymus gonionotus to evaluate the genotoxic effects of the organophosphate quinalphos. The fish were exposed to sub-lethal doses of quinalphos (0%, 10%, 25%, and 50% of LC50) for a period of 30 days. Analysis of biochemical characteristics (protein and lipid contents of different organs), nuclear abnormalities of erythrocytes (NAE) and morphological abnormalities of erythrocytes (MAE) were performed on peripheral erythrocytes sampled at post-treatment intervals of 0 and 30 days. The biochemical results revealed a significant dose-dependent decline in protein and lipid contents and increase in the frequencies of NAE as well as MAE. Our findings also confirmed that the morphological deformations of erythrocytes in addition to NAE on fish erythrocytes in vivo are effective tools in determining the potential genotoxicity of organophosphates.

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“…Galar‐Martinez, Garcia‐Medina, Gomez‐Olivan, Perez‐Coyotl, Mendoza‐Monroy and Arrazola‐Morgain () reported that LPO, hydroperoxide content and protein carbonyl content levels in the liver and brain of Cyprinus carpio were increased by exposure to ketorolac. Hemalatha, Amala, Rangasamy, Nataraj and Ramesh () demonstrated that MDA levels in the liver of Cyprinus carpio were increased by exposure to quinalphos. A similar increase in MDA levels in fish liver was reported after 90 days of treatment with lindane, an organochlorine pesticide (Bainy, Arisi, Azzalis, Simizu, Barros, Videla & Junqueria ).…”

Section: Resultsmentioning

confidence: 99%

Impact of sublethal di-n-butyl phthalate on the aquaculture fish species Nile tilapia (Oreochromis niloticus ): histopathology and oxidative stress assessment

et al. 2015

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Phthalates such as di-n-butyl phthalate (DBP) and their esters are widely used plasticizers, their ubiquitous presence in daily life, inevitably leads to their restricted use due to important environmental pollution and health impacts and endocrine disruption potential. The aim of this study was to examine the effects of a sublethal concentration of 10 mg L À1 DBP on haematocrit (HCT) values, gills and liver histology, malondialdehyde (MDA, 2-thiobarbituric acid-TBA reactivity) and reduced glutathione (GSH) levels in gills and liver tissue as oxidative stress biomarkers in the aquaculture fish species Nile tilapia (Oreochromis niloticus) after 24 (DBP-24) and 96 (DBP-96) h exposure. No differences were found between per cent HCT values in the 24 h exposure groups (P > 0.05). Response of antioxidant defence systems in liver and gill tissues of the fish were dependent on exposure duration and changed to a higher extent during 96 h. MDA levels in liver tissue increased in DBP treated fish in comparison to the control fish. However, the differences between the exposure and control groups were not significant (P > 0.05). A statistically significant decrease (P > 0.05) was recorded in gill MDA levels in the DBP-96 group when compared to the control and DBP-24 groups. The liver GSH levels were unchanged in the DBP treated fish. However, GSH levels were significantly lower in the gill tissue of the DBP-96 group. Exposure to DBP caused several degenerative changes in the histology of gill and liver tissue. Gills displayed hyperaemia, epithelial lifting, oedema, talengiectasia, epithelial hyperplasia and fusion of secondary lamellae, whereas in liver several circulatory anomalies (hyperaemia, blood congestion and sinosoid dilatation) and vacuolization of hepatocytes were observed. Histopathological results demonstrated that the gills were more affected than the liver perhaps due to their direct contact with DBP.

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Sublethal toxicity of quinalphos on oxidative stress and antioxidant responses in a freshwater fish Cyprinus carpio

Cited by 25 publications

References 68 publications

Ecological Risk Assessment of Urban Streams Using Fish Biomarkers of DNA Damage and Physiological Responses

Ecological Risk Assessment of Urban Streams Using Fish Biomarkers of DNA Damage and Physiological Responses

Chronic exposure to quinalphos shows biochemical changes and genotoxicty in erythrocytes of silver barb, Barbonymus gonionotus

Impact of sublethal di-n-butyl phthalate on the aquaculture fish species Nile tilapia (Oreochromis niloticus ): histopathology and oxidative stress assessment

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