Subklinik Ketosisli Süt İneklerinde Farklı Dozlarda Butafosfan ve Siyanokobalamin Kombinasyonunun Etkisinin Değerlendirilmesi

Şahal, Mehmet; Denız, A.; Vural, Rıfat; Küplülü, Şükrü; Polat, İbrahim; Çolakoğlu, Ekrem Çağatay; Öcal, Naci; Macun, Hasan Ceyhun; Pekcan, Mert; Ocak, Marion

doi:10.9775/kvfd.2016.16651

Cited by 5 publications

(18 citation statements)

References 13 publications

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“…Indeed, when mice were fed a control diet and submitted to a caloric restriction or fed an hypercaloric diet but with no caloric restriction, butaphosphan supplementation did not affect the blood parameters, confirming that the butaphosphan effects are more evident in acute depletion of the energy status in mice. The same results were reported by other studies that have shown that the effect of butaphosphan and cyanocobalamin in increasing milk production in cattle is more pronounced when animals are in an acute state of negative energy balance, mainly in overweight animals with higher WAT reserves [32]. Our results suggest that the effects of organic phosphorous supplementation involve changes in mechanisms related to glucose homeostasis and the insulin signaling process when there is a reduction in the energy status, such as that observed in dairy cattle experiments.…”

Section: Discussionsupporting

confidence: 89%

Butaphosphan Effects on Glucose Metabolism Involve Insulin Signaling and Depends on Nutritional Plan

et al. 2020

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Butaphosphan is an organic phosphorus compound used in several species for the prevention of rapid catabolic states, however, the mechanism of action remains unclear. This study aimed at determining the effects of butaphosphan on energy metabolism of mice receiving a normal or hypercaloric diet (HCD) and submitted or not to food restriction. Two experiments were conducted: (1) during nine weeks, animals were fed with HCD (n = 28) ad libitum, and at the 10th week, were submitted to food restriction and received butaphosphan (n = 14) or saline injections (n = 14) (twice a day, for seven days) and; (2) during nine weeks, animals were fed with a control diet (n = 14) or HCD (n = 14) ad libitum, and at the 10th week, all animals were submitted to food restriction and received butaphosphan or saline injections (twice a day, for seven days). In food restriction, butaphosphan preserved epididymal white adipose tissue (WAT) mass, increased glucose, NEFA, and the HOMA index. In mice fed HCD and submitted to food restriction, the butaphosphan preserved epididymal WAT mass. Control diet influences on PI3K, GCK, and Irs1 mRNA expression. In conclusion, butaphosphan increased blood glucose and reduced fat mobilization in overweight mice submitted to caloric restriction, and these effects are influenced by diet.

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Section: Discussionsupporting

confidence: 89%

Butaphosphan Effects on Glucose Metabolism Involve Insulin Signaling and Depends on Nutritional Plan

et al. 2020

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“…A negative effect on milk production in dairy cattle associated with SCK has been reported by various authors (11,13,14,24,41,46,49,56). Cows with blood BHBA ≥ 1.4 mmol/L to 2.0 mmol/L without clinical signs in the first week postpartum had reduced milk production of between 1.4-4.2 kgs/day (13).…”

Section: Milk Production Losses Associated With Sckmentioning

confidence: 78%

“…This is due mainly to NEB in the transition period. In many cases, SCK is defined by a blood BHB concentration of ≥ 1.0 mmol/L -1.4 mmol/L (7,15,35,39,50,56,60,62). However, the most accepted threshold of blood BHBA for the definition of SCK is ≥ 1.2 mmol/L (7,35,60,62).…”

Section: Artykuł Przeglądowy Reviewmentioning

confidence: 99%

“…This elevated concentration is a result of high lipid mobilisation and consequently progressive ketogenesis in the liver (12,30). However, this silent disease is still harmful in terms of metabolic and reproductive health and milk production (11,14,32,41,49,55,56,59,62,64). This insidiously and progressive disorder causes economic losses (13,18,36,43,45), to the significant degree that it is described by some authors as a silent profit robber (9) or an underestimated profit killer (6).…”

Section: Subclinical Ketosis (Sck)mentioning

confidence: 99%

“…The risk for developing SCK is higher in multiparous than primiparous cows (7,14,27,66) and cows with SCK had reduced rumination than healthy cows (28,58), which could then be the reason for reduced DMI. SCK is defined by the absence of clinical signs and a blood BHBA concentration threshold of 0.96 mmol/L (50), 1.0 mmol/L (13,39,56,68) or the most accepted level of ≥ 1.2 mmol/L (1, 7, 14, 16, 62, 60, 64). However, there are a few studies that report a threshold of serum BHB > 1.4 mmol/L (13).…”

Section: Subclinical Ketosis (Sck)mentioning

confidence: 99%

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Transition period and subclinical ketosis in dairy cattle: association with milk production, metabolic and reproductive disorders and economic aspects

Denız¹,

Aksoy²,

Metin³

2020

Medycyna Weterynaryjna

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Many dairy cows experience a high incidence of health problems during the transition period (TP). The TP is an intermediate stage of various digestive, metabolic and reproductive functions which determine the general health status at the time of calving and during the first weeks postpartum. Negative energy balance due to increased energy demand at parturition and significantly reduced dry matter intake relative to demand is an important determinant. Consequently, substantial lipid mobilization from adipose tissue, increased oxidative stress and impaired immunity are associated with higher incidences of periparturient health problems including ketosis or subclinical ketosis (SCK), which have tremendous economic impact on dairy productivity. SCK is defined as the presence of increased blood ketone bodies (BHBA: betahydroxybutyric acid, acetone, acetoacetic acid) without clinical ketosis signs. Varying blood and milk cut-off values have been reported for BHBA concentrations defining SCK, but the most commonly accepted values are ≥ 1.2 mmol/L and ≥ 200 μmol/L respectively. This underestimated disease can impact dairy cow productivity through decreased milk production in the order of roughly 300 kg/lactation and increases the risk of metabolic and reproductive diseases such as displaced abomasum, retained placenta, metritis, mastitis, prolong oestrus interval and reduces conception rates. SCK also referred to as ‘profit robber or killer’ can cause productivity and economic losses of between $200-290 per dairy cow annually. Options for the control and prevention of SCK include controlled-release monensin capsules, and the injectable combination butaphosphan and cyanocobalamin and oral propylene glycol. SCK is easy to detect in early lactation using cow-side validated BHBA analysers with high specificity and sensitivity.

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Use of organic phosphorous butafosfan and vitamin B12 combination in transition dairy cows

Denız¹,

Aksoy²

2022

Vet. Med. - Czech

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Phosphorus is critical for life and an indispensable element for biologically occurring organic molecules such as DNA, ATP, and phosphoproteomes. Butafosfan is a synthetically produced organic phosphorous (phosphonic acid) compound that contains 17.3% phosphorus. It does not belong to the group of biologically occurring organic phosphorous compounds. Butafosfan has been used in many animal species as a metabolic stimulant interfering with energy metabolism. Vitamin B12 (VB12) is a unique cobalt-containing vitamin. It functions as a cofactor for the enzymes methionine synthase and methyl-malonyl-CoA mutase. It is necessary for the conversion of propionate into succinyl-CoA in ruminants. A combination of butafosfan and VB12 (iBC) has been available for veterinary use since 1958 and the first publication appeared in the 1970s in cows. However, the first molecular biological studies about its mode of action appeared in early 2000s. Recent studies revealed that iBC has significant effects on carbohydrate and lipid metabolism. Investigations between 1970 and 1994 focused mainly on cows at risk of metabolic and reproductive disease in the dry period. Studies as of 2000 investigated its efficacy for the prevention and treatment of subclinical and secondary ketosis, adjunctive/supportive therapy for displaced abomasum operation, milk fever, improvement of postoperative rumen activity, uterus involution, and mastitis in transition dairy cows.

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Subklinik Ketosisli Süt İneklerinde Farklı Dozlarda Butafosfan ve Siyanokobalamin Kombinasyonunun Etkisinin Değerlendirilmesi

Cited by 5 publications

References 13 publications

Butaphosphan Effects on Glucose Metabolism Involve Insulin Signaling and Depends on Nutritional Plan

Butaphosphan Effects on Glucose Metabolism Involve Insulin Signaling and Depends on Nutritional Plan

Transition period and subclinical ketosis in dairy cattle: association with milk production, metabolic and reproductive disorders and economic aspects

Use of organic phosphorous butafosfan and vitamin B12 combination in transition dairy cows

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