Subgingival microbiota in overweight and obese young adults with no destructive periodontal disease

Andrade, Danielle Rodrigues de; Silva, Paulo André; Colombo, Ana Paula Vieira; Silva-Boghossian, Carina Maciel

doi:10.1002/jper.20-0187

Cited by 18 publications

(28 citation statements)

References 40 publications

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“…These results also revealed no significant associations between clinical variables that were previously observed, such as increased prevalence in the presence of orthodontic brackets [12][13][14] and associations with higher BMI [15][16][17]. The lack of significant associations between these clinical variables and the presence of S. noxia may be due to the overall sample size of this pilot study.…”

Section: Discussioncontrasting

confidence: 60%

“…One study found that 98.4% of obese women could be identified based upon the presence of this one bacterial species (SN) in amounts greater than 1.05% of total salivary bacteria. As this organism is capable of fermenting "indigestible" carbohydrates and extracting additional calories from fiber-containing foods, this may suggest that routine screening of saliva for this organism may provide significant clinical information regarding oral and systemic health risks among dental patients in routine care [16,17].…”

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confidence: 99%

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Microbial Screening Reveals Oral Site-Specific Locations of the Periodontal Pathogen Selenomonas noxia

McDaniel

Samiano

et al. 2021

CIMB

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Introduction: Selenomonas noxia (SN) is an important periodontal pathogen, associated with gingivitis and periodontitis. Many studies have found associations between SN and indicators of poor health outcomes, such as smoking, low socioeconomic status and obesity. However, less is known about the prevalence of this organism and more specifically about other oral site-specific locations that may harbor this organism. Methods: Using an existing patient repository (n = 47) of DNA isolated from saliva and other oral sites (n = 235), including the dorsum of the tongue, lower lingual incisor, upper buccal molar and gingival crevicular fluid (GCF), molecular screening for SN was performed. Screening results were analyzed for associations between demographic variables (age, sex, race/ethnicity) and clinical information (body mass index or BMI, presence of orthodontic brackets, primary/mixed/permanent dentition). Results: qPCR screening revealed a total of n = 62/235 sites or 26.3% harboring SN with saliva and GCF (either alone or in combination with one or more sites) most often observed (Saliva, n = 23/27 or 85.18%, GCF, n = 14/27 or 51%). Analysis of site-specific data revealed most positive results were found among saliva and GCF alone or in combination, with fewer positive results observed among the tongue (33.3%), lower lingual incisor (29.6%), and upper buccal molar (25.9%). No significant associations were found between demographic or clinical variables and presence of SN at any site. Conclusions: These results may be among the first to describe site-specific locations of S. noxia among various additional oral biofilm sites. These data may represent a significant advancement in our understanding of the sites and locations that harbor this organism, which may be important for our understanding of the prevalence and distribution of these organisms among patients of different ages undergoing different types of oral treatments, such as orthodontic treatment or therapy.

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Section: Discussioncontrasting

confidence: 60%

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confidence: 99%

Microbial Screening Reveals Oral Site-Specific Locations of the Periodontal Pathogen Selenomonas noxia

McDaniel

Samiano

et al. 2021

CIMB

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“…Individuals with obesity present a constant inflammatory state; consequently, it is plausible to imagine that it impacts on the subgingival environment and influences local microbiota. Data from young adults with overweight or obesity without destructive periodontal disease demonstrated higher levels of the pathogenic species Tannerella forsythia and Porphyromonas gingivalis compared to normal-weight individuals with similar periodontal status [60]. Additional analysis of that study demonstrated that obesity parameters, such as waist circumference, hip circumference, and waist-hip ratio, had a significant positive association with P. gingivalis and Treponema denticola.…”

Section: Obesity and Periodontitis Associationmentioning

confidence: 79%

What Are the Clinical and Systemic Results of Periodontitis Treatment in Obese Individuals?

Silva-Boghossian

Dezonne

2021

Curr Oral Health Rep

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Purpose of Review Periodontitis and obesity are characterized by a dysregulated inflammatory state. Obese individuals have a higher chance of presenting periodontitis. Clinical studies in different populations demonstrate that individuals with obesity have worse periodontal conditions. This current review aims to explore recent literature to understand what the impacts of obesity on periodontal treatment outcomes are and to learn whether periodontal treatment can improve systemic biomarkers in obese individuals. Recent Findings Short- and long-term evaluations demonstrated that non-surgical periodontal treatment could improve clinical parameters in obese individuals, represented as the reduction in mean probing depth, sites with probing depth ≥ 4 mm, and extension of bleeding on probing. However, obese individuals may have less clinical improvement when compared to normal-weight individuals with a similar periodontal profile. Additionally, periodontal treatment may contribute to a reduction in systemic levels of retinol-binding protein 4 and leptin, while promoting an increase in systemic levels of adiponectin. Summary Overall, obese individuals with periodontitis can significantly benefit from non-surgical periodontal treatment. However, clinical improvements seem to be less prominent in obese individuals with periodontitis compared to non-obese individuals with similar periodontal status. Nevertheless, periodontal treatment may impact significantly on the reduction of several biochemical biomarkers of obesity with or without weight reduction. Further investigations are needed to improve our comprehension of the mechanisms underlying those findings.

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“…Thomas et al 15) conducted microbial analyses on 19 patients with periodontitis and showed that the periodontal state in obese subjects was far more deteriorated with a larger number of missing tooth and a higher score of periodontal-support loss as well as a higher level of the Capnocytophaga genus. In de Andrade et al 16) , conducted on 29 healthy, 26 overweight and 22…”

Section: Discussionmentioning

confidence: 99%

Relationship between Obesity, Gingival Inflammation, and Periodontal Bacteria after 4-Week Weight Control Program in 20’s

Seo

Hwang

2022

J Dent Hyg Sci

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Background: Obesity weakens acquired immunity and causes infection. This study aimed to investigate the relationship between the inflammatory markers in the gingival crevicular fluid and serum and periodontal bacteria in saliva through obesity control for 4 weeks. Methods: Forty-six subjects with a body mass index (BMI) of ≥23 kg/m 2 stayed in the camp for 4 weeks, followed by exercise and a low salt-low fat diet. Body size measurements, oral examinations, blood, saliva, and gingival crevicular fluid were collected before and after the program. C-reactive protein (CRP) in serum, matrix metalloproteinase (MMP)-8, MMP-9, and interleukin (IL)-1 in the gingival sulcus fluid were measured. After extracting bacterial genomic DNA from saliva, the presence of periodontal bacteria were detected using Taq probe. The relationship of each index before and after the program was analyzed through paired t-test and partial correlation analysis.Results: Campylobacter rectus (Cr) increased after the program, and there was no significant change in other bacteria. Serum CRP and Fusobacterium nucleatum (Fn), Aggregatibacter actinomycetemcomitans, Cr, ratio of Fn, and ratio of Cr had a positive relationship at baseline; however, the relationship was not significant after the program. Ratio of Prevotella intermedia had a positive relationship with MMP-9, MMP-8, IL-1 at baseline. Moreover, the ratio of Treponema denticola and the ratio of Tannerella forsythia showed a positive relationship with MMP-8, MMP-9, and IL-1. The relationship between the ratio of Porphyromonas gingivalis and IL-1 showed a constant positive relationship at baseline and after the program.Conclusion: Obesity control program in subjects with a BMI of ≥23 kg/m 2 accompanied by diet and exercise did not affect the changes in periodontal bacteria itself, but changes in the relationship between periodontal bacteria and serum CRP, the relationship between the inflammatory index in the gingival crevicular fluid and periodontal bacteria was observed.

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Subgingival microbiota in overweight and obese young adults with no destructive periodontal disease

Cited by 18 publications

References 40 publications

Microbial Screening Reveals Oral Site-Specific Locations of the Periodontal Pathogen Selenomonas noxia

Microbial Screening Reveals Oral Site-Specific Locations of the Periodontal Pathogen Selenomonas noxia

What Are the Clinical and Systemic Results of Periodontitis Treatment in Obese Individuals?

Relationship between Obesity, Gingival Inflammation, and Periodontal Bacteria after 4-Week Weight Control Program in 20’s

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