2010
DOI: 10.1590/s1678-77572010000300014
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Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats

Abstract: Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping.ObjectiveThe purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats.Material and methodsThe materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrif… Show more

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Cited by 12 publications
(15 citation statements)
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“…Lymphocytes were considered the cells with small, round, and hyperchromatic nuclei, revealing a lack of cytoplasm. By contrast, the macrophages presented ample, hyperchromatic, and oval or bean-shaped nuclei, with a greater quantity of cytoplasm [13].…”
Section: Methodsmentioning
confidence: 82%
“…Lymphocytes were considered the cells with small, round, and hyperchromatic nuclei, revealing a lack of cytoplasm. By contrast, the macrophages presented ample, hyperchromatic, and oval or bean-shaped nuclei, with a greater quantity of cytoplasm [13].…”
Section: Methodsmentioning
confidence: 82%
“…Some studies (CHANG et al, 1998;CAMARGO et al, 2009;SEPET et al, 2009;SILVA et al, 2012A;SILVA et al, 2012B;YOSHINO et al, 2013) used fibroblasts for quick and easy growth (HIRSHMAN et al, 2012), in addition to their availability in periapical tissues and the periodontal ligament, which are areas that are susceptible to the effects of intracanal medications and their degradation products (YOSHINO et al, 2013). Fibroblasts are also the largest producers of collagen tissue and, therefore, actively participate in the repair tissue process (SILVA et al, 2012B).…”
Section: Discussionmentioning
confidence: 99%
“…The rationale for the observed cytotoxicity may be the extremely alkaline environment, which promotes enzymatic denaturation and destruction of the cell membrane, leading to cell death (GUIGAND et al, 1999;SEPET et al, 2009;SILVA et al, 2012B). In animals, this cytotoxic action occurs when calcium hydroxide comes in direct contact with subcutaneous tissue, inducing inflammatory reactions of moderate to severe intensity and resulting in protein denaturation in the cells, especially of neutrophils, and areas of necrosis and dystrophic calcification (NELSON FILHO et al, 1999;CAMARGO et al, 2010;TOMAZ et al, 2013).…”
Section: Discussionmentioning
confidence: 99%
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