Subcutaneous extraskeletal osteosarcoma in a metatarsal footpad in a cat

Almela, Ramón; Bomhard, Wolf von; Ansón, Agustina; Mayer, Ursula

doi:10.1111/vde.12461

Cited by 8 publications

(14 citation statements)

References 11 publications

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“…In addition, there is limited data on histological classification or classification system for osteosarcomas in cats unlike in dogs (1). Also, there is a significant relationship between the mitotic index and survival (8)(9)(10)(11), however, we did not find any mitotic figures in the tumoral mass in our study. In addition to mitotic figures, the presence of multicore bizarre giant cells was not found as described in previous studies (8,9,12).…”

Section: Discussioncontrasting

confidence: 65%

“…2,[7][8][9][10] Other forms of trauma have also been linked to osteosarcoma development in soft tissues. Extraskeletal osteosarcomas have been reported in the eye secondary to ocular trauma, 18,19 the duodenum secondary to a foreign body reaction, 20 the mammary gland, 21 metatarsal foot pad, 22 muscle tissue 23 and at vaccination sites. 24 Trauma was thought to play a role in the development of osteosarcoma in these cases.…”

Section: Discussionmentioning

confidence: 99%

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Late-onset osteosarcoma after onychectomy in a cat

Breitreiter¹

2019

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 12-year-old neutered male onychectomized Ragdoll cat presented for a 3 day history of swelling and hemorrhagic purulent discharge on the first digit of the left manus. Radiographs revealed fragments of the third phalangeal bone (P3) present in the partially amputated digits with swelling adjacent to the P3 fragment on the first digit of the left manus. Thoracic radiographs revealed no evidence of primary or metastatic neoplasia. Surgery was performed to remove all P3 fragments and the associated swelling on the diseased digit. On gross examination of the excised swelling, a mass was present at the cut edge of P3. The bone fragment and associated mass were submitted for histopathological evaluation. Osteosarcoma was diagnosed. Because neoplastic cells extended to the surgical margins, amputation of the left thoracic limb was performed. The cat recovered from surgery, and survival time at the time of writing was 8 months. Relevance and novel information To our knowledge, this is the first reported case of onychectomy-associated osteosarcoma. Trauma from partial P3 amputation during onychectomy is suspected to have played a role in osteosarcoma development in this case. Malignant transformation may be considered a potential complication of onychectomy achieved by partial P3 amputation.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Late-onset osteosarcoma after onychectomy in a cat

Breitreiter¹

2019

Journal of Feline Medicine and Surgery Open Reports

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“…Osteosarcoma (OS) is the most common type of primary malignant bone tumor among adolescents 1,2 . As the most common malignant tumor of bone, approximately 80%–90% of patients have a relatively poor prognosis 3 . Before the 1970s, amputation was the main treatment for OS 4 .…”

Section: Introductionmentioning

confidence: 99%

miR‐874‐3p inhibits cell migration through targeting RGS4 in osteosarcoma

Liu

Zhuo

Lü

et al. 2020

The Journal of Gene Medicine

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Background The present study explored the role and mechanism of microRNA‐874‐3p (miR‐874‐3p) in the migration of the osteosarcoma cell line, U‐2 OS. Methods The expression profile of osteosarcoma (OS) microRNA (GSE65071) datasets was downloaded from the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo) to identify differentially expressed miRNAs in OS and its biological functions. A quantitative reverse transcription‐polymerase chain reaction was performed to detect the expression of miR‐874‐3p and its target gene regulator of G protein 4 (RGS4) in human osteosarcoma cells U‐2 OS and normal osteoblast hFOB1.19. Plasmid overexpression miR‐874‐3p and pcDNA‐RGS4 were transfected into U‐2 OS using Lipofectamine 2000 (Thermo Fisher, Waltham, MA, USA). Cell migration was measured using Transwell migration assays. Bioinformatic analysis and luciferase reporter assay were conducted to search for the target gene of miR‐874‐3p. Results In total, 167 differentially expressed miRNAs were detected after the analysis of GSE65071; of which 78 were up‐regulated genes and 89 were down‐regulated. miR‐874‐3p was down‐regulated and selected for further analysis. The expression level of miR‐874‐3p in U‐2 OS cells was significantly decreased compared to the hFOB1.19 cell line (p < 0.05). Overexpression of miR‐874‐3p significantly inhibited the proliferation and migration of U‐2 OS cells and overexpression of RGS4 reversed the inhibitory effect of miR‐874‐3p on U‐2 OS cells. Through luciferase report analyses and bioinformatic analysis, RGS4 may be the candidate target gene of miR‐874‐3p. Conclusions In conclusion, overexpression of miR‐874‐3p suppressed OS cell proliferation and migration. Thus, miR‐874‐3p might present a therapeutic agent for the treatment of OS.

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“…The histologic appearance of osteosarcomas varies, but is characterized by neoplastic cell production of osteoid and/or osseous tissues. 1,2,5 Osteosarcomas have been further divided into different morphological subtypes, including osteoblastic, fibroblastic, chondroblastic, telangiectatic and mixed cell types. 1,2 In the present case, the neoplastic cells produced osteoid and osseous tissues with large zones of prominent cartilaginous differentiation characterized by production of cartilage matrix/ cartilage tissue with extracellular accumulation of collagen and mucoid-appearing, Alcian blue-staining extracellular material (most likely chondroitin, some other unidentified or mixed matrix).…”

Section: Discussionmentioning

confidence: 99%

“…This neoplasm has been reported in a variety of animals. 1,2 Feline extraskeletal osteosarcoma has been described in the subcutaneous tissue, [3][4][5] eyes, 3,6 liver, 7 oral cavity, 3 intestines/omentus 8 and in the mammary region. 3 Of the reported subtypes, the extraskeletal chondroblastic osteosarcoma is reported to be very rare.…”

Section: Introductionmentioning

confidence: 99%

Subcutaneous extraskeletal chondroblastic osteosarcoma in a cat

Verdes

Cecilia

Yamasaki

2019

Journal of Feline Medicine and Surgery Open Reports

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Case summary An 11-year-old neutered male cat was presented with a fixed, subcutaneous mass in the left hindlimb. The neoplasm was surgically removed and determined to be a 2 × 2 × 9 cm mass that extended over the plantar surface of the left hindlimb from the tarsus to the phalanges. It was independent from the skeletal system but firmly attached to the adjacent connective tissue. Microscopically, the neoplasm was composed of highly proliferative mesenchymal neoplastic cells that formed both osseous and cartilaginous tissues with associated production of chondroid, osteoid and associated matrixes. This neoplasia was diagnosed as an extraskeletal chondroblastic osteosarcoma. Extraskeletal osteosarcomas, especially the chondroblastic subtype, are extremely rare in cats. Consequently, little is known concerning their course and prognosis. In this case, excision with wide margins appeared to be successful as, at the time of writing, 24 months after limbectomy, the cat is healthy with no evidence of recurrence or metastasis. Relevance and novel information To our knowledge, this is the first report of an appendicular large extraskeletal chondroblastic osteosarcoma occurring in a domestic cat. As these neoplasms are rare, it should be considered as a less likely cause of soft tissue appendicular neoplasms in domestic cats.

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Subcutaneous extraskeletal osteosarcoma in a metatarsal footpad in a cat

Abstract: Extraskeletal osteosarcoma should be considered in the differential diagnosis of soft tissue swelling in footpads in cats. Advanced diagnostic imaging is recommended to exclude primary bone tumours.

Cited by 8 publications

References 11 publications

Late-onset osteosarcoma after onychectomy in a cat

Late-onset osteosarcoma after onychectomy in a cat

miR‐874‐3p inhibits cell migration through targeting RGS4 in osteosarcoma

Subcutaneous extraskeletal chondroblastic osteosarcoma in a cat

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