Subclinical hypothyroidism is associated with albuminuria in Japanese nondiabetic subjects

Toda, Akiko; Tsuji, Hiroshi; Arase, Yasuji

doi:10.1007/s12020-020-02220-9

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…In our study we found a positive association between serum fT4 levels and albuminuria, but no such association for TSH or fT3. The literature showed associations of subclinical hypothyroidism [9] or low fT3 levels [10] with albuminuria, which is in contrast to our findings. The difference in results might be related to different ethnicities, because the two latter studies were both conducted in Asian populations [9,10].…”

Section: Discussioncontrasting

confidence: 99%

“…The literature showed associations of subclinical hypothyroidism [9] or low fT3 levels [10] with albuminuria, which is in contrast to our findings. The difference in results might be related to different ethnicities, because the two latter studies were both conducted in Asian populations [9,10]. Furthermore, one of those studies was conducted in health-check-up individuals [9], which may represent only a relatively healthy snapshot of the general Japanese population.…”

Section: Discussioncontrasting

confidence: 99%

“…The difference in results might be related to different ethnicities, because the two latter studies were both conducted in Asian populations [9,10]. Furthermore, one of those studies was conducted in health-check-up individuals [9], which may represent only a relatively healthy snapshot of the general Japanese population. In the other study, results were only reported for fT3 but not for TSH or fT4 [10].…”

Section: Discussionmentioning

confidence: 99%

“…To date, there is limited knowledge of the association between thyroid function and albuminuria. In a large Japanese population of individuals, who underwent a health check-up, subclinical hypothyroidism was associated with albuminuria defined as a urinary albumin-creatinine ratio (UACR) ≥30 mg/g [9]. In a population-based study from China, free triiodothyronine (fT3) levels in serum were inversely associated with a UACR between 30 and 300 mg/g but there were no results reported for TSH or free thyroxine (fT4) levels [10].…”

Section: Introductionmentioning

confidence: 99%

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High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany

Ittermann,

von Rheinbaben,

Markus

et al. 2023

JCM

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High serum thyroid-stimulating hormone (TSH) levels have previously been associated with a low estimated glomerular filtration rate (eGFR), but studies associating thyroid hormone levels with albuminuria revealed inconsistent results. We used cross-sectional data from 7933 individuals aged 20 to 93 years of the Berlin Aging Study II and the Study of Health in Pomerania to associate serum TSH, fT3, and fT4 levels with eGFR and albuminuria. In multivariable analyses adjusted for confounding, we found inverse non-linear associations of serum TSH levels with eGFR, while serum fT3 levels showed a positive association with eGFR. High as well as low serum fT4 levels were associated with a lower eGFR. Age but not sex modified the association between thyroid hormone levels and eGFR. The inverse associations between serum TSH levels and eGFR were strongest in the youngest age groups, while the positive associations between serum fT3 levels and eGFR were strongest in older individuals. No significant associations between thyroid hormone levels and albuminuria were found. Our results indicate that hypothyroidism might be associated with a reduced kidney function. Thyroid function might be more tightly related to the eGFR than to albuminuria in the general population.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany

Ittermann,

von Rheinbaben,

Markus

et al. 2023

JCM

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“…The clinical presentation of the children with SH may vary from no clinical symptoms to a clear picture of thyroid impairment 5 . Recent studies in adult populations showed that SH is associated with increased cardiovascular risk, albuminuria, elevation in total cholesterol and low‐density lipoprotein, systemic hypothyroid symptoms or neuropsychiatric symptoms (eg, depression and negativism) 3,6‐8 . Unfortunately, there are a few studies including children with SH 9‐13 .…”

Section: Introductionmentioning

confidence: 99%

The effect of subclinical hypothyroidism on body composition parameters in children

2020

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Background It's known that overt hypothyroidism increases body fat content and weight. There's limited research about the effect of subclinical hypothyroidism (SH) on body composition in children and the effect of LT4 treatment. We aimed to evaluate body composition parameters in healthy subjects and in children with mild SH (MSH) and determine the effect of LT4 treatment. Methods Sixty‐four healthy children and 32 children with MSH were included. Anthropometric measurements and hormonal parameters were evaluated. Body composition was evaluated using bioelectric impedance analysis (BIA). Patients were put on LT4 treatment. BIA was performed again after 12 months of therapy. Results There was no significant difference between the anthropometric parameters and basal metabolic rate of the healthy children and the MSH group. The percentage of trunk muscle mass (TMM) in the MSH group was lower than in the control group (P < .05). After 12 months of LT4 treatment, the percentage of total fat‐free mass (FFM), TMM and trunk fat‐free mass (TFFM) were increased and percentage of total body fat mass and trunk fat mass were decreased (P < .05). The difference between the percentage of TMM in the MSH group and control group was insignificant after LT4 treatment (P > .05). Conclusions The percentage of TMM in children with MSH was found lower than healthy control group. After LT4 treatment, the percentage of the FFM, TMM and TFFM were increased and the difference between percentage of TMM in children with MSH and healthy controls was insignificant. Our data indicated that MSH might be associated with early changes in body composition parameters.

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Impaired sensitivity to thyroid hormones is associated with albuminuria in the euthyroid population: results from NHANES

Wang,

Wu,

Pan

et al. 2024

Hormones

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Subclinical hypothyroidism is associated with albuminuria in Japanese nondiabetic subjects

Cited by 5 publications

References 30 publications

High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany

High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany

The effect of subclinical hypothyroidism on body composition parameters in children

Impaired sensitivity to thyroid hormones is associated with albuminuria in the euthyroid population: results from NHANES

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