Subcellular and Intercellular Aspects of Tuberculous Infection in Reference to Protection and Sensitization

Kanai, Koomi; Kondo, Eiko

doi:10.7883/yoken1952.25.133

Cited by 5 publications

(2 citation statements)

References 112 publications

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“…the case, intracellular proteases (cathepsins) may be responsible for the degradation. Cathepsins are lysosomal hydrolases; the lysosome-tubercle bacillus interaction within macrophages is an important factor in the development of tuberculous infection (Armstrong and D'Arcy Hart, 1971;Kanai and Kondo, 1972). These considerations.…”

Section: Introductionmentioning

confidence: 99%

Degradation of Tuberculoproteins by Incubation With Lysosomal Components of the Mouse Spleen

Kanai¹,

Kondo

1972

JJMSB

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Section: Introductionmentioning

confidence: 99%

Degradation of Tuberculoproteins by Incubation With Lysosomal Components of the Mouse Spleen

Kanai¹,

Kondo

1972

JJMSB

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“…Scientific literature contains strong evidence that macrophages participate in the acquired resistance to intracellular pathogenic microorganisms (19) and tumor cells (12). Investigations into the nature of the molecules responsible for the expression of macrophage-mediated resistance have suggested that lipoidal materials, especially free fatty acids, may play a significant role in it (10,14,16,18,24).…”

mentioning

confidence: 99%

Secretion of Antimycobacterial Fatty Acids by Normal and Activated Macrophages

Hemsworth

Kochan

1978

Infect Immun

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Cellular resistance to facultative intracellular parasites has been studied by determining the antimycobacterial activity and the amount of fatty acids in sera and in heptane extracts of freshly collected and 24-h-cultured normal and activated guinea pig alveolar macrophages and liver cells. The quantity and the antimycobacterial activity of extractable fatty acids were determined by gas chromatography and the agar plate diffusion test, respectively. These determinations showed that heptane extracts of activated cells inhibited the growth of BCG much more effectively than fractions prepared from normal cells; chromatographic analyses showed that extracts of activated cells contained six times more C16 and C18 long-chain fatty acids than did fractions of normal cells. Heptane extracts of 24-h-cultured cells and of their media showed that during incubation normal and activated cells release fatty acids into the culture media without apparent cell injury; in all experiments liver cells produced larger amounts of fatty acids than alveolar macrophages. Sera collected from activated guinea pigs inhibited the growth of BCG and contained two to five times more total fatty acids than did the growth-supporting normal serum. That bactericidal fatty acids are excreted into the tissue culture medium of incubated cells or into the blood of immunologically stimulated animals suggests that macrophages can exert antibacterial effects without phagocytosis.

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Delayed Hypersensitivity in the Mouse

Crowle

1975

Advances in Immunology

183

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Subcellular and Intercellular Aspects of Tuberculous Infection in Reference to Protection and Sensitization

Cited by 5 publications

References 112 publications

Degradation of Tuberculoproteins by Incubation With Lysosomal Components of the Mouse Spleen

Degradation of Tuberculoproteins by Incubation With Lysosomal Components of the Mouse Spleen

Secretion of Antimycobacterial Fatty Acids by Normal and Activated Macrophages

Delayed Hypersensitivity in the Mouse

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