Delayed Hypersensitivity in the Mouse

Crowle, Alfred J.

doi:10.1016/s0065-2776(08)60209-6

Cited by 183 publications

(91 citation statements)

References 153 publications

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“…This is followed by a dramatic influx of mononuclear cells, such that by 24 -48 h the lesion is mostly mononuclear with a mix of T cells and macrophages (73). Paradoxically, in mice where the peripheral blood has a relative paucity of neutrophils compared with humans, the DTH response tends to be more neutrophil rich (74). In addition, elicitation of murine DTH requires much higher concentrations of Ag than in humans.…”

Section: Differences In Immune System Biologymentioning

confidence: 99%

Of Mice and Not Men: Differences between Mouse and Human Immunology

Mestas

Hughes

2004

The Journal of Immunology

2,985

2,322

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Mice are the experimental tool of choice for the majority of immunologists and the study of their immune responses has yielded tremendous insight into the workings of the human immune system. However, as 65 million years of evolution might suggest, there are significant differences. Here we outline known discrepancies in both innate and adaptive immunity, including: balance of leukocyte subsets, defensins, Toll receptors, inducible NO synthase, the NK inhibitory receptor families Ly49 and KIR, FcR, Ig subsets, the B cell (BLNK, Btk, and λ5) and T cell (ZAP70 and common γ-chain) signaling pathway components, Thy-1, γδ T cells, cytokines and cytokine receptors, Th1/Th2 differentiation, costimulatory molecule expression and function, Ag-presenting function of endothelial cells, and chemokine and chemokine receptor expression. We also provide examples, such as multiple sclerosis and delayed-type hypersensitivity, where complex multicomponent processes differ. Such differences should be taken into account when using mice as preclinical models of human disease.

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Section: Differences In Immune System Biologymentioning

confidence: 99%

Of Mice and Not Men: Differences between Mouse and Human Immunology

Mestas

Hughes

2004

The Journal of Immunology

2,985

2,322

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“…Unexpectedly, however, DTHeffector cells derived from immune donors exposed to Cd were intact and able to elicit DTH, upon transfer, in normal recipient mice (Table II). Thus, another probable target for Cd may be monocyte known to be involved in the expression of DTH (Crowle, 1975). Another significant aspect of this study was that the immunosuppression by a single exposure to Cd was related to the time intervals between Cd treatment and antigenic stimulation.…”

Section: Discussionmentioning

confidence: 80%

Acute Effects of Cadmium on Delayed-Type Hypersensitivity in Mice

Kojima

Tamura

1981

JJMSB

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SUMMARY: A single exposure of mice to cadmium resulted in suppression of the induction of primary delayed-type hypersensitivity (DTH) responses as well as memory T-cell and suppressor T-cell activities, augmenting and inhibiting DTH respectively. Furthermore, cadmium suppressed the expression of already established DTH, in immune mice, even though DTH-effector T cells in the spleen of immune mice were not affected by cadmium injeciton. Such suppressive effects were demonstrated when cadmium was administered within 2 days before immuniza tion or elicitation for DTH. Cadmium caused also within 2 days in mice thymic involution and splenomegaly.These results indicate that cadmium inhibits not only the generation of certain populations of T lymphocytes for DTH but also some mechanisms in the host involved in the expression of DTH.

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“…From these results it is more likely that the present immunological memory is T cellassociated. T cells are know to be responsible for DH and the level of DH depends on many factors such as nature of antigen, dose, route, vehicle of administration, and the method for estimating DH (2). The present experiments were designed to establish the conditions for induction of DH by an extensively modified BaA derivative in relation to the development of immunological memory.…”

Section: Discussionmentioning

confidence: 99%