Subacute thyroiditis in psoriatic arthritis treated by adalimumab

Senlis, Marion; Ottaviani, Sébastien; Gardette, Anaïs; Palazzo, Élisabeth; Coustet, Baptiste; Dieudé, Philippe

doi:10.1016/j.jbspin.2016.09.015

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…reported a patient with palmoplantar psoriasis, who was treated with adalimumab, 40 mg twice monthly, and developed SAT several months later. Senlis et al . also described SAT in a patient with PsA after adalimumab treatment, 40 mg every other week for 10 months.…”

Section: Discussionmentioning

confidence: 94%

Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor‐α inhibitor

2018

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CaseA 41-year-old woman has a 26-year history of psoriasis vulgaris and psoriatic arthritis (PsA). Initially, multiple erythematous to brownish thick scaly plaques and papules were observed over her limbs (Fig. 1). Subsequently, arthralgia developed bilaterally over the knees and progressed to the hands and feet. X-ray films revealed subluxation and deformity of the small hand joints (Fig. 2). Her past medical history was otherwise unremarkable.She received topical steroid, calcipotriol, and broadband ultraviolet B therapy, but the disease persisted with intermittent flare-ups. Methotrexate was prescribed, but active arthritis over the hands, elbows, and right ankle were persistent, hence rheumatologists switched to leflunomide for PsA treatment. Nevertheless, the progression of joint deformities and swelling continued. She was subsequently shifted to adalimumab subcutaneous injection (40 mg every other week).However, she experienced an intermittent cough for 7 months after adalimumab initiation. Three weeks after discontinuation of adalimumab, episodic fever up to 38°C with an intermittent sore throat occurred for 1 week. Subsequently, the symptoms worsened with anterior neck tenderness, low-grade fever, and submandibular lymphadenopathy in the next week.Restless hand tremors and palpitations were also observed.Laboratory data showed thyroid-stimulating hormone (TSH), 0.006 mU/l; T 3 , 3.9 nmol/l; T 4 , >308.9 nmol/l; free T 4 , 52.6 pmol/l; and erythrocyte sedimentation rate, 89 mm/h. The results of a serology survey for influenza infection were Figure 1 Multiple erythematous to brownish thick scaly plaques and papules over the patient's upper limbs ª

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Section: Discussionmentioning

confidence: 94%

Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor‐α inhibitor

2018

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“…Some studies showed that anti-TNF agents are associated with improved autoimmune thyroid diseases and reduced thyroglobulin and thyroid peroxidase antibody concentrations (3). Data on the association between anti-TNF agents and subacute thyroiditis is scarce as case reports (4)(5)(6)(7)(8)(9)(10)(11)(12). A summary of the reported cases is given in Table 2.…”

Section: Discussionmentioning

confidence: 99%

“…The authors suggested that the underlying amyloid goiter might have contributed to developing signs and symptoms. Two more cases of subacute thyroiditis were reported with adalimumab therapy for psoriasis and psoriatic arthritis (10,11). The typical laboratory findings of subacute thyroiditis are suppressed thyroid-stimulating hormone (TSH), elevated CRP, and erythrocyte sedimentation rate (ESR).…”

Section: Discussionmentioning

confidence: 99%

Subacute thyroiditis associated with adalimumab - a case report and review of the literature

Kuşkonmaz¹,

Koç²,

Özenmiş³

et al. 2022

Northwestern Med J

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Subacute thyroiditis is characterized by the painful inflammation of the thyroid and thyrotoxicosis due to thyroid destruction. A few case reports looked into the association between anti-tumor necrosis factor (anti-TNF) agents and subacute thyroiditis. A 42-year-old woman was admitted to the hospital for fever and neck pain spreading to the right ear. For the last seven years, she has been on adalimumab treatment (40 mg every 15 days) for ankylosing spondylitis. Thyroid scintigraphy showed a diffusely suppressed gland which confirmed the diagnosis of subacute thyroiditis. Adalimumab treatment was stopped, and methylprednisolone 32 mg/day was started. Adalimumab use may be associated with subacute thyroiditis.

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“…2 To date, four cases of SAT during anti-tumor necrosis factor (TNF) treatment for psoriasis were reported (Table 1). [3][4][5][6] Most authors inferred that TNF inhibitors induced an immunosuppressive status and rendered patients susceptible to viral infection. As for IL-17, recent studies indicate its involvement in thyroid disorders.…”

Section: Casementioning

confidence: 99%

Subacute thyroiditis in psoriasis patients treated with biologics targeting tumor necrosis factor‐α and interleukin‐17A, a report of two cases

Nakamura

Kamata

Sato

et al. 2020

J Cutaneous Imm & Allergy

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Subacute thyroiditis in psoriatic arthritis treated by adalimumab

Cited by 7 publications

References 9 publications

Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor‐α inhibitor

Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor‐α inhibitor

Subacute thyroiditis associated with adalimumab - a case report and review of the literature

Subacute thyroiditis in psoriasis patients treated with biologics targeting tumor necrosis factor‐α and interleukin‐17A, a report of two cases

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