1984
DOI: 10.1001/archderm.120.3.332
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Abstract: Subacute cutaneous lupus erythematosus (SCLE) is a recently described distinct subset of lupus erythematosus (LE) having characteristic clinical, serologic, and genetic findings. This study describes the histopathologic characteristics of SCLE and determines whether it could be differentiated from discoid lupus erythematosus (DLE) on histopathologic grounds alone. Biopsy specimens from 33 patients having either SCLE or DLE, as defined by strict clinical criteria, were examined without knowledge of the clinical… Show more

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Cited by 72 publications
(43 citation statements)
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“…45,46 Histological evaluation of skin lesions is necessary to confirm the diagnosis of LET, and, therefore, it represents one of the major criteria of this disease (Table 3). In contrast to SCLE and DLE, 30,32,33,47 follicular hyperkeratosis, epidermal atrophy, vacuolar degeneration, and thickening of the basement membrane zone usually are not found. The perivascular and periadnexal infiltrate is composed of lymphocytes and, in some cases, scattered neutrophils are seen.…”
Section: Commentmentioning
confidence: 86%
“…45,46 Histological evaluation of skin lesions is necessary to confirm the diagnosis of LET, and, therefore, it represents one of the major criteria of this disease (Table 3). In contrast to SCLE and DLE, 30,32,33,47 follicular hyperkeratosis, epidermal atrophy, vacuolar degeneration, and thickening of the basement membrane zone usually are not found. The perivascular and periadnexal infiltrate is composed of lymphocytes and, in some cases, scattered neutrophils are seen.…”
Section: Commentmentioning
confidence: 86%
“…In contrast to LET, the clinical hallmark of DLE is a discoid plaque with scarring, atrophy, and follicular plugging. In patients with SCLE, erythematous papulosquamous or annular skin lesions in sun-exposed areas can also be seen, but results of histologic examination differ from LET, demonstrating a focally thinned epidermis with vacuolar degeneration at the dermoepidermal junction [28, 29]. Furthermore, early lesions of polymorphous light eruption may be difficult to differentiate from LET; however, in contrast to LET, they occur several hours after UV irradiation, and, in most cases, polymorphous light eruption shows no improvement with antimalarial drug therapy [18, 30, 31].…”
Section: Discussionmentioning
confidence: 99%
“…Bangert et al, 17 stated that the presence of hyperkeratosis, thickening of the basal membrane, extensive follicular damage and dense lymphocyte infiltrate involving the deep dermis are findings that favor a diagnosis of DLE. The changes found in SCLE are quantitatively different from those found in DLE, and epidermal atrophy is an important characteristic.…”
Section: Sontheimermentioning
confidence: 99%