Lupus erythematosus tumidus in Childhood

Sonntag, Monika; Lehmann, Percy; Megahed, Mosaad; Ruzicka, Thomas; Kuhn, Annegret

doi:10.1159/000071793

Cited by 37 publications

(26 citation statements)

References 20 publications

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“…an inflammatory infiltrate at the epidermal-dermal junction, with vacuolization of basal keratinocytes and some degree of epidermal necrosis. We now need to expand these specific lesions to include the entirely dermal variants of LE, namely lupus tumidus (LT) [25, 28, 29] and probably JLI. In our opinion, these two entities are highly overlapping, both clinically and pathologically.…”

Section: Discussionmentioning

confidence: 99%

Could Jessner’s Lymphocytic Infiltrate of the Skin Be a Dermal Variant of Lupus Erythematosus? An Analysis of 210 Cases

et al. 2006

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Background and Objective: The objective of this study was to evaluate the relationship between Jessner’s lymphocytic infiltration of the skin (JLI) and lupus erythematosus (LE), which has been the subject of debate since its initial description in 1953. Material and Methods: This is a retrospective study including all patients with a histopathologically ascertained diagnosis of JLI performed at the Laboratoire d’Histopathologie Cutanée of the Strasbourg University Hospital between 1993 and 2003. Information about patient characteristics and follow-up data were retrieved between 2004 and 2005. Special attention was paid to features indicative of LE. Results: 210 consecutive patients (102 women and 108 men) with a mean age 42 years were diagnosed with JLI in the reference period. 175 patients (83%) had multiple lesions and 32 patients (15%) had only a single lesion at the time of diagnosis (data not available in 3 patients). The head, neck and upper part of the thorax were involved in 171 patients (81%). An annular or arciform configuration and/or arrangement were present in 111 patients (53%). Lesions consisted of red (100%) papules or plaques (98%). Mean follow-up was 4 years. Sixteen patients (7.6%) had proven LE. Only 2 patients (1%) developed >4 ACR criteria of systemic LE. Furthermore, 1 patient had antiphospholipid antibody syndrome and 2 patients had rheumatoid arthritis. Conclusions: This high frequency of patients with typical features of LE strongly argues that JLI could be a dermal variant of LE and not an autonomous entity. It might be the cutaneous marker of a subset of LE patients with excellent prognosis.

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Section: Discussionmentioning

confidence: 99%

Could Jessner’s Lymphocytic Infiltrate of the Skin Be a Dermal Variant of Lupus Erythematosus? An Analysis of 210 Cases

et al. 2006

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“…Incidence of LET among women and men is approximately same [2]. The disease usually presents in the 30-40`s age range, but several cases have been reported in kids [3].…”

Section: Discussionmentioning

confidence: 99%

Lupus Tumidus: underreported variant of lupus erythematosus (a case report and review of the literature)

Kazlouskaya¹,

Lal²,

Khaikova³

2014

Our Dermatol Online

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Introduction: Lupus erythematosus tumidus (LET) is an underreported variant of lupus erythematosus (LE) that is characterized by soft urticarial-like elements usually located on the sun exposed skin. LET is featured with high photosensitivity. Lesions of LET resolve without scarring and do not cause disfigurement as seen in the discoid LE variants. Lesions of LET may co-exist with other variants of LE: discoid or systemic.Main observations: The case presents a female patient with LET localized on the lateral infraorbital areas of her face and cheeks. Histopathological evaluation showed a lymphocytic infiltrate in the middle and deeper parts of the dermis. This article also presents a contemporary review of the clinical variants of LET, histopathological features and approaches to the treatment of LET. Conclusions: LET should be considered in urticarial-like lesions on the skin of the face and other skin exposed areas. Histopathological examination is needed to make a definitive diagnosis of the condition and helps in cases when the clinical presentation is subtle or nonspecific.

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“…22 Histopathologically they show perivascular and periadnexal lymphohistiocytic infiltrate in the papillary and reticular dermis and intersti- tial mucin deposition. 21,23 Epidermal atrophy and changes in the dermal-epidermal junction are absent. 24 In lupus panniculitis (lupus profundus) the face, neck, shoulders and arms, and possibly hips and gluteal regions are affected.…”

Section: Sontheimermentioning

confidence: 99%

Lúpus eritematoso cutâneo: aspectos clínicos e laboratoriais

Berbert

Mantese

2005

An. Bras. Dermatol.

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Lupus erythematosus is a connective tissue autoimmune disorder that demonstrates systemic, cutaneous, or both systemic and cutaneous manifestations. Cutaneous lesions are classified as specific and nonspecific. The variety of clinical manifestations of the disease is reflected in the broad spectrum of laboratory patterns. In this article we describe the distinct subsets of cutaneous lupus erythematosus, correlating them with histopathological, direct immunofluorescence and serological findings. Keywords: Skin diseases; Autoimmune diseases; Collagen diseases; Connective tissue diseases; Lupus erythematosus, Cutaneous/classification; Lupus erythematosus, Cutaneous/diagnosis. Resumo: O lúpus eritematoso é doença auto-imune do tecido conjuntivo que reúne manifestações exclusivamente cutâneas ou multissistêmicas, podendo apresentar exuberância de auto-anticorpos. As lesões cutâneas do lúpus eritematoso são polimorfas e podem ser específicas ou inespecíficas. A diversidade de manifestações clínicas da doença reflete-se no amplo espectro de achados laboratoriais. Este artigo descreve as variadas formas clínicas do lúpus eritematoso cutâneo correlacionan

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Lupus erythematosus tumidus in Childhood

Cited by 37 publications

References 20 publications

Could Jessner’s Lymphocytic Infiltrate of the Skin Be a Dermal Variant of Lupus Erythematosus? An Analysis of 210 Cases

Could Jessner’s Lymphocytic Infiltrate of the Skin Be a Dermal Variant of Lupus Erythematosus? An Analysis of 210 Cases

Lupus Tumidus: underreported variant of lupus erythematosus (a case report and review of the literature)

Lúpus eritematoso cutâneo: aspectos clínicos e laboratoriais

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