Lupus Erythematosus Tumidus

Kuhn, Annegret; Richter-Hintz, Dagmar; Oslislo, Claudia; Ruzicka, Thomas; Megahed, Mosaad; Lehmann, Percy

doi:10.1001/archderm.136.8.1033

Cited by 211 publications

(94 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Why? Because many authors argued that JLI is an autonomous entity [17,18,19,20,21,22,23,24,25], some even suggesting differentiating features between the two diseases, which are summarized in table 3. The findings reported as specific in most of these studies, as for example the diagnostic value of plasmacytoid monocytes in the infiltrate of patients with JLI, were subsequently not confirmed in other studies [26].…”

Section: Discussionmentioning

confidence: 99%

“…an inflammatory infiltrate at the epidermal-dermal junction, with vacuolization of basal keratinocytes and some degree of epidermal necrosis. We now need to expand these specific lesions to include the entirely dermal variants of LE, namely lupus tumidus (LT) [25, 28, 29] and probably JLI. In our opinion, these two entities are highly overlapping, both clinically and pathologically.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Could Jessner’s Lymphocytic Infiltrate of the Skin Be a Dermal Variant of Lupus Erythematosus? An Analysis of 210 Cases

et al. 2006

View full text Add to dashboard Cite

Background and Objective: The objective of this study was to evaluate the relationship between Jessner’s lymphocytic infiltration of the skin (JLI) and lupus erythematosus (LE), which has been the subject of debate since its initial description in 1953. Material and Methods: This is a retrospective study including all patients with a histopathologically ascertained diagnosis of JLI performed at the Laboratoire d’Histopathologie Cutanée of the Strasbourg University Hospital between 1993 and 2003. Information about patient characteristics and follow-up data were retrieved between 2004 and 2005. Special attention was paid to features indicative of LE. Results: 210 consecutive patients (102 women and 108 men) with a mean age 42 years were diagnosed with JLI in the reference period. 175 patients (83%) had multiple lesions and 32 patients (15%) had only a single lesion at the time of diagnosis (data not available in 3 patients). The head, neck and upper part of the thorax were involved in 171 patients (81%). An annular or arciform configuration and/or arrangement were present in 111 patients (53%). Lesions consisted of red (100%) papules or plaques (98%). Mean follow-up was 4 years. Sixteen patients (7.6%) had proven LE. Only 2 patients (1%) developed >4 ACR criteria of systemic LE. Furthermore, 1 patient had antiphospholipid antibody syndrome and 2 patients had rheumatoid arthritis. Conclusions: This high frequency of patients with typical features of LE strongly argues that JLI could be a dermal variant of LE and not an autonomous entity. It might be the cutaneous marker of a subset of LE patients with excellent prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Could Jessner’s Lymphocytic Infiltrate of the Skin Be a Dermal Variant of Lupus Erythematosus? An Analysis of 210 Cases

et al. 2006

View full text Add to dashboard Cite

show abstract

“…The clinical appearance of the erythematous papules on the face and upper trunk and the induction of the lesions by sun exposure resembles lupus erythematosus, especially the tumidus [7]and familial discoid forms [8], and polymorphic light eruption. In contrast to these entities, Jessner’s lymphocytic infiltration of the skin presents clinically with asymptomatic and nonscarring lesions and histologically with dermal infiltrates rather than with cytotoxic involvement of the epidermis such as interface dermatitis and hydropic degeneration [9]and interstitial mucin deposition [7]. However, it is difficult to differentiate Jessner’s lymphocytic infiltration from polymorphous light eruption and lupus erythematosus tumidus and some authors even proposed that the latter and Jessner’s lymphocytic infiltration are identical entities [10].…”

Section: Discussionmentioning

confidence: 99%

Familial Lymphocytic Infiltration of the Skin: Histochemical and Molecular Analysis in Three Brothers

Dippel

Poenitz²,

Klemke³

et al. 2002

Dermatology

View full text Add to dashboard Cite

Background: Lymphocytic infiltration of the skin (Jessner and Kanof) is a T cell pseudolymphoma characterized by the occurrence of recurrent asymptomatic papules and plaques and by a coat-sleeve-like perivascular lymphoid infiltrate. Rarely, familial cases have been reported. Objectives: Our study was performed to address the question of a genetic predisposition in a case of familial lymphocytic infiltration by histochemical and molecular analysis. Results: We report on 3 brothers with typical clinical and histological features of Jessner’s lymphocytic infiltration of the skin. Immunohistochemical analysis revealed a mixed lymphocytic infiltrate with a predominance of CD8+ T cells in all 3 patients. Molecular determination of T cell clonality by PCR-based GeneScan analysis of the T cell receptor (TCR)-γ-chain showed oligoclonal, pseudomonoclonal or polyclonal TCR-γ rearrangement patterns in lesional skin and in peripheral blood of all 3 brothers, while no common TCR idiotype was detected. Conclusion: Inherited deviations in TCR usage seem unlikely as a special cause of familial Jessner’s lymphocytic infiltration of the skin; lack of clonality furthermore supports the notion that this variant of the disease is as true a pseudo-T-cell lymphoma as are the spontaneous cases.

show abstract

“…Ever since Jessner and Kanof described for the first time a patient with lymphocytic infiltration of the skin in 1953 [1], there has been a continuing debate concerning the nosology of the disease, i.e. its classification as a unique disease entity or as a variant of cutaneous lupus erythematosus [7]or of polymorphous light eruption [8]. With the use of stringent inclusion/exclusion criteria, we have taken every measure possible to exclude patients with a clear-cut as well as a suspected diagnosis of the two latter diseases.…”

Section: Commentmentioning

confidence: 99%

“…whether it is a distinct entity [4]or a variant or special manifestation of lupus erythematosus, e.g. lupus erythematosus tumidus [7], or of the plaque type of polymorphous light eruption [8]. In addition, some authors have described JLIS localising solely on the trunk and have named it palpable migratory arciform erythema postulating that it might represent a unique disease entity [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Jessner’s Lymphocytic Infiltration of the Skin: A CD8+ Polyclonal Reactive Skin Condition

et al. 2003

View full text Add to dashboard Cite

Background: Jessner’s lymphocytic infiltration of the skin (JLIS) is a clinically and histologically distinct disease entity. Conflicting results have been reported concerning its differentiation from cutaneous lupus erythematosus and polymorphous light eruption, its relationship to palpable migratory arciform erythema and its classification as a B-cell or a CD4+ T-cell lymphoproliferative disease. Objective: Our study was performed in order to re-evaluate JLIS clinically and by immunohistochemical and molecular analyses. Methods: Stringent inclusion/exclusion criteria were used to collect a cohort of 34 patients with JLIS that did not overlap with lupus erythematosus or polymorphous light eruption. Clinical data were analysed, and immunohistochemical and molecular studies were performed including TCR-γ PCR GeneScan software analysis of tissue and peripheral blood samples. Results: In the majority of the patients, the lesions consisted only of papules and plaques while in 12% annular lesions were also seen. The lesions were found on the face (38%), on the trunk and arms (50%) or at both sites (12%). Immunohistochemical analyses revealed a clear predominance of T cells in all patients, and of CD8+ T cells in 77% of the patients. As judged by TCR-γ PCR GeneScan analysis, 98 and 79% of the tissue and peripheral blood samples, respectively, showed a polyclonal T-cell population; identical T-cell clones were not detected concomitantly in both the skin and the peripheral blood of the same patient. Conclusions: JLIS occurs at 2 major predilection sites, that is the face and trunk. Therefore introduction of palpable migratory arciform erythema as a separate entity is not justified. The lymphoid infiltrates are dominated immunohistochemically by CD8+ T cells that do not show clonality on molecular analysis. Thus, JLIS represents a characteristic CD8+ polyclonal reactive skin condition.

show abstract

Lupus Erythematosus Tumidus

Cited by 211 publications

References 49 publications

Could Jessner’s Lymphocytic Infiltrate of the Skin Be a Dermal Variant of Lupus Erythematosus? An Analysis of 210 Cases

Could Jessner’s Lymphocytic Infiltrate of the Skin Be a Dermal Variant of Lupus Erythematosus? An Analysis of 210 Cases

Familial Lymphocytic Infiltration of the Skin: Histochemical and Molecular Analysis in Three Brothers

Jessner’s Lymphocytic Infiltration of the Skin: A CD8+ Polyclonal Reactive Skin Condition

Contact Info

Product

Resources

About