Study on the susceptibility of Enterococcus faecalis from infectious processes to ciprofloxacin and vancomycin

Abstract

Enterococcus faecalis is considered a pathogen responsible for hospital infections and, due to its frequent multi-resistant profile, has caused preoccupations among many medical authorities. The objective of this study was to determine the antimicrobial susceptibility of 74 strains isolated from blood cultures and purulent secretions to vancomycin and ciprofloxacin through the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) by using the Microdilution test. The results showed a greater efficacy of vancomycin compared to ciprofloxacin (98.6% of the strains were inhibited by vancomycin at lower concentrations: 0.06 - 1 µg/ml). However, in the MBC analysis 73% of the strains showed a MBC of vancomycin only at high concentrations (equal to or higher than 64 µg/ml). For ciprofloxacin, the strains showed a broad sensitivity with MICs and MBCs distributed along all the MIC classes. Results also revealed a probability that some strains are tolerant to vancomycin, which indicates the need of other tests to confirm this characteristic

PEG–PLGA nanoparticles for encapsulating ciprofloxacin

“…The results were comparable with the antimicrobial susceptibility test of ciprofloxacin against E. faecalis in the previous report where the MIC 90 of ciprofloxacin ranged from 0.06 to 1 µg/ml 43 . However, 74 strains of E. faecalis presented high MBC 90% values (≥ 64 µg/ml) 44 , which were higher than the results obtained in this study. The differences might be due to many factors, such as bacterial strain, media, and using commercial drugs.…”

In vitro evaluation of local antibiotic delivery via fibrin hydrogel

“…The reasons might be due to the amount or strain of bacteria used for testing and the acidity of culture medium were difference. However, the bactericidal activity was favorably efficient compared to the resistant strains 25 …”