Study on the inflammatory response of PMMA/polystyrene/silica nanocomposite membranes for drug delivery and dental applications

Abstract

BackgroundThe application of polymeric materials in medical industry has grown drastically in the last two decades due to their various advantages compared to existing materials. The present research work emphases on the sol-gel technique to formulate the polymethyl methyl acrylate/polystyrene/silica composite membrane.MethodsThe characteristic of the composite was investigated through modern state art of instrumentation.ResultsThe functional groups attached to the polymer was absorbed by FTIR. The FTIR spectrum confirm that the blend was mixed thoroughly and the formation of unite intimately between the polymers. The membranes were observed by SEM for its surface homogeneity which depends upon the composition of the two blending polymers. The captured SEM images showed the formation of microcracks on the surface, which was evidently controlled by varying the constituent polymer ratios. The prepared blend membranes with 2:1 ratio of PMMA/PS/Si displayed higher water uptake compared to other blended membranes. The composite membranes had good hydroxyl apatite growth in SBF solution. Furthermore, the in vitro cytotoxicity studies carried out by MTT method, using RAW macrophage cells showed that all the samples exhibited excellent cell viability.ConclusionThe inflammatory response of composite with equal concentration of PMMA-PS were performed and observed no inflammation in comparison with control and other tested concentrations.

Facile Synthesis of Silver Hydroxyapatite (AgHAP) Reinforced Nanocomposites of Poly (styrene)‐Poly (methyl methacrylate) and Study of Their Mechanical and Blood‐Compatible Behavior

“…PMMA composite shows lower cell viability in the range of 94.6±2 in comparison to AgHAP loaded nanocomposites . It was found that the percentage viability of cells tend to be maximum and fall in the range of 149±3 (for 24 h) and 152±3 (for 48 h) for the nanocomposites having equal ratio of AgHAP:PS:PMMA (SET II, 1:1:1).…”

Sol-gel: Uncomplicated, routine and affordable synthesis procedure for utilization of composites in drug delivery: Review

“…Zhang et al [141] onto MCM-41 pore entrants to provide the silica-based nano-container following MSNs synthesis through the surfactant-assisted sol-gel system, with no surfactant removal. The release of the drug could be limited at pH 7.4 in the bloodstream based on the current in vitro results; nevertheless, due to the cancerous cell acidic microenvironment, an accelerated release would be found in cancerous tissues.…”

Bench-to-bedside: Feasibility of nano-engineered and drug-delivery biomaterials for bone-anchored implants and periodontal applications

“…Some studies demonstrated addition of different compounds/nanoparticles in membranes for bone regeneration with excellent biological and drug release results. However, it was unclear which sterilization process would be suitable for the new product and/or if the sterilization process could cause some damage to the biomaterials [ [10] , [11] , [12] ]. Moreover, the critical point of BDDS is drug maintenance until reaching the desired moment to apply it in preclinical models or clinical treatments.…”