Study on Anti-obesity and Hypoglycemic Effects of Lycium chinense Mill Extracts

황은영,; 홍정희,; 최준혁,; 이은정,; 이인선,

doi:10.3746/jkfn.2009.38.11.1528

Cited by 21 publications

(4 citation statements)

References 17 publications

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“…Type 2 diabetes is often caused by dysfunction of insulin secreted from the pancreas, reduced insulin sensitivity of liver and muscle tissues, or insulin resistance, any of which can raise the blood glucose level, resulting in persistent hyper-glycemia and dysfunction of pancreatic beta-cells due to glucotoxicity (2). Obesity, a leading cause of Type 2 diabetes, is closely related to insulin resistance not only due to an increase in plasma cholesterol, plasma lipids, and plasma free fatty acid levels, but also due to destruction of beta-cells related to lipotoxicity leading to poor secretion of insulin and dysfunction of beta-cells (3,4).…”

Section: Introductionmentioning

confidence: 99%

Effects of Allium hookeri root water extracts on inhibition of adipogenesis and GLUT-4 expression in 3T3-L1 adipocytes

Yang¹,

Choi²,

Jin³

et al. 2016

Food Sci Biotechnol

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Anti-adipogenic and antidiabetic activities of root water extracts (ARW) were assessed. Oil Red O staining showed that treatment with ARW caused a dose-dependent reduction in lipid accumulation. ARW was also involved in adipocyte lipolysis via LPL activity, and in the concentration of glycerol in a culture medium. On the basis of the concentration of adipokines following ARW treatment, ARW appeared to inhibit expression of PPAR-γ, to reduce concentrations of leptin and resistin, to increase the concentration of adiponectin, and to inhibit lipid accumulation. ARW modulated adipokine expression associated with insulin resistance and sensitivity. 3T3-L1 adipocytes treated with ARW showed increased GLUT-4 expression with increased glucose uptake into adipocytes. ARW showed effectiveness for improvement of diabetic conditions.

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Section: Introductionmentioning

confidence: 99%

Effects of Allium hookeri root water extracts on inhibition of adipogenesis and GLUT-4 expression in 3T3-L1 adipocytes

Yang¹,

Choi²,

Jin³

et al. 2016

Food Sci Biotechnol

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“…Administration of alloxan destroys β-cells in the islets of Langerhans, causing insulin deficiency and increasing blood glucose [ 26 ]. In addition, 70% ethanolic Lycium chinense Mill extracts (0.25, 0.5, 1, and 2 mg/mL) known to contain rutin, one of the components of NS, increased GLUT4 expression in 3T3-L1 cells and lowered blood glucose [ 45 ]. The citrus flavonoid, nobiletin (100 mg/kg, oral administration for 5 weeks), improved hyperglycemia and insulin resistance by increasing GLUT4 translocation in WAT and muscles of HFD-induced obese mice [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Obesity and Antidiabetic Effects of Nelumbinis Semen Powder in High-Fat Diet-Induced Obese C57BL/6 Mice

Hwang

Lee

2020

Nutrients

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Nelumbinis Semen (NS, the seeds of Nelumbo nucifera) extract is a traditional Korean medicine with anti-oxidant activity. The present study examined the anti-obesity and antidiabetic effects of NS powder in high-fat diet (HFD)-induced obese C57BL/6 mice. Mice (n = 8/group) were fed a normal diet (CON), HFD, HFD containing 5% NS powder (HFD-NS5%), or HFD containing 10% NS powder (HFD-NS10%) for 12 weeks. Food intake was relatively higher in groups HFD-NS5% and HFD-NS10%, while the food efficiency ratio was highest in group HFD (p < 0.05). HFD-NS5% reduced the body weight (−39.1%) and fat weight (−26.6%), including epididymal fat and perirenal fat, and lowered the serum triglyceride levels (−20.6%) compared with HFD. Groups HFD-NS5% and HFD-NS10% showed hepatoprotective properties, reducing the serum ALT levels (p < 0.05) and fat globules (size and number) in the liver compared with group HFD. HFD-NS5% and HFD-NS10% regulated the blood glucose, improved the glucose intolerance, and showed a 12.5% and 15.0% reduction in the area under the curve (AUC) of intraperitoneal glucose tolerance test (IPGTT), and a 26.8% and 47.3% improvement in homeostatic model assessment insulin resistance (HOMA-IR), respectively, compared with HFD (p < 0.05). Regarding the expressions of genes related to anti-obesity and antidiabetes, there was a 1.7- and 1.3-fold increase in PPAR-α protein expression, 1.4- and 1.6-fold increase in PPAR-γ protein expression, and 0.7- and 0.6-fold decrease in TNF-α protein expression, respectively, following HFD-NS5% and HFD-NS10% treatments, compared with HFD, and GLUT4 protein expression increased relative to CON (p < 0.05). These results comprehensively provide the fundamental data for NS powder’s functional and health-promoting benefits associated with anti-obesity and antidiabetes.

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“…비만은 상기한 濕, 痰, 瘀 같은 병리적 산물이 기부나 복막, 장부 등에 유체되는 것이다. 따라서, 補氣, 健脾, 祛濕利水, 消導, 化痰 작용을 갖 는 한약을 치료제로 사용하였으며, 실제 항비만 효과가 있는 한약재로 人蔘 28) , 黃連 29) , 苦瓜 30) , 枸杞子 31) , 側柏葉 32) , 木香 33) , 小茴香 34) 등이 연구된 바가 있다. .…”

Section: 고 찰unclassified

Anti-obesity effects of herbal extract YY312 in C57BL/6 mice fed a high-fat diet and 3T3-L1 cells

Kang¹,

Hwang²,

Choi³

et al. 2013

The Korea Journal of Herbology

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Objectives : The purpose of this study was to determine the anti-obesity effect and molecular mechanism of YY312, a herbal extract composed of Imperatae Rhizoma, Citri Unshius Pericarpium Immaturus, and Evodiae Fructus, on a high-fat diet-induced animal model and on 3T3-L1 cells. Methods : C57BL/6 mice were fed for 6 weeks with a normal diet or a high-fat diet (HFD). Then they orally administered daily with 300 mg/kg YY312 for next 10 weeks. Body weight and food consumption were recorded weekly and daily, respectively. Tissue weights, serum lipid, and glucose levels were analyzed at the end of the study. Additionally, the effects of YY312 on adipocyte differentiation in 3T3-L1 cells were examined. After differentiating 3T3-L1 cells were treated with YY312, Oil-red O staining, RT-PCR, and Western blotting were performed for lipid accumulation, mRNA expression of adipogenesis gene, and AMP-activated protein kinase (AMPK) phosphorylation, respectively. Results : YY312-administered mice showed a significant reduction of body weights and abdominal adipose tissue weights. YY312 also reduced the serum levels of triglycerides and total cholesterol, compared with the HFD group. Treatment with YY312 inhibited lipid accumulation and blocked expression of adipogenic transcription factors and lipogenesis genes, including peroxisome proliferator-activated receptor γ, CCAT/enhancer binding protein α and fatty acid synthase. YY312 increased AMPK phosphorylation in 3T3-L1 adipocytes.Conclusions : This study showed that herbal extract YY312 has an anti-obesity effect in vitro and in vivo.Thus, YY312 could be developed as a supplement for reduction of body weight gain induced by an HFD.

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Study on Anti-obesity and Hypoglycemic Effects of Lycium chinense Mill Extracts

Cited by 21 publications

References 17 publications

Effects of Allium hookeri root water extracts on inhibition of adipogenesis and GLUT-4 expression in 3T3-L1 adipocytes

Effects of Allium hookeri root water extracts on inhibition of adipogenesis and GLUT-4 expression in 3T3-L1 adipocytes

Anti-Obesity and Antidiabetic Effects of Nelumbinis Semen Powder in High-Fat Diet-Induced Obese C57BL/6 Mice

Anti-obesity effects of herbal extract YY312 in C57BL/6 mice fed a high-fat diet and 3T3-L1 cells

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