Study of Toxicology Effects of Herbicide Paraquat on Heamatological Parameters of &amp;lt;i&amp;gt;Mesopotamichthys sharpeyi&amp;lt;/i&amp;gt;

Hashemi, Rahin Alsadat; Jaddi, Y; Sadeghi, Mohammad Ali; Ghiamati, Samane; Motazedi, Msuod

doi:10.4236/ojms.2017.72018

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…Moreover, it seems that the reduction in red blood cells has been seen as a key factor which could be responsible for productivity reduction. 28 ROS (reactive oxygen species) production is seen as the medium through which paraquat dichloride exhibits its toxicity. 24 The ROS productions have been seen to result to cell damages and inducing the cascades of signaling mechanism which conclusively lead to cellular differentiation, adaptation, proliferation, necrosis or apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…Farmers in the developing countries are seen to have convenient access to it. 28 When humans encounter accidental or suicidal ingestion of paraquat dichloride, it is usually confirmed to be one of the chemicals used for suicidal attempts, with a dosage of 4 mg kg-1 b.wt. It is wellknown to be toxic to humans and animals at high doses, especially in the lungs, liver, kidneys and hearts.…”

Section: Discussionmentioning

confidence: 99%

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Effects of paraquat dichloride on adult male wistar rat. an approach in the toxicity of body weights and hematological tissues

Edo¹

2022

JAPLR

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The main objective of the experiment is aimed to examine the impact of paraquat dichloride on the body weights of adult male Wistar rats as well as in their haematological tissues. The total number of male Wistar rats was 48 and was divided into 4 groups of 12 each. The 1st group (Test 1) served as control. The other three groups served as experimental groups in which the paraquat dichloride was administered. The experimental groups which are 2nd group (Test 2), 3rd group (Test 3) and 4th group (Test 4) received doses of paraquat dichloride of 10 mg/kg b.wt/per oral/day, 20 mg/kg b.wt/per oral/day and 40 mg/kg b.wt/per oral/day respectively. The experiment was carried out for a time duration of 42 days. The mean values of body weights, erythrocyte indices, total erythrocyte count (TEC), total leucocyte count (TLC) and Hb concentrations were significantly (P<0.05) decreased in Test 2, 3 and 4 rats, excluding packed cell volume (PCV), which in comparison to the control groups. Outcomes and observations from hematological parameters and bone marrow revealed the toxicity of paraquat dichloride to hematological tissues resulting in anemia and bone marrow hypoplasia which eventually leads to failure of the bone marrow and extensively hematopoietic system of adult male Wistar rats following long term exposure and high concentration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of paraquat dichloride on adult male wistar rat. an approach in the toxicity of body weights and hematological tissues

Edo¹

2022

JAPLR

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“…Thomas [8], also cited that exposure to paraquat can be confirmed through urinary dithionite test [8]. It was discovered from several studies that paraquat poisoning alters the levels of certain biochemical parameters [9,10]. Zhou et al [10] in their research highlighted the toxic impact of paraquat in both survivors and nonsurvivors where it led to significant alteration in the concentrations of some biochemical parameters [10].…”

Section: Nationalmentioning

confidence: 99%

Hepatocellular Recovery of Chronic Paraquat Induced Liver Toxicity in Vitamin E and C Treated Male Wistar Rats

Okolonkwo¹,

Ekwempu

Brisibe

et al. 2022

IJBcRR

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Paraquat is an organic compound also known as methyl viologen, a chemical herbicide or weed killer with highly toxic effect on ingestion or exposure. Vitamin E and C are powerful antioxidants that act as initial responder against oxygen reactive species called free radicals which attack and destroy the tissues. The aim of this study was to determine a short term therapeutic effect of vitamin E and C combination on liver enzymes parameters of paraquat induced liver toxicity in male albino rats. 200 male albino rats were used for the study. The 200 rats were divided into four main groups (A, B, C, D) consisting of 50 rats in each group. The Groups were further divided into two subgroups having 25 rats in each subgroup. “A” group was not induced with paraquat while “B”, ‘C” and “D” groups were induced with increasing dose of 0.02g, 0.04g and 0.06g of paraquat respectively. “A” group had two subgroups; “Ao” and “AVEC” which represented the sub-group not treated with Vit E and the subgroup treated with Vit E (500mg) respectively. This also applied to group “B”, “C” and “D” paraquat was administered every forth night followed by treatment with the vitamins for one month. Blood samples were collected and analysed for liver function (SGOT, SGPT, ALT And GGT). There was a significant increase in the level of the liver enzymes among the “Ao”, “Bo”, “Co” and “Do”, p-value<0.05 and also among the “AVEC”, “BVEC”, “CVEC” and “DVEC”, p-value<0.05. The result also showed that there were significant differences in intra-group comparison in all the liver enzyme parameters, p-value<0.05 while there was no significant difference among the AO and AVEC subgroups for all parameters. This study has shown that vitamin E and C combination has a therapeutic effect in male albino rats on one month of weekly treatment. Therefore, a weekly treatment with Vit E and C may treat liver disease toxicity associated with paraquat toxicity in rats.

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“…Exposure to concentrated paraquat solutions can result in skin irritation, nail shedding, cracking, delayed wound healing, and cut healing issues [11]. Additionally, paraquat poisoning leads to alterations in various biochemical parameters, as evidenced by studies highlighting significant changes in biochemical concentrations among both survivors and nonsurvivors of paraquat exposure [14,15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Ethanolic Leaf Extract of Piper guineense (Uziza) on the Kidneys of Paraquat-Induced Adult Male Wistar Rats

Adolphus,

Lilian,

Omo

et al. 2024

JOCAMR

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Background: Paraquat (PQ) is one of the most toxic environmental pollutants. Objectives: This study was conducted to determine the effect of an ethanolic leaf extract of piper guineense on the kidneys of paraquat-induced adult Wistar rats. Methods: In this study, rats were divided into six groups. The control group (group A) received distilled water, and 20mg/kg of Paraquat was induced in groups B, C, D, E, and F; group C received 200mg/kg, group E received 80mg/kg, and group F received 100mg/kg of ethanolic leaf extract of Piper guineense, respectively. The animals were treated for 28 consecutive days. After the urea and serum creatinine collection, kidney histopathology was investigated. Results: PQ increased relative organ weight, urea, and serum creatinine levels, but it significantly decreased body weight across groups B and D. In the groups treated with piper guineense, urea and creatinine decreased compared with the PQ group, and body weight levels increased. Severe intra-renal inflammation and haemorrhage, necrotic debris around the hemorrhagic area, was seen histopathologically. The effects were ameliorated in Groups E and F, which received variable doses of the ethanolic leaf extracts of P. guineense. Conclusion: The obtained findings revealed that P. guineense leaf extract, used as a preventive compound, was able to reduce kidney dysfunction and tissue damage caused by PQ toxicity in the kidney.

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Study of Toxicology Effects of Herbicide Paraquat on Heamatological Parameters of <i>Mesopotamichthys sharpeyi</i>

Cited by 10 publications

References 21 publications

Effects of paraquat dichloride on adult male wistar rat. an approach in the toxicity of body weights and hematological tissues

Effects of paraquat dichloride on adult male wistar rat. an approach in the toxicity of body weights and hematological tissues

Hepatocellular Recovery of Chronic Paraquat Induced Liver Toxicity in Vitamin E and C Treated Male Wistar Rats

Effect of Ethanolic Leaf Extract of Piper guineense (Uziza) on the Kidneys of Paraquat-Induced Adult Male Wistar Rats

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