Study of the structure of streptokinase conjugates with a hydrophilic vinylpyrrolidone copolymer

Taratina, T.M.; Potapenko, V.Ye.; Klenin, S.I.; Bartoshevich, S.P.; Волкова, Л. И.; Denisov, Ilia G.; Moskvichev, B. V.

doi:10.1016/0301-4622(90)80034-5

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…This NG-70 formulation has a relatively higher proportion of VP than do other formulations. Because VP is hydrophilic in nature, it causes nanogels to swell more in an aqueous environment [20, 21]. However, in the dry state, different nanogel formulations have similar particle diameters.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of decitabine-loaded nanogels in overcoming cancer drug resistance is mediated via sustained DNA methyltransferase 1 (DNMT1) depletion

Vijayaraghavalu

Labhasetwar

2013

Cancer Letters

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DNA Methyltransferase 1 (DNMT1) promotes DNA methylation to maintain cancer drug resistance. The epigenetic drug, decitabine (DAC) is a potent hypomethylating agent, but its effect is transient because of its instability. We tested the efficacy of DAC-loaded nanogels in doxorubicin-resistant breast cancer cells, DAC-resistant melanoma cells, and leukemia cells. DAC in nanogel sustained DNMT1 depletion, prolonged cell arrest in the G2/M cell-cycle phase, and significantly enhanced antiproliferative effect of DAC. The efficacy of DAC-loaded nanogels was more significant in resistant than sensitive cells. Our data suggest that effective delivery of DAC and prolonged DNMT1 depletion are critical to overcoming drug resistance.

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Section: Discussionmentioning

confidence: 99%

Efficacy of decitabine-loaded nanogels in overcoming cancer drug resistance is mediated via sustained DNA methyltransferase 1 (DNMT1) depletion

Vijayaraghavalu

Labhasetwar

2013

Cancer Letters

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Monoalkylitaconates–vinylpyrrolidone copolymers. 2. Reactivity ratios and viscometric behaviour in dilute solutions

Radić¹,

Opazo²,

Vildósola³

et al. 1993

Polymer International

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Copolymerization of mono‐n‐decyl and mono‐n‐decyl and mono‐n‐dodecyl itaconate with vinylpyrrolidone (MOI‐VP, MDI‐VP and MDoI‐VP) was carried out using AIBN as initiator. The monomer reactivity ratios were determined by the Fineman‐Ross and Kelen‐Tüdös methods. Values of r1 and r2 were found to be less than unity for MOI‐VP, MDI‐VP and MDoI‐VP, corresponding to random copolymers with some tendency to alternance. Copolymers of various compositions were studied in solution, and Mark‐Houwink‐Kuhn‐Sakurada relationships were established in ethanol for MOI‐VP and MDI‐VP copolymers, and in 1‐propanol for MDoI‐VP. The rigidity factors s̀ and the characteristic ratio C∞ were obtained from Kθ values determined by using the Stockmayer‐Fixman relation. In all the copolymers the introduction of vinylpyrrolidone units produces flexibility of the polymer chain relative to the poly(monoitaconate) homopolymers, and the solution properties of these copolymers can be described by assuming a random coil model instead of a rigid rod or wormlike model as in poly(monoitaconates).

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The role of short hydrogen bonds in mechanisms of enzymatic action

Golubev

Денисов

Gindin³

et al. 1994

Journal of Molecular Structure

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Study of the structure of streptokinase conjugates with a hydrophilic vinylpyrrolidone copolymer

Cited by 3 publications

References 8 publications

Efficacy of decitabine-loaded nanogels in overcoming cancer drug resistance is mediated via sustained DNA methyltransferase 1 (DNMT1) depletion

Efficacy of decitabine-loaded nanogels in overcoming cancer drug resistance is mediated via sustained DNA methyltransferase 1 (DNMT1) depletion

Monoalkylitaconates–vinylpyrrolidone copolymers. 2. Reactivity ratios and viscometric behaviour in dilute solutions

The role of short hydrogen bonds in mechanisms of enzymatic action

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