“…This level of drug loading was compared to that of previous studies, in which nanostructured lipid carriers were developed. Drug loading ranged from 6% to 7% w/w for decitabine-loaded nanogels 7 and was 8.54%±2.65% in lipid-based nanocarriers developed by Neupane et al 10 The size obtained in our formulation was less than that of previously developed formulations, ranging from 80 to 200 nm. 9,10,30,31 Paillard et al have demonstrated that the number of LNCs internalized into cells is inversely proportional to their size, 32 suggesting that the size obtained for the THP-T80-LNC formulation could favor internalization.…”