Study of the relative dose-response of BANG-3  polymer gel dosimeters in epithermal neutron irradiation

Uusi-Simola, Jouni; Savolainen, Sauli; Kangasmäki, Aki; Heikkinen, Sami; Perkiö, Jussi; Ramadan, Usama Abo; Seppälä, Tiina; Karila, Johanna; Serén, Tom; Kotiluoto, Petri; Sorvari, Pekka; Auterinen, Iiro

doi:10.1088/0031-9155/48/17/310

Cited by 30 publications

(15 citation statements)

References 27 publications

(26 reference statements)

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“…From this study, it is concluded that PAG provides a good simulation of radiation transport in the brain and is very similar to water. In a study of the relative dose–response of BANG-3 polymer gel dosimeters in epithermal neutron irradiation, a good correspondence was found between the measured dose distribution and the calculated dose distribution obtained with a two-dimensional discrete ordinate radiation transport code (DORT) (Uusi-Simola et al 2003). This demonstrates that for the BANG-3 polymer gel, there is no significant change in dose sensitivity due to differences in LET that may occur in this epithermal neutron beam.…”

Section: Applications Of Polymer Gel Dosimetrymentioning

confidence: 94%

Polymer gel dosimetry

et al. 2010

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Polymer gel dosimeters are fabricated from radiation sensitive chemicals which, upon irradiation, polymerize as a function of the absorbed radiation dose. These gel dosimeters, with the capacity to uniquely record the radiation dose distribution in three-dimensions (3D), have specific advantages when compared to one-dimensional dosimeters, such as ion chambers, and two-dimensional dosimeters, such as film. These advantages are particularly significant in dosimetry situations where steep dose gradients exist such as in intensity-modulated radiation therapy (IMRT) and stereotactic radiosurgery. Polymer gel dosimeters also have specific advantages for brachytherapy dosimetry. Potential dosimetry applications include those for low-energy x-rays, high-linear energy transfer (LET) and proton therapy, radionuclide and boron capture neutron therapy dosimetries. These 3D dosimeters are radiologically soft-tissue equivalent with properties that may be modified depending on the application. The 3D radiation dose distribution in polymer gel dosimeters may be imaged using magnetic resonance imaging (MRI), optical-computerized tomography (optical-CT), x-ray CT or ultrasound. The fundamental science underpinning polymer gel dosimetry is reviewed along with the various evaluation techniques. Clinical dosimetry applications of polymer gel dosimetry are also presented.

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Section: Applications Of Polymer Gel Dosimetrymentioning

confidence: 94%

Polymer gel dosimetry

et al. 2010

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“…A previous gel dosimetry study in epithermal neutron beam had been done with BANG‐3 polymer gel dosimeters (10) . The linear nature of the BANG‐3 response to total absorbed dose in epithermal neutron irradiation was verified, even though part of the dose is induced by high‐LET particles.…”

Section: Introductionmentioning

confidence: 85%

MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

Uusi-Simola

Heikkinen

Kotiluoto

et al. 2007

J Applied Clin Med Phys

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Radiation‐sensitive polymer gels are among the most promising three‐dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose–response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry.PACS numbers: 87.53.Qc, 87.53.Wz, 87.66.Ff

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“…The rapid dose falloff in the right edge of the phantom seen in both Figs. 4͑a͒ and 4͑b͒ indicates the effects of oxygen, 36,[41][42][43] which will be discussed later in this section, and the effects of the B1-field inhomogeneity near the edges of the head coil. 3,18,21,22 The erroneous dose buildup in the downstream side of the water-equivalent material seen in those figures stems from the susceptibility effects in MRI images.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity phantoms for visualization of 3D dose distributions by MRI‐based polymer gel dosimetry

et al. 2004

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Heterogeneity corrections in dose calculations are necessary for radiation therapy treatment plans. Dosimetric measurements of the heterogeneity effects are hampered if the detectors are large and their radiological characteristics are not equivalent to water. Gel dosimetry can solve these problems. Furthermore, it provides three-dimensional (3D) dose distributions. We used a cylindrical phantom filled with BANG-3 polymer gel to measure 3D dose distributions in heterogeneous media. The phantom has a cavity, in which water-equivalent or bone-like solid blocks can be inserted. The irradiated phantom was scanned with an magnetic resonance imaging (MRI) scanner. Dose distributions were obtained by calibrating the polymer gel for a relationship between the absorbed dose and the spin-spin relaxation rate of the magnetic resistance (MR) signal. To study dose distributions we had to analyze MR imaging artifacts. This was done in three ways: comparison of a measured dose distribution in a simulated homogeneous phantom with a reference dose distribution, comparison of a sagittally scanned image with a sagittal image reconstructed from axially scanned data, and coregistration of MR and computed-tomography images. We found that the MRI artifacts cause a geometrical distortion of less than 2 mm and less than 10% change in the dose around solid inserts. With these limitations in mind we could make some qualitative measurements. Particularly we observed clear differences between the measured dose distributions around an air-gap and around bone-like material for a 6 MV photon beam. In conclusion, the gel dosimetry has the potential to qualitatively characterize the dose distributions near heterogeneities in 3D.

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Study of the relative dose-response of BANG-3 polymer gel dosimeters in epithermal neutron irradiation

Cited by 30 publications

References 27 publications

Polymer gel dosimetry

Polymer gel dosimetry

MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

Heterogeneity phantoms for visualization of 3D dose distributions by MRI‐based polymer gel dosimetry

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