MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

Uusi-Simola, Jouni; Heikkinen, Sami; Kotiluoto, Petri; Serén, Tom; Seppälä, Tiina; Auterinen, Iiro; Savolainen, Sauli

doi:10.1120/jacmp.v8i2.2409

Cited by 18 publications

(7 citation statements)

References 27 publications

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“…This demonstrates that for the BANG-3 polymer gel, there is no significant change in dose sensitivity due to differences in LET that may occur in this epithermal neutron beam. A fair correspondence was also found between the gel measured and the Monte Carlo calculated dose distribution for a MAGIC-type polymer gel (Uusi-Simola et al 2007) (figure 27). …”

Section: Applications Of Polymer Gel Dosimetrymentioning

confidence: 59%

Polymer gel dosimetry

et al. 2010

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Polymer gel dosimeters are fabricated from radiation sensitive chemicals which, upon irradiation, polymerize as a function of the absorbed radiation dose. These gel dosimeters, with the capacity to uniquely record the radiation dose distribution in three-dimensions (3D), have specific advantages when compared to one-dimensional dosimeters, such as ion chambers, and two-dimensional dosimeters, such as film. These advantages are particularly significant in dosimetry situations where steep dose gradients exist such as in intensity-modulated radiation therapy (IMRT) and stereotactic radiosurgery. Polymer gel dosimeters also have specific advantages for brachytherapy dosimetry. Potential dosimetry applications include those for low-energy x-rays, high-linear energy transfer (LET) and proton therapy, radionuclide and boron capture neutron therapy dosimetries. These 3D dosimeters are radiologically soft-tissue equivalent with properties that may be modified depending on the application. The 3D radiation dose distribution in polymer gel dosimeters may be imaged using magnetic resonance imaging (MRI), optical-computerized tomography (optical-CT), x-ray CT or ultrasound. The fundamental science underpinning polymer gel dosimetry is reviewed along with the various evaluation techniques. Clinical dosimetry applications of polymer gel dosimetry are also presented.

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Section: Applications Of Polymer Gel Dosimetrymentioning

confidence: 59%

Polymer gel dosimetry

et al. 2010

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“…Table 1 shows the ingredients in the gel and the amount of each one in it 11 . After preparing the gel, half of the nanoparticle was added to it according to the desired concentration and it was put in contact with a magnet and thus, a homogeneous solution was prepared.…”

Section: Methodsmentioning

confidence: 99%

An investigation of the effect of gold nanoparticles with different concentrations on increasing absorbed dose: an empirical and simulation study

Hoseinnezhad

Mahdavi

et al. 2018

J Radiother Pract

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PurposeThe purpose of this study was to determine the dose enhancement factor (DEF) of gold nanoparticles in a dosimeter gel and construct percentage depth dose curves, using the Optical CT system and the Monte Carlo simulation model, to determine the effect of increasing the dose caused by increasing the concentration of gold nanoparticles at depths in the gel.Materials and methodsThe Magic-f Gel was made based on the relevant protocol in the physics lab. To determine the amount of the increase in the absorbed dose, the gold nanoparticles were added to the gel and irradiated. An increase in the dose after adding nanoparticles to the gel vials was estimated both with the Optical CT system and by the Monte Carlo simulation method.ResultsDose enhancement curves for doses of 2, 4 and 6 Gy were prepared for gel vials without adding nanoparticles, and nanoparticle gels at concentrations 0·17, 3 and 6 mM. Also, the DEF was estimated. For the 0·17 mM molar gel, the DEF for 2, 4 and 6 Gy was 0·7, 0·743 and 0·801, respectively. For the 3 mM gel, it was 1·98, 2·5 and 2·2, and for the 6 mM gel, it was 37·4, 4·24 and 4·71, respectively.ConclusionThe enhancement of the dose after adding gold nanoparticles was confirmed both by experimental data and by simulation data.

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“…Polymer gel dosimeters have been proposed to verify various photon delivery techniques, such as intensity-modulated radiation therapy (IMRT) [2], [3], RapidArc radiation therapy [4], stereotactic radiosurgery (SRS) [5], [6], and brachytherapy [7], [8]. In addition, the potential applications of polymer gels for the proton therapy [9], [10], boron-neutron capture therapy (BNCT) [11], [12], and targeted radionuclide therapy [13] are promising because of the tissue-equivalent characteristics regarding the effective atomic number, electron density, and stopping power ratio of gel to water. A dose conversion system for the irradiated gels should offer high accuracy and reliability for the demanding applications.…”

Section: Introductionmentioning

confidence: 99%

A Novel Method of Estimating Dose Responses for Polymer Gels Using Texture Analysis of Scanning Electron Microscopy Images

et al. 2013

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Polymer gels are regarded as a potential dosimeter for independent validation of absorbed doses in clinical radiotherapy. Several imaging modalities have been used to convert radiation-induced polymerization to absorbed doses from a macro-scale viewpoint. This study developed a novel dose conversion mechanism by texture analysis of scanning electron microscopy (SEM) images. The modified N-isopropyl-acrylamide (NIPAM) gels were prepared under normoxic conditions, and were administered radiation doses from 5 to 20 Gy. After freeze drying, the gel samples were sliced for SEM scanning with 50×, 500×, and 3500× magnifications. Four texture indices were calculated based on the gray level co-occurrence matrix (GLCM). The results showed that entropy and homogeneity were more suitable than contrast and energy as dose indices for higher linearity and sensitivity of the dose response curves. After parameter optimization, an R 2 value of 0.993 can be achieved for homogeneity using 500× magnified SEM images with 27 pixel offsets and no outlier exclusion. For dose verification, the percentage errors between the prescribed dose and the measured dose for 5, 10, 15, and 20 Gy were −7.60%, 5.80%, 2.53%, and −0.95%, respectively. We conclude that texture analysis can be applied to the SEM images of gel dosimeters to accurately convert micro-scale structural features to absorbed doses. The proposed method may extend the feasibility of applying gel dosimeters in the fields of diagnostic radiology and radiation protection.

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MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

Cited by 18 publications

References 27 publications

Polymer gel dosimetry

Polymer gel dosimetry

An investigation of the effect of gold nanoparticles with different concentrations on increasing absorbed dose: an empirical and simulation study

A Novel Method of Estimating Dose Responses for Polymer Gels Using Texture Analysis of Scanning Electron Microscopy Images

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