Study of the Particle Size Effect on the Magnetic Separation of Bovine Serum Albumin (BSA)

Reza, Raúl Terrazas; Perez, Carlos A.; Martı́nez, Ana; Baques, D. Bueno; García-Casillas, Perla E.

doi:10.1166/sl.2010.1297

Cited by 9 publications

(5 citation statements)

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“…Additionally, IONP-based magnetic separation applications involve strict requirements such as chemical composition, particle size and size distribution, stability of magnetic properties, morphology, adsorption properties and low toxicity, and so on. For instance, Reza et al found that the BSA protein adhesions for magnetite–silica, magnetite–aminosilane and magnetite–silica–aminosilane arrays were 12.5%, 79.5% and 145.75% higher than for pure magnetite, respectively [ 362 ]. Arsianti et al systematically investigated the effect of IONP–PEI–DNA arrangement on transfection efficiency by varying the vector component mixing order.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

et al. 2015

Science and Technology of Advanced Materials

1,290

791

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This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

et al. 2015

Science and Technology of Advanced Materials

1,290

791

View full text Add to dashboard Cite

show abstract

“…In addition, the high aspect ratios, adsorption properties, chemical composition, low toxicity, morphology, particle size and its distribution and stability of magnetic properties are utmost important in the application of MNP-based magnetic separation. Reza et al discovered that the adhesions of BSA proteins for MNP-SiO 2 , MNP-aminosilane and MNP-SiO 2 -aminosilane arrays were 12.5%, 79.5%, and 145.75% more than those for bare MNPs, respectively [175].…”

Section: Bioseparationmentioning

confidence: 99%

Magnetite (Fe3O4) Nanoparticles in Biomedical Application: From Synthesis to Surface Functionalisation

et al. 2020

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Nanotechnology has gained much attention for its potential application in medical science. Iron oxide nanoparticles have demonstrated a promising effect in various biomedical applications. In particular, magnetite (Fe3O4) nanoparticles are widely applied due to their biocompatibility, high magnetic susceptibility, chemical stability, innocuousness, high saturation magnetisation, and inexpensiveness. Magnetite (Fe3O4) exhibits superparamagnetism as its size shrinks in the single-domain region to around 20 nm, which is an essential property for use in biomedical applications. In this review, the application of magnetite nanoparticles (MNPs) in the biomedical field based on different synthesis approaches and various surface functionalisation materials was discussed. Firstly, a brief introduction on the MNP properties, such as physical, thermal, magnetic, and optical properties, is provided. Considering that the surface chemistry of MNPs plays an important role in the practical implementation of in vitro and in vivo applications, this review then focuses on several predominant synthesis methods and variations in the synthesis parameters of MNPs. The encapsulation of MNPs with organic and inorganic materials is also discussed. Finally, the most common in vivo and in vitro applications in the biomedical world are elucidated. This review aims to deliver concise information to new researchers in this field, guide them in selecting appropriate synthesis techniques for MNPs, and to enhance the surface chemistry of MNPs for their interests.

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“…CS and other materials have been employed as coatings to obtain improved colloidal stability and other interesting properties in the biomedical area. [13][14][15] It is well known that pH-dependent properties of CS influence its biomedical activity and potential applications of the nanocomposites. Furthermore, polymers, such as CS, have been shown to improve the action of anticancer drugs in nanocomposites formulations.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties of chitosan–magnetite nanocomposites obtained with different pH

González

Arriaga

García-Casillas

2021

Polymers and Polymer Composites

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The physicochemical properties of the nanoparticle surface determine the performance of nanocomposites in biomedical applications such as their biodistribution and pharmacokinetics. The physicochemical properties of chitosan, such as apparent charge density and solubility, are pH dependent. Similarly, Fe3O4 nanoparticles are susceptible to variations in their physicochemical properties due to changes in pH. In this work, we evaluated the physicochemical properties of chitosan–magnetite nanocomposites that were suspended at pH 7.0, 9.0, and 11.0 to determinate the effect on particle size, zeta potential, and mass percentage of the polymeric coating, in addition to the crystalline phase and magnetic properties of magnetite phase. X-ray diffraction results exposed that the present phase was magnetite with no other phases present and that the crystallite size was between 10.8 and 14.1 nm. Fourier transform infrared verified the chitosan functional groups in treated samples while the percentage of mass determined by TGA found to be nearly 9%. Scanning electron microscopy micrographs corroborated the spherical shape of the bare and chitosan-coated nanoparticles. Dynamic light scattering results showed that chitosan coating modifies the zeta potential, going from a potential of −11.8 mV for bare particles to −3.0 mV (pH 11). Besides, vibrating sample magnetometer measurements showed that coercivity remained very low, which is desirable in biomedical applications.

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Study of the Particle Size Effect on the Magnetic Separation of Bovine Serum Albumin (BSA)

Cited by 9 publications

References 0 publications

Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

Magnetite (Fe3O4) Nanoparticles in Biomedical Application: From Synthesis to Surface Functionalisation

Physicochemical properties of chitosan–magnetite nanocomposites obtained with different pH

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