Physicochemical properties of chitosan–magnetite nanocomposites obtained with different pH

González, Christian Chapa; Arriaga, Javier Ulises Navarro; García-Casillas, Perla E.

doi:10.1177/09673911211038461

Cited by 9 publications

(6 citation statements)

References 34 publications

(45 reference statements)

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“…where D is the average particle size (nm), K is a shape factor constant equal to 0.94, [30] λ is the wavelength of X-ray wavelength, β is full-width at half maximum (FWHM) of the peak in radians, and θ is the Bragg diffraction angle of the XRD peak in degree. The degree of crystallinity (X c ) before and after modification of Cu-MOF was further calculated by performing the deconvolution of the Xray diffractograms using a Gaussian-Lorentzian function and the areas corresponding to amorphous (A am ) and the crystalline (A cr ) content was fitted to equation 2.…”

Section: Materials Characterizationsmentioning

confidence: 99%

Synergistic Antifungal Activity of Dialdehyde Chitosan Loaded with Copper Metal‐Organic Framework (Cu‐MOF)

Kiprono Kirui,

Shigwenya Madivoli,

Mwanza Nzilu

et al. 2024

ChemistrySelect

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Fungal resistance and the environmental degradation posed by conventional fungicides necessitate the need to develop new antifungal agents that can inhibit fungal growth. This study sought to prepare biofungicides by leveraging on the antifungal activity of copper‐metal organic framework (Cu‐MOF) and dialdehyde chitosan (Cs) isolated from black soldier flies (BSF). Cs were oxidized using potassium periodate to obtain dialdehyde Cs (OCs) and thereafter, Cu‐MOF was loaded resulting in Cu‐MOF‐OCs. Fourier Transform Infrared spectrophotometer (FT‐IR) and powder X‐ray diffraction (XRD) confirmed the presence of carbonyl functional groups in OCs and sharp intense peaks associated with Cu that interacted. The changes in surface morphology and the presence of Cu in the MOFs as obtained with Scanning Electron Microscope‐ Energy Dispersive X‐ray (SEM‐EDX), indicated the successful loading of Cu‐MOF on the oxidized Cs. Thermogravimetric analysis (TGA) showed a loss of approximately 31.51 % of the loaded OCs and 40.72 % framework around ∼200 to ∼300 °C and ∼410 to ∼475 °C respectively. The antifungal activity of OCs, Cu‐MOF, and Cu‐MOF‐OCs against Aspergillus brasiliensis and Candida albicans was performed using the plate count method and the results suggested that MOF modulated the antifungal activity exerted by the OCs.

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Section: Materials Characterizationsmentioning

confidence: 99%

Synergistic Antifungal Activity of Dialdehyde Chitosan Loaded with Copper Metal‐Organic Framework (Cu‐MOF)

Kiprono Kirui,

Shigwenya Madivoli,

Mwanza Nzilu

et al. 2024

ChemistrySelect

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“…They are very abundant in nature, low cost, and easily modifiable [ 78 ]. Chitosan is derived from chitin, which is the main structure component of mollusks, insects, and fungi, and is widely used for the coverage of MNPs [ 79 , 80 ]. Chitosan is a natural polysaccharide that plays an important role in cross-linking with target molecules due to both the hydroxyl and amine groups in its structure.…”

Section: Mnp Synthesis Surface Coating and Functionalizationmentioning

confidence: 99%

Magnetite-Based Biosensors and Molecular Logic Gates: From Magnetite Synthesis to Application

et al. 2023

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In the last few decades, point-of-care (POC) sensors have become increasingly important in the detection of various targets for the early diagnostics and treatment of diseases. Diverse nanomaterials are used as building blocks for the development of smart biosensors and magnetite nanoparticles (MNPs) are among them. The intrinsic properties of MNPs, such as their large surface area, chemical stability, ease of functionalization, high saturation magnetization, and more, mean they have great potential for use in biosensors. Moreover, the unique characteristics of MNPs, such as their response to external magnetic fields, allow them to be easily manipulated (concentrated and redispersed) in fluidic media. As they are functionalized with biomolecules, MNPs bear high sensitivity and selectivity towards the detection of target biomolecules, which means they are advantageous in biosensor development and lead to a more sensitive, rapid, and accurate identification and quantification of target analytes. Due to the abovementioned properties of functionalized MNPs and their unique magnetic characteristics, they could be employed in the creation of new POC devices, molecular logic gates, and new biomolecular-based biocomputing interfaces, which would build on new ideas and principles. The current review outlines the synthesis, surface coverage, and functionalization of MNPs, as well as recent advancements in magnetite-based biosensors for POC diagnostics and some perspectives in molecular logic, and it also contains some of our own results regarding the topic, which include synthetic MNPs, their application for sample preparation, and the design of fluorescent-based molecular logic gates.

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“…[23][24][25][26] Amino silane is a commonly used coating for nanoparticles due to its biocompatibility and ability to improve the stability of the particles in biological environments. [26][27][28][29][30] In the literature, various modifications have been proposed for magnetite or cobalt ferrite magnetic nanoparticles, including the use of other materials such as silica, [31] chitosan, [32] or polyethylene glycol (PEG), [33] to improve their properties for biomedical applications. These modifications have shown promising results in terms of increased stability, biocompatibility, and reduced toxicity of the nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…The addition of coatings to nanoparticles can also significantly alter their properties, enabling them to be more biocompatible or to better interact with their surroundings. [ 16,17 ] The interface between cells and nanoparticles is of critical importance for understanding the behavior and potential applications of nanomaterials in biomedicine. The surface properties of nanoparticles play a key role in determining their interaction with cells, including their uptake, toxicity, and ability to trigger cellular responses.…”

Section: Introductionmentioning

confidence: 99%

“…In the literature, various modifications have been proposed for magnetite or cobalt ferrite magnetic nanoparticles, including the use of other materials such as silica, [ 31 ] chitosan, [ 32 ] or polyethylene glycol (PEG), [ 33 ] to improve their properties for biomedical applications. These modifications have shown promising results in terms of increased stability, biocompatibility, and reduced toxicity of the nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

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Enhancing the Cytocompatibility of Cobalt‐Iron Ferrite Nanoparticles Through Chemical Substitution and Surface Modification

Flores Urquizo,

Máynez Tozcano,

Valencia Gómez

et al. 2023

Adv Materials Inter

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Due to their potential in numerous interdisciplinary fields, such as drug delivery, hyperthermia, and magnetic resonance imaging, magnetic nanoparticles have attracted widespread attention. In this study, cobalt ferrite nanoparticles are synthesized with varying amounts of iron and cobalt ions, and their cytocompatibility is evaluated before and after surface modification with amino-silane (AEPTMS). Characterization of the synthesized nanoparticles is performed using scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. In addition, it is observed that a slight reduction in the saturation magnetization of the coated materials. The cytotoxicity of these materials is evaluated using the MTT assay on fibroblast cells. This study focuses on the importance of the interface between the surface of magnetic nanoparticles, their coating, and their interaction with cells. This study presents an innovative approach to enhancing the cytocompatibility of cobalt ferrite nanoparticles through chemical substitution and surface modification with AEPTMS. The key findings demonstrate that the iron and cobalt ion ratio significantly impacts cytotoxicity, with the AEPTMS coating found to increase cell viability. These findings demonstrate the potential of these materials for biomedical applications, highlighting the importance of both the composition and surface coating of magnetic nanoparticles for biomedical applications.

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Physicochemical properties of chitosan–magnetite nanocomposites obtained with different pH

Cited by 9 publications

References 34 publications

Synergistic Antifungal Activity of Dialdehyde Chitosan Loaded with Copper Metal‐Organic Framework (Cu‐MOF)

Synergistic Antifungal Activity of Dialdehyde Chitosan Loaded with Copper Metal‐Organic Framework (Cu‐MOF)

Magnetite-Based Biosensors and Molecular Logic Gates: From Magnetite Synthesis to Application

Enhancing the Cytocompatibility of Cobalt‐Iron Ferrite Nanoparticles Through Chemical Substitution and Surface Modification

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