Study of the immunologic response of marine-derived collagen and gelatin extracts for tissue engineering applications

Alves, Ana L.; Costa-Gouveia, Joana; Castro, Joana Vieira de; Sotelo, Carmen G.; Vázquez, José Antonio; Pérez‐Martín, Ricardo I.; Torrado, Egídio; Neves, Nuno M.; Reis, Rui L.; Silva, Tiago H.

doi:10.1016/j.actbio.2022.01.009

Cited by 31 publications

(14 citation statements)

References 80 publications

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“…The wide application of marine biomaterials also includes the treatment of osteoarthritis, diabetes [188] and diabetic foot ulcers [189], anti-inflammatory materials [190], and some applications in organ tissue engineering such as liver regeneration [191], intestinal replacement [192,193], tendon regeneration [194], and myocardial regeneration [195], etc. Kyojin Kang et al fabricated alginate hydrogel and mouse-induced hepatocyte-like cells (miHeps) dispersed in hydrogel and generated a 3D hepatic scaffold via 3D bioprinting [191].…”

Section: Other Biomedical Applicationsmentioning

confidence: 99%

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Zhang

Liang

et al. 2022

Marine Drugs

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Oceans have vast potential to develop high-value bioactive substances and biomaterials. In the past decades, many biomaterials have come from marine organisms, but due to the wide variety of organisms living in the oceans, the great diversity of marine-derived materials remains explored. The marine biomaterials that have been found and studied have excellent biological activity, unique chemical structure, good biocompatibility, low toxicity, and suitable degradation, and can be used as attractive tissue material engineering and regenerative medicine applications. In this review, we give an overview of the extraction and processing methods and chemical and biological characteristics of common marine polysaccharides and proteins. This review also briefly explains their important applications in anticancer, antiviral, drug delivery, tissue engineering, and other fields.

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Section: Other Biomedical Applicationsmentioning

confidence: 99%

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Zhang

Liang

et al. 2022

Marine Drugs

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“…Less immunogenic with low inducing pro-inflammatory cytokines as well as inducible NO synthase [ 79 ]…”

Section: Figurementioning

confidence: 99%

Collagen-Based Biomaterials in Periodontal Regeneration: Current Applications and Future Perspectives of Plant-Based Collagen

et al. 2022

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Collagen is the most widely distributed protein in human body. Within the field of tissue engineering and regenerative medical applications, collagen-based biomaterials have been extensively growing over the past decades. The focus of this review is mainly on periodontal regeneration. Currently, multiple innovations of collagen-based biomaterials have evolved, from hemostatic collagen sponges to bone/tissue regenerative scaffolds and injectable collagen matrices for gene or cell regenerative therapy. Collagen sources also differ from animal to marine and plant-extracted recombinant human type I collagen (rhCOL1). Animal-derived collagen has a number of substantiated concerns such as pathogenic contamination and transmission and immunogenicity, and rhCOL1 is a potential solution to those aforementioned issues. This review presents a brief overview of periodontal regeneration. Also, current applications of collagen-based biomaterials and their mechanisms for periodontal regeneration are provided. Finally, special attention is paid to mechanical, chemical, and biological properties of rhCOL1 in pre-clinical and clinical studies, and its future perspectives in periodontal regeneration are discussed.

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“…For this reason, it is a polymer that can be dissolved in water and processed to acquire different configurations, whether as hydrogels, fibers, films, scaffolds, etc. ( Figure 5 ) [ 67 , 68 , 69 ].…”

Section: Gelatinmentioning

confidence: 99%

Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review

Barreto

Medeiros

Shearer

et al. 2022

JFB

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Nano-/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new tissue formation, activate cell proliferation, stimulate the genetic expression of proteins, and trigger unique anti-bacterial, anti-inflammatory, and anti-cancer functionalities. Recently, composites based on biopolymers and BG particles have been developed with various state-of-the-art techniques for tissue engineering. Gelatin, a semi-synthetic biopolymer, has attracted the attention of researchers because it is derived from the most abundant protein in the body, viz., collagen. It is a polymer that can be dissolved in water and processed to acquire different configurations, such as hydrogels, fibers, films, and scaffolds. Searching “bioactive glass gelatin” in the tile on Scopus renders 80 highly relevant articles published in the last ~10 years, which signifies the importance of such composites. First, this review addresses the basic concepts of soft and hard tissue engineering, including the healing mechanisms and limitations ahead. Then, current knowledge on gelatin/BG composites including composition, processing and properties is summarized and discussed both for soft and hard tissue applications. This review explores physical, chemical and mechanical features and ion-release effects of such composites concerning osteogenic and angiogenic responses in vivo and in vitro. Additionally, recent developments of BG/gelatin composites using 3D/4D printing for tissue engineering are presented. Finally, the perspectives and current challenges in developing desirable composites for the regeneration of different tissues are outlined.

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Study of the immunologic response of marine-derived collagen and gelatin extracts for tissue engineering applications

Cited by 31 publications

References 80 publications

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Collagen-Based Biomaterials in Periodontal Regeneration: Current Applications and Future Perspectives of Plant-Based Collagen

Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review

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