Collagen-Based Biomaterials in Periodontal Regeneration: Current Applications and Future Perspectives of Plant-Based Collagen

Abstract

Collagen is the most widely distributed protein in human body. Within the field of tissue engineering and regenerative medical applications, collagen-based biomaterials have been extensively growing over the past decades. The focus of this review is mainly on periodontal regeneration. Currently, multiple innovations of collagen-based biomaterials have evolved, from hemostatic collagen sponges to bone/tissue regenerative scaffolds and injectable collagen matrices for gene or cell regenerative therapy. Collagen sources also differ from animal to marine and plant-extracted recombinant human type I collagen (rhCOL1). Animal-derived collagen has a number of substantiated concerns such as pathogenic contamination and transmission and immunogenicity, and rhCOL1 is a potential solution to those aforementioned issues. This review presents a brief overview of periodontal regeneration. Also, current applications of collagen-based biomaterials and their mechanisms for periodontal regeneration are provided. Finally, special attention is paid to mechanical, chemical, and biological properties of rhCOL1 in pre-clinical and clinical studies, and its future perspectives in periodontal regeneration are discussed.

Collagen Derived from Fish Industry Waste: Progresses and Challenges

“…This was done by using a unique method based on fish collagen. It was discovered that the mechanical and physical forces of fish-scale-derived collagen were adequate for this purpose [ 153 , 154 ]. Collagen was also demonstrated to play a critical role in tooth tissue repair.…”

Self-Assembled Peptide Nanostructures for ECM Biomimicry

“…It is thus not surprising that they are very popular components in the development of new solutions as biomaterials for applications in medicine [1][2][3][4], cosmetics [5,6] and food science [7], including highly biotechnological products, such as cultured meat [8]. Collagen [9,10], gelatin [11][12][13][14], keratin [15][16][17], and silk fibroin [18,19] are amongst the most widely used proteins to develop biomaterials.…”

The Effect of Argon Plasma Surface Treatment on Poly(lactic-co-glycolic acid)/Collagen-Based Biomaterials for Bone Tissue Engineering

“…Collagen is a natural polymer derived from animal tissues. Its remarkable cell affinity and low rejection in vivo has made it a desirable material in biomedical research studies [ 5 ], and it is commonly used in bone grafting and as a scaffold material for tissue engineering and cell-based gene therapies [ 6 ]. The desirability of collagen in bone tissue engineering is due to its abundance, biocompatibility, and low risk of triggering an immune response [ 7 ].…”

“…In particular, type I collagen is known for its capability and potential for osteogenic differentiation [ 9 ]. Furthermore, collagen is known to be a hemostatic material for wound dressing applications and can promote healing and regeneration [ 6 ].…”