Study of the Extraction of LSD from Illicit Blotters for HPLC Determination

Veress, Tibor

doi:10.1520/jfs13514j

Cited by 23 publications

(14 citation statements)

References 7 publications

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“…The amount of LSD determined in the analyzed samples was consistent with the values found in literature, lying within the range described by the literature which reports a wide variation of LSD in blotters (30 to 500 µg) analyzed by different authors (Veress, 1993;United Nations, 1989;Clarkson et al, 1998).…”

Section: Resultssupporting

confidence: 90%

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Quantification of LSD in illicit samples by high performance liquid chromatography

Marinho

Leite

2010

Braz. J. Pharm. Sci.

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In the present study, a method using high performance liquid chromatography to quantify LSD, in blotter papers seized in Minas Gerais, was optimized and validated. Linearity, precision, recovery, limits of detection and quantification, and selectivity were the parameters used to evaluate performance. The samples were extracted with methanol:water (1: 1) in an ultra-sound bath. The linearity between 0.05 and 20.00 µg/mL (0.5 and 200.0µg of LSD/blotter) was observed with satisfactory mean intra and inter assay precision (RSD r = 4.4% and RSD R = 6.4%, respectively) and with mean recoveries of 83.4% and 84.9% to the levels of 1.00 and 20.00 µg/mL (10 and 200µg LSD/blotter). The limits of detection and quantification were 0.01 and 0.05 µg/mL, respectively (0.1 and 0.5 µg of LSD/blotter). The samples of blotters (n =22) were analyzed and the mean value of 67.55 µg of LSD/blotter (RSD=27.5%) was found. Thus, the method used showed satisfactory analytical performance, and proved suitable as an analytical tool for LSD determination in illicit samples seized by police forces. No presente trabalho, um método utilizando cromatografia líquida de alta eficiência foi otimizado e validado para quantificar o LSD em selos apreendidos em Minas Gerais. A linearidade, precisão, recuperação, limites de detecção e quantificação e seletividade foram os parâmetros de desempenho avaliados. As amostras foram extraídas com metanol: água (1:1) em banho de ultra-som. A linearidade entre 0,05 a 20,00 mg/mL (0,5 a 200 µg LSD/blotter) foi observada com precisão média, intra e inter ensaio, satisfatória (RSD r = 4,4% e RSD R = 6,4%, respectivamente) e com recuperações médias de 83,4% e 84,9% para os níveis de LSD de 1,00 e 20,00 mg/mL (10 e 200 µg LSD/selo). Os limites de detecção e quantificação encontrados foram de 0,01 e 0,05 mg/mL, respectivamente (0,1 e 0,5 µg LSD/selo). As amostras de selos (n = 22) foram analisadas e o valor médio encontrado foi de 67,55 µg de LSD/selo (RSD% = 27,5). Desta forma, o método analítico apresentou desempenho satisfatório, capaz de ser utilizado como instrumento de análise para a determinação do LSD em amostras ilícitas apreendidas pelas forças policiais.Unitermos: LSD/detecção. Química Forense. Toxicologia analítica. Validação intralaboratorial. Cromatografia líquida de alta efeciência/análise quantitativa.

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Section: Resultssupporting

confidence: 90%

“…Methanol:water (1:1) was selected as the LSD solvent extractor according to the study by Veress (Veress, 1993). Blotters are usually impregnated with LSD in salt form (for example, LSD tartrate) so a high polarity solvent is more efficient to extract the drug.…”

Section: Resultsmentioning

confidence: 99%

Quantification of LSD in illicit samples by high performance liquid chromatography

Marinho

Leite

2010

Braz. J. Pharm. Sci.

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show abstract

“…1,2 If the sample blotter paper size and its amount of LSD were 8 mm×8 mm and 500 mg, the piece of blotter paper (1.4 mm×0.8 mm) contained about 8.8 µg. Since some parts of the extracted LSD were used for measurement, the real identification limit was less than 8.8 µg.…”

Section: Calculation Of Identification Limitmentioning

confidence: 99%

“…Generally, the content of LSD in a square sheet (its dimensions about 8 mm×8 mm) will vary from 2 to 40 µg 1 and 30 to 500 µg. 2 Veress reported an extraction of LSD from illicit blotters and determination of LSD by high-performance liquid chromatography (HPLC). 2 On-line high-performance TLC coupling with a Fourier transform infrared spectrometer (FT-IR) was used for identification of LSD in paper after solvent extraction by Pfeifer and Kovar.…”

mentioning

confidence: 99%

“…2 Veress reported an extraction of LSD from illicit blotters and determination of LSD by high-performance liquid chromatography (HPLC). 2 On-line high-performance TLC coupling with a Fourier transform infrared spectrometer (FT-IR) was used for identification of LSD in paper after solvent extraction by Pfeifer and Kovar. 3 Harris and Kane 4 reported a method of identification of LSD using a microscope-sampling device with FT-IR.…”

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