Study of the diclofenac/phospholipid interactions with liposomes and monolayers

Effect of emulsifier type against the action of bile salts at oil–water interfaces

“…The correlation between theory and experiment is satisfactory (given by the parameter ε in Table 2) within the range of applicability of the model, which excludes the interfacial saturation interval (Fainerman et al, 2002). It is important to note that the values of the molecular area (ω) for NaTDC, Pluronic and Epikuron shown in Table 2 are in agreement with values reported in literature (Guay & Bisaillon, 1983;Small, 1971;Souza, Oliveira, Scarpa, & Oliveira, 2004;Van der Meeren, Vanderdeelen, & Baert, 1989). In fact, the interfacial area of NaTDC given in Table 2 agrees with the area reported in a very recent work for NaDC at the air-water interface (He et al, 2011).…”

Caffeine Encapsulated in Small Unilamellar Liposomes: Characerization and In Vitro Release Profile

“…[1] The interactions of drugs with organized structures, such as liposomes, are of considerable importance because of the effects of these systems on drug solubility and chemical reactivity, [2][3][4][5][6] drug absorption and targeting, [7][8][9] and the enhancement of therapeutic effects and reduction of toxicity. [10][11][12] Liposomes are roundish vesicles consisting of one or several lipid bilayers separated by a water phase. The most commonly used lipids for liposome preparation are phospholipids, in particular, phosphatidylcholine-also known as lecithin-and phosphatidylethanolamine.…”

Interactions of amphotericin B derivative of low toxicity with biological membrane components—the Langmuir monolayer approach

“…The use of the Langmuir method allows for a precise and continuous control of such parameters as molecular packing, physical state, lateral pressure, composition and quality of the surface. In particular, mixed monolayers composed of constituents of biological membranes, such as phospholipids, sterols and glycolipids, provide a highly informative approach for studying intermolecular interactions between membrane components, usually phospholipids, and biomolecules, for example, various drugs [2][3][4][5], hormones [6,7], enzymes [8][9][10][11], proteins [12][13][14][15][16][17][18][19][20][21], etc. Such investigations may be of much help in elucidating a mode of action of many physiological active compounds [22][23][24][25][26][27][28][29].…”

“…The first one, appropriate for biomolecules that are water soluble, is based on spreading of a monolayer from phospholipids/sterols and its subsequent compression on the top of aqueous subphase containing the dissolved biomolecule (see, for example, [2,3]). Alternatively, a solution with the biomolecule is injected into bulk water after the monolayer has been spread and compressed to a particular surface pressure value (see, for example, [32]).…”