Study of the Concentration of Thyroxin and Cortisol in Cows With Fat Hepatosis in the Transit Period

Vasileva, S.V.; Karpenko, L.Yu.

doi:10.17238/issn2072-6023.2019.3.202

Cited by 3 publications

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“…1 , Галецкий В.Б. 2 , Рудяк В.П. 3 ( 1 ФГБОУ ВО «Санкт-Петербургский государственный университет ветеринарной медицины», 2 АО «Гатчинский ККЗ, 3 ООО " Лигногумат" )…”

Section: Study Of Thyroid Status In Newly Calved Cows With Disorder O...unclassified

“…Известно, что у коровы после отёла обменные процессы резко меняются в сторону усиления лактогенеза [2,6]. В связи с тем, что в ранний новотельный период организм коровы чрезвычайно чувствителен к любым нарушениям технологии кормления и содержания, отзываясь на это развитием различных метаболических нарушений, весьма интересным представляется изучить тиреоидный статус у коров после отёла в связи с гепатопатией.…”

Section: Introductionunclassified

“…Как известно, билирубин -один из наиболее показательных маркеров нарушения функции печени. У коров в транзитный период печень подвержена чрезмерной липидной нагрузке, поэтому нередко развивается гепатоз, зачастую усугубляющийся влиянием разнообразных токсинов [1,2,7].…”

Section: Introductionunclassified

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Study of thyroid status in newly calved cows with disorder of liver functio

Vasileva¹,

Kozitcyna²

2021

jour

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The article presents the results of a study of thyroid hormones - total triiodothyronine, total and free thyroxine in fresh cows at different ranges of bilirubin concentration in the blood. It was found that with an increase in the level of bilirubin, the functional activity of the thyroid gland decreases according to the principle of inverse relationship. It was found that the most sensitive marker to an increase in bilirubin is total T4. With a mild and moderate degree of hyperbilirubinemia, the level of this hormone decreases by 36.7-39.2%, with a pronounced increase in bilirubin in the blood, thyroxine decreases 3.6 times. With a slight increase in bilirubin in the blood, the level of T3 and fT4 decreases by 4.4-5.6%. With a more pronounced dysfunction of the liver, the degree of decrease in these hormones is much greater and is reliable. So, the concentration of T3 in groups decreases by 20.5-23.0%, and fT4 - by 33.4-40.0%. A decrease in the content of thyroid hormones in the blood against the background of hepatopathy is explained by a slowdown in all metabolic processes due to a decrease in the functional activity of the liver. The reason for the hypofunction of the thyroid gland is the lack of the need for the amount of hormones that is produced in the body of a healthy animal. Against the background of hepatopathy, the homeostasis of triiodothyronine, as the most important metabolically active thyroid hormone, is maximally maintained. At the same time, a decrease in the rate of catabolism of hormones in the liver does not contribute to a change in their concentration in the blood, since the half-life of T4 is much higher than T3, therefore it is the decrease in the rate of their synthesis in the gland and secretion into the blood that matters.

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Section: Study Of Thyroid Status In Newly Calved Cows With Disorder O...unclassified

Section: Introductionunclassified

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Study of thyroid status in newly calved cows with disorder of liver functio

Vasileva¹,

Kozitcyna²

2021

jour

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Concentration of kisspeptin, testosterone and cortisol in the blood of cows during the transit period with energy metabolism disorders

Shiryaev,

Larkina,

Nikitin

et al. 2024

Agrarnaâ nauka

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In the clinically healthy cows of the Holstein breed (n = 20), a hormonal background was studied during theperiod of deepness and after the edema. For this purpose, the concentration of kisspeptin, testosterone and cortisol was determined in serum cows in the blood cows. The animals conducted regular observation with the conduct of clinical and obstetric and gynecological studies. Depending on the concentration of glucose and beta-hydroxybutyric acid on the 5th day after calving, the cows were divided into two groups. The first group included 15 heads with a glucose concentration greater than 3 mmol/l and a beta-hydroxybutyric acid level below 1 mmol/l. In the second group, 5 heads had violations in energy exchange (glucose levels less than 3 mmol/l, beta-hydroxybutyric acid above 1 mmol/l). On the 15th day after the hotel, normalization of energy homeostasis was recorded. The concentration of kisspeptin in the preventive period in both groups decreased to the hotel. At the same time, the concentration of kisspeptin in the blood of animals in the group with energy exchange disorders was 2.4–3 times higher on the 9th, 7th and 5th days before calving (p < 0.01–0.05) compared with the first group. In production experience, the concentration of all three hormones after the hotel decreased with significant intergroup differences. The level of kisspeptin was reliably higher in the preventive period in the experimental group and on the 5th day after the hotel (p < 0.05). The cortisole level was held at a high level of up to 7 days after the hotel (p < 0.05). The concentration of testosterone in the blood throughout the transit period was reliably high in the animals of the experimental group.

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Calculation of reference intervals for indicators of thyroid hormones and cortisol in horses

Vasileva,

Karpenko

2024

jour

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The article discusses the results of calculating reference intervals for thyroid hor mones and cortisol in adult horses. The study included the results of a laboratory study of the concentrations of total triiodothyronine, total and free thyroxine and cortisol from 50 horses aged 3 to 29 years, including 17 mares, 13 stallions and 20 geldings. All animals underwent an extensive biochemical blood test, the results of which revealed no pathological changes.To calculate the normative limits of fluctuations for each hormone, calculations were carried out using the Tukey method, which is used to determine the reference limits in the case of a small number of variants in the group and the absence of a normal distribution. Microsoft Excel was used for calculations. The conducted studies made it possible to clarify the reference intervals for thyroid hormones and cortisol in horses, which were: total triiodothyronine (T3) - 1.13-4.04 nmol/l, total thyroxine (T4) - 20.97-57.42 nmol/l, free thyroxine (fT4) 7.38-23.07 pmol/l, cortisol – 39.42-227.02 nmol/l. The results obtained can be recommended for use not only for the clinical and biochemical laboratory of St. Petersburg State University of Medicine, but also for all veterinary laboratories using diagnostic test systems for enzyme immunoassay of Vital Development Corporation.

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Study of the Concentration of Thyroxin and Cortisol in Cows With Fat Hepatosis in the Transit Period

Cited by 3 publications

References 0 publications

Study of thyroid status in newly calved cows with disorder of liver functio

Study of thyroid status in newly calved cows with disorder of liver functio

Concentration of kisspeptin, testosterone and cortisol in the blood of cows during the transit period with energy metabolism disorders

Calculation of reference intervals for indicators of thyroid hormones and cortisol in horses

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